CURRICULUM VITAE
Whayoung Lee MD
Whayoung Lee MD
Assistant Professor
Department of Pathology
Division of Administration
Department of Pathology
Division of Administration
OFFICE ADDRESS: |
Froedtert/MCW Laboratory Building |
9200 W Wisconsin Ave |
Milwaukee, WI 53226 |
EDUCATION: |
03/2002 - 02/2008 MD, Ewha Womans University School of Medicine, Seoul, Korea |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
03/2008 - 02/2009 Intern, Samsung Medical Center, Seoul, Korea |
07/2017 - 06/2021 Resident, Department of Anatomical Pathology and Laboratory Medicine, University of California Irvine Medical Center, Orange, CA |
07/2019 - 09/2020 Served as a Chief resident |
07/2021 - 06/2022 Fellow physician/Clinical Instructor, Gastrointestinal and Hepatic/pancreatobiliary pathology fellowship, University of California Irvine Medical Center, Orange, CA |
FACULTY APPOINTMENTS: |
08/2022 - Present Assistant Professor, Department of Pathology and Laboratory Medicine, The Medical College of Wisconsin, Milwaukee, WI |
HOSPITAL STAFF PRIVILEGES: |
08/2022 - Present Froedtert Memorial Lutheran Hospital, 9200 W. Wisconsin Ave., Milwaukee, WI 53226 |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
American Board of Pathology AP/CP board | 06/2021 | None |
Certificates | Issued By | Issue Date | Expiration |
Lean Six Sigma Yellow | Belt | 10/2020 | None |
ECFMG | 12/2010 | None | |
Licensure | Number | Issue Date | Expiration |
California License | A164493 | 08/2019 | None |
Wisconsin License | 8101 | 08/2022 | |
Korean medical License | 9597 | 02/2008 | |
AWARDS AND HONORS: |
01/2013 - Present Ocular Tissue Engineering and Regenerative Ophthalmology Research Program (OTERO) Fellowship program |
11/2013 - Present TTS-IXA 2013 Young Investigator Award |
11/2015 - Present TTS-IXA 2015 Young Investigator Award |
03/2019 - Present KOPANA (Korean Pathologists Association of North America) Trainee Award |
06/2021 - Present Edward R. Aquilla Award for Excellence in Research Award |
03/2022 - Present KOPANA (Korean Pathologists Association of North America) Trainee Award |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2008 - Present Korean Medical Association |
2012 - 2016 International Xenotransplantation Association |
2012 - 2016 The Transplantation Society |
2017 - Present Korean Pathologists Association of North America (KOPANA) |
2017 - Present American Society for Clinical Pathology (ASCP) |
2017 - Present College of American Pathologists (CAP) |
2018 - Present United States and Canadian Academy of Pathology (USCAP) |
2022 - Present Pancreatobiliary Pathology Society (PBPS) |
2022 - Present Hans Popper Hepatopathology Society |
INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Bioprosthetic heart valve replacement: Another form of xenotransplantation, 2015 International Xenotransplantation Association congress Cambridge, Melbourne, Australia, 11/2015 - Present |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
Local |
1. Lee W et al., Glutaraldehyde fixation of porcine bioprosthetic heart valves may be detrimental to long-term function. Surgical Research Day, University of Pittsburgh, 11/2014 - Present |
2. Lee W et al., In vitro studies on tissues and cells from GTKO/hCD46/NeuGcKO pigs. Starzl Transplantation Institute Retreat, University of Pittsburgh, 11/2015 - Present |
National |
1. Lee W et al., Cultured porcine corneal endothelial sheets on a decellularized porcine matrix as an alternative to deceased human corneas for transplantation. Biennial Cornea Conference, 05/2013 - Present |
2. Lee W et al., The Efficacy of MRI-guided Prostate Biopsies - Review of Experience in Four Years from a Single Institution. 2019 KOPANA Seminar, 03/2019 - Present |
