Medical College of Wisconsin
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Ziqing Liu PhD
Assistant Professor
Department of Physiology

Basic Science Building
8701 Watertown Plank Rd
Milwaukee, WI 53226

09/01/2004 - 07/01/2008 BS, University of Science and Technology of China, Hefei, China
08/08/2008 - 02/28/2014 PhD, Indiana University School of Medicine, Indianapolis, IN

03/15/2014 - 09/16/2022 Postdoc/Research Associate, Pathology & Lab Medicine; iBGS, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

10/01/2022 - Present Assistant Professor, Physiology, Medical College of Wisconsin, 8701 W Watertown Plank Rd, WAUWATOSA, WI 53226

01/01/2019 - Present American Heart Association
07/01/2022 - Present North America Vascular Biology Organization (Education Committee member)

Refereed Journal Publications/Original Papers
1. Liu Z*, Wang L*, Welch JD*, Ma H, Zhou Y, Vaseghi HR, Yu S, Wall JB, Alimohamadi S, Zheng M, Yin CY, Shen WN, Prins JF, Liu JD, Qian L (2017). Single Cell Transcriptomics Reconstructs Lineage Conversion from Fibroblast to Cardiomyocyte. Nature 551, 100-104 *co-first author.
2. Zhou Y*, Liu Z*, Welch JD, Gao X, Wang L, Garbutt T, Keepers B, Ma H, Prins JF, Shen WN, Liu JD, Qian L (2019). Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming. Cell Stem Cell 25 (1), 149-164. *co-first author.
3. Wang L*, Liu Z*, Yin C, Asfour H, Chen O, Li Y, Bursac N, Liu J, Qian L (2014). Stoichiometry of Gata4, Mef2c, and Tbx5 Influences the Efficiency and Quality of Induced Cardiac Myocyte Reprogramming. Circulation Research 116 (2), 237-244. *co-first author. Editorial’s pick of the issue. Editorial: Muraoka N, Ieda M. Stoichiometry of Transcription Factors Is Critical for Cardiac Reprogramming. Circulation Research.
4. Liu Z, Ruter DL, Quigley KM, Tanke N, Jiang Y, Bautch VL (2021). Single-Cell RNA Sequencing Reveals Endothelial Cell Transcriptome Heterogeneity under Homeostatic Laminar Flow. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Aug 26:ATVBAHA121316797. Featured article of the issue.
5. Ruter DL, Liu Z, Ngo KM, X S, Marvin A, Buglak DB, Kidder EJ, Bautch VL (2021). SMAD6 Integrates Endothelial Cell Homeostatic Flow Responses Downstream of Notch. Angiogenesis. 2021 May;24(2):387-398.
6. Ma H*, Liu Z*, Yang Y*, Feng D, Dong Y, Garbutt T, Hu Z, Wang L, Luan H, Cooper C, Li Y, Welch J, Qian L, Liu J (2021). Functional Coordination of Non-myocytes Plays a Key Role in Adult Zebrafish Heart Regeneration. EMBO Reports. 2021 e52901 *co-first author.
7. Wang L, Ma H, Huang P, Xie Y, Near D, Wang H, Xu J, Yang Y, Xu Y, Garbutt T, Zhou Y, Liu Z, Yin C, Bressan M, Taylor JM, Liu JD Qian L (2020). Downregulation of Beclin1 Promotes Direct Cardiac Reprogramming. Sci Transl Med 12(566): eaay7856.
8. Ma H, Yu S, Liu X, Zhang Y, Fakadej T, Liu Z, Yin CY, Shen WN, Locasale JW, Taylor JM, Qian L, Liu JD (2019). Lin28a Regulates Pathological Cardiac Hypertrophic Growth through Pck2-Mediated Enhancement of Anabolic Synthesis. Circulation 139 (14), 1725-1740.
9. Zhou Y, Alimohamadi S, Wang L, Liu Z, Wall JB, Yin C, Liu J, Qian L (2018). A Loss of Function Screen of Epigenetic Modifiers and Splicing Factors during Early Stage of Cardiac Reprogramming. Stem Cells International.
10. Zhou Y, Wang L, Liu Z, Alimohamadi S, Yin CY, Liu JD, Qian L (2017). Comparative Gene Expression Analyses Reveal Distinct Molecular Signature between Induced Cardiomyocytes and Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Reports 20 (13), 3014-3024.
11. Liu Z, Chen O, Wall JB, Zheng M, Zhou Y, Wang L, Vaseghi HR, Qian L, Liu JD (2017). Systematic Comparison of 2A Peptides for Cloning Multi-Genes in a Polycistronic Vector. Scientific Reports 7: 2193.
12. Liu Z, Chen O, Zheng M, Wang L, Zhou Y, Yin CY, Liu JD, Qian L (2016). Re-Patterning of H3k27me3, H3k4me3 and DNA Methylation during Fibroblast Conversion into Induced Cardiomyocytes. Stem Cell Research 16 (2), 507–518.
13. Zhou Y, Wang L, Vaseghi HR, Liu Z, Lu R, Alimohamadi S, Yin CY, Fu JD, Wang GG, Liu JD, Qian L (2016). Bmi1 Functions as a Critical Epigenetic Modulator during Early Phase of Direct Cardiac Reprogramming. Cell Stem Cell 18 (3), 382-95. Commentary: Herrer D and Benard A. Bmi1-Mediated Epigenetic Signature Acts as a Critical Barrier for Direct Reprogramming to Mature Cardiomyocytes. Stem Cell Investigation.
14. Wang L, Liu Z, Yin C, Zhou Y, Liu J, Qian L (2015). Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5. JoVE (Journal of Visualized Experiments) e53426-e53426.
15. Liu Z, F Zhao, He JJ (2014). Hepatitis C Virus (HCV) Interaction with Astrocytes: Non-Productive Infection and Induction of IL-18. Journal of Neurovirology 20 (3), 278-293
16. Liu Z, X Zhang, Q Yu, He JJ (2014). Exosome-Associated Hepatitis C Virus in Cell Cultures and Patient Plasma. Biochemical and biophysical research communications 455 (3), 218-222
17. Liu Z, He JJ (2013). Cell-Cell Contact-Mediated Hepatitis C Virus (HCV) Transfer, Productive Infection and Replication and Its Requirement for HCV Receptors. Journal of Virology 87 (15), 8545-58.
18. Park IW, Ndjomou J, Wen Y, Liu Z, Ridgway ND, Kao CC, He JJ (2013). Inhibition of HCV Replication by Oxysterol-Binding Protein-Related Protein 4 (ORP4) through Interaction with HCV NS5B and Alteration of Lipid Droplet Formation. Plos One 8 (9), e75648.
19. Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, Liu Z, Qin X, He JJ, Yu Q (2012). CD59 Incorporation Protects Hepatitis C Virus against Complement-Mediated Destruction. Hepatology 55 (2), 354-63.
20. J Zhan, B Ding, R Ma, X Ma, X Su, Y Zhao, Z Liu, J Wu, H Liu (2010). Develop Reusable and Combinable Designs for Transcriptional Logic Gates. Molecular Systems Biology 6 (1), 388.