4. Lee W et al., Primary Pancreatic Gastrointestinal Stromal Tumor: A Rare Case Report and Review of the Literature. 2019 CAP19 meeting, 09/2019 - Present |
3. Lee W et al., Collision Tumor of Uterus: A Report of Two Rare Phenomenons and Brief Review of Literature. 2019 CAP19 meeting, 09/2019 - Present |
6. Zada S et al., Sleeve Gastrectomy: Preoperative Endoscopic Biopsy and Specimen Sampling - A 10 Year Comprehensive review. 2022 CAP22 meeting, 10/2022 - Present |
5. Cohen G et al., Rash - The Initial Presentation of Angioimmunoblastic T-cell Lymphoma - A Real Head Scratcher. 2021 American College of Physicians (ACP) Virtual meeting, June 2021 (Poster presentation) |
International |
1. Lee W et al., In vitro and in vivo testing of an anti-CD40mAb clone, 2C10, in xenotransplantation. International Xenotransplantation Association congress, 11/2013 - Present |
2. Miyagawa Y et al., N-glycolylneuraminic acid is strongly expressed in the pig cornea: relevance to corneal xenotransplantation. International Xenotransplantation Association congress, 11/2013 - Present |
3. Hara H et al., Density, morphology, and in vitro proliferative capacity of porcine corneal endothelial cells (CECs); relevance to clinical corneal xenotransplantation. International Xenotransplantation Association congress, 11/2013 - Present |
4. Lee W et al., A comparison of three methods of decellularization of porcine corneas to reduce immunogenicity following anterior lamellar keratoplasty. International Xenotransplantation Association congress, 11/2013 - Present |
5. Lee W et al., Effect of a Rho/Rho kinase inhibitor, Y-27632, on inflammation in cultured porcine corneal endothelial cells: relevance to corneal xenotransplantation. International Xenotransplantation Association congress, 11/2013 - Present |
6. Lee W et al., The potential significance of NeuGc in the structural valve deterioration of bioprosthetic heart valves. International Xenotransplantation Association congress, 11/2015 - Present |
7. Lee W et al., Investigation of the potential clinical significance of the expression of NeuGc on pig aortas and corneas. International Xenotransplantation Association congress, 11/2015 - Present |
8. Lee W et al., The Efficacy of MRI-guided Prostate Biopsies - Review of Experience in Four Years from a Single Institution. 2019 USCAP meeting, 03/2019 - Present |
10. Lee W et al., S100-red Staining Enhances Sensitivity of Perineural Invasion Detection in Orbital Squamous Cell Carcinoma. 2020 USCAP meeting, 03/2020 - Present |
9. Law T et. al., Validation of a New Method to Evaluate Mitotic Activity in Core Biopsies with Invasive Breast Carcinoma. 2020 USCAP meeting, 03/2020 - Present |
12. Lee W et al., Cross Sectional Approach of Processing Rectal Cancer Resections Detects Closer Circumferential Margin than the Regular Approach. 2021 USCAP meeting, 03/2021 - Present |
11. Lee W et al., For HER2 Detection in Metastatic Colorectal Adenocarcinoma: IHC, FISH or Both? 2021 USCAP meeting, 03/2021 - Present |
15. Sherehan Zada et al., Clinicopathological Features of Intestinal and Foveolar Gastric Adenomas. 2022 USCAP meeting, 03/2022 - Present |
14. Xiaodong Li et al., Evaluation of Tumor Budding and Poorly Differentiated Clusters as Independent Predictors of Clinical Outcome in Ampulla of Vater Carcinoma. 2022 USCAP meeting, 03/2022 - Present |
13. Kapitolina Semenova et al., Pathology Review and Cost Benefit Analysis of Ileostomy/Colostomy Specimens: A 20-year Experience. 2022 USCAP meeting, 03/2022 - Present |
16. Lee W et al., Low Grade Appendiceal Mucinous Neoplasm (LAMN): The M Stage is a Significant Predictive Factor for Disease Recurrence, Irrespective of the T Stage. 2022 USCAP meeting, 03/2022 - Present |
MEDICAL COLLEGE TEACHING ACTIVITIES: |
Resident and Fellow Education |
02/2021 - Present Lymphoma of the gastrointestinal tract |
10/2021 - Present Inflammatory bowel disease |
01/2022 - Present Pathology of Small and Large bowel |
05/2022 - Present Pathology of Pancreatic tumor |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Lee SE, Mehra R, Fujita M, Roh DS, Long C, Lee W, Funderburgh JL, Ayares DL, Cooper DK, Hara H. Characterization of porcine corneal endothelium for xenotransplantation. Semin Ophthalmol. 2014 May;29(3):127-35. PMID: 23758340. |
2. Cohen D, Miyagawa Y, Mehra R, Lee W, Isse K, Long C, Ayares DL, Cooper DK, Hara H. Distribution of non-gal antigens in pig cornea: relevance to corneal xenotransplantation. Cornea. 2014 Apr;33(4):390-7. PMID: 24488129. |
3. Lee W, Miyagawa Y, Long C, Cooper DK, Hara H. A comparison of three methods of decellularization of pig corneas to reduce immunogenicity. Int J Ophthalmol. 2014 Aug 18;7(4):587-93. PMID: 25161926. |
4. Lee W, Hara H, Cooper DK, Manji RA. Expression of NeuGc on pig heart valves. Xenotransplantation. 2015 Mar-Apr;22(2):153-4. PMID: 25753748. |
5. Manji RA, Lee W, Cooper DKC. Xenograft bioprosthetic heart valves: Past, present and future. Int J Surg. 2015 Nov;23(Pt B):280-284. PMID: 26190838. |
6. Lee W, Miyagawa Y, Long C, Zhang M, Cooper DK, Hara H. Effect of Rho-kinase Inhibitor, Y27632, on Porcine Corneal Endothelial Cell Culture, Inflammation and Immune Regulation. Ocul Immunol Inflamm. 2016 Oct;24(5):579-93. PMID: 26471144. |
7. Lee W, Satyananda V, Iwase H, Tanaka T, Miyagawa Y, Long C, Ayares D, Cooper DK, Hara H. In vitro testing of an anti-CDd40 monoclonal antibody, clone 2C10, in primates and pigs. Transpl immunol. 2015 Nov;33(3):185-91. PMID: 26458513. |
8. Lee W, Miyagawa Y, Long C, Ekser B, Walters E, Ramsoondar J, Ayares D, Tector AJ, Cooper DK, Hara H. Expression of NeuGc on pig cornea and its potential significance in pig corneal xenotransplanation. Cornea. 2016 Jan;35(1):105-13. PMID: 26418433. |
9. Tanaka T, Fujita M, Bottino R, Piganelli JD, McGrath K, Li J, Lee W, Iwase H, Wijkstrom M, Bertera S, Long C, Landsittel D, Haruma K, Cooper DK, Hara H. Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs. Islets. 2016;8(1):1-12. PMID: 26857703. |
10. Lee W, Hara H, Ezzelarab MB, Iwase H, Bottino R, Long C, Ramsoondar J, Ayares D, Cooper DK. Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs. Xenotransplantation. 2016 Mar;23(2):137-50. PMID: 26988899. |
11. Cooper DK, Ezzelarab MB, Hara H, Iwase H, Lee W, Wijkstrom M, Bottino R. The pathobiology of pig-to-primate xenotransplantation: a historical review. Xenotransplantation. 2016 Mar;23(2):83-105. PMID: 26813438. |
12. Lee W, Long C, Ramsoondar J, Ayares D, Cooper DK, Manji RA, Hara H. Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration? Xenotransplantation. 2016 Sep;23(5):370-80. PMID: 27511593. |
13. Lee W, Mammen A, Dhaliwal DK, Long C, Miyagawa Y, Ayares D, Cooper DK, Hara H. Development of retrocorneal membrane following pig-to-monkey penetrating keratoplasty. Xenotransplantation. 2017 Jan;24(1):10.1111/xen.12276. PMID: 28247507. |
14. Iwase H, Liu H, Schmelzer E, Ezzelarab M, Wijkstrom M, Hara H, Lee W, Singh J, Long C, Lagasse E, Gerlach JC, Cooper DKC, Gridelli B. Transplantation of hepatocytes from genetically engineered pigs into baboons. Xenotransplantation. 2017 Mar;24(2):10.1111/xen.12289. PMID: 28130881. |
15. Gao B, Long C, Lee W, Zhang Z, Gao X, Landsittel D, Ezzelarab M, Ayares D, Huang Y, Cooper DKC, Wang Y, Hara H. Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. PLoS One. 2017 Jul 17;12(7):e0180768. PMID: 28715486. |
16. Li T, Lee W, Hara H, Long C, Ezzelarab M, Ayares D, Huang H, Wang Y, Esmon CT, Cooper DKC, Iwase H. An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation. Transplantation. 2017 Oct;101(10):2330-2339 PMID: 28157735. |
17. Stahl EC, Bonvillain RW, Skillen CD, Burger BL, Hara H, Lee W, Trygg CB, Didier PJ, Grasperge BF, Pashos NC, Bunnell BA, Bianchi J, Ayares DL, Guthrie KI, Brown BN, Petersen TH. Evaluation of the host immune response to decellularized lung scaffolds derived from α-Gal knockout pigs in a non-human primate model. Biomaterials. 2018 Dec;187:93-104. PMID: 30312852. |
18. Li Q, Shaikh S, Iwase H, Long C, Lee W, Zhang Z, Wang Y, Ayares D, Cooper DKC, Hara H. Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: Relevance to studies of xenotransplantation. Xenotransplantation. 2019 May;26(3):e12498. PMID: 30770572. |
19. Guo W, Lee W, Lu Y, Li X, Chandan VS. Incidence and significance of GATA3 positivity in gallbladder adenocarcinoma. Hum Pathol. 2020 Dec;106:39-44. PMID: 32991930. |
20. Lee W, Li X, Lee S, Chandan VS. Primary pancreatic gastrointestinal stromal tumor. Hepatobiliary Pancreat Dis Int. 2021 Aug;20(4):391-393. PMID: 32878724. |
21. Lee W, Li X, Chandan VS. Hepatocellular carcinomas can be Special AT-rich sequence-binding protein 2 positive: an important diagnostic pitfall. Hum Pathol. 2020 Nov;105:47-52. PMID: 32946879. |
22. Lee W, Chandan VS, Johnson C, Li X. Atypical Cells in Peritoneal Cleft: A Pitfall in Diagnosis of Colorectal Adenocarcinoma. Int J Surg Pathol. 2021 Aug;29(5):506-509. PMID: 33455512. |
23. Farzaneh T, Nowroozizadeh B, Han M, Lee W. Diagnostic Utility of LEF1 Immunostain in Cytology Specimens of Solid Pseudopapillary Neoplasm of Pancreas. Acta Cytol. 2021;65(3):250-256. PMID: 33887729. |
24. Guo W, Farzaneh T, Lee W, Nael A, Li X, Chandan VS. A limited panel of INSM1 and LEF1 immunostains accurately distinguishes between pancreatic neuroendocrine tumor and solid pseudopapillary neoplasm. Pathol Res Pract. 2021 Jul;223:153462. PMID: 34048981. |
25. Lee W, HaDuong J, Sassoon A, Dao T, Nael A. A Liver Transplant for Local Control in a Pediatric Patient with Metastatic TFE3-Associated Perivascular Epithelioid Cell Tumor (PEComa) to the Liver. Case Rep Pathol. 2021 Oct 5;2021:3924565. PMID: 34650822. |
26. Lebby E, Hanna M, Bui TL, Rudd A, Lee W, Houshyar R. Pneumatosis cystoides intestinalis in a trauma patient presenting with pneumoperitoneum: a case report. J Med Case Rep. 2021 Dec 17;15(1):597. PMID: 34915922. |
27. Lee W, Law T, Lu Y, Lee TK, Ibarra JA. Mitotic counts in one high power field in breast core biopsies is equivalent to counts in 10 high power fields. Pathology. 2022 Feb;54(1):43-48. PMID: 34916071. |
28. Lee W, Chandan VS. Gallbladder carcinomas: Review and updates on morphology, immunohistochemistry and staging. Hum Pathol. 2022 Jun 23:S0046-8177(22)00158-7. doi: 10.1016/j.humpath.2022.06.013. Epub ahead of print. PMID: 35753408. |
29. Dayyani F, Lee W, Houshyar R, Fontaine P. Rapid and Deep Response to Lorlatinib in Pancreatic High Grade Neuroendocrine Carcinoma with a Treatment Emergent Novel KANK1-ALK Fusion. JCO Precision Oncology. 2022 (accepted). |
Books, Chapters, and Reviews |
1. Cooper, David KC, et al. "The Pathobiology of Pig-to-Primate Xeno.: A Historical Review." Clinical Xenotransplantation. Springer, Cham, 2020. 27-63. |
2. Lee W and Quintero-Rivera F. Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma). The Compendium of Cancer Genome Aberrations (CCGA) |