Medical College of Wisconsin
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Anthony J. Trimboli PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biochemistry
Program: Program Development

Publications (31)

  • Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner. (Wu J, Liu X, Reeser JAW, Trimboli AJ, Pécot T, Sizemore GM, Naidu SK, Fernandez SA, Yu L, Hallett M, Park M, Leone GW, Hildreth BE, Ostrowski MC) Mol Cancer Res 2022 Aug 05;20(8):1233-1246 PMID: 35533313 PMCID: PMC9357052 SCOPUS ID: 2-s2.0-85135596986 05/10/2022       4 Citations
  • Stromal Platelet-Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain. (Thies KA, Hammer AM, Hildreth BE 3rd, Steck SA, Spehar JM, Kladney RD, Geisler JA, Das M, Russell LO, Bey JF 4th, Bolyard CM, Pilarski R, Trimboli AJ, Cuitiño MC, Koivisto CS, Stover DG, Schoenfield L, Otero J, Godbout JP, Chakravarti A, Ringel MD, Ramaswamy B, Li Z, Kaur B, Leone G, Ostrowski MC, Sizemore ST, Sizemore GM) Cancer Res 2021 Feb 01;81(3):606-618 PMID: 32327406 PMCID: PMC7581545 SCOPUS ID: 2-s2.0-85100405678 04/25/2020       27 Citations
  • Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer. (Basree MM, Shinde N, Koivisto C, Cuitino M, Kladney R, Zhang J, Stephens J, Palettas M, Zhang A, Kim HK, Acero-Bedoya S, Trimboli A, Stover DG, Ludwig T, Ganju R, Weng D, Shields P, Freudenheim J, Leone GW, Sizemore GM, Majumder S, Ramaswamy B) Breast Cancer Res 2019 Jul 17;21(1):80 PMID: 31315645 PMCID: PMC6637535 SCOPUS ID: 2-s2.0-85070057466 07/19/2019       29 Citations
  • Stromal PTEN determines mammary epithelial response to radiotherapy. (Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC) Nat Commun 2018 Jul 17;9(1):2783 PMID: 30018330 PMCID: PMC6050339 SCOPUS ID: 2-s2.0-85050372792 07/19/2018       18 Citations
  • Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. (Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC) Oncogene 2017 Nov 23;36(47):6658 PMID: 29035387 SCOPUS ID: 2-s2.0-85034961349 10/17/2017       3 Citations
  • Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1. (Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC) Oncogene 2017 Apr 20;36(16):2297-2308 PMID: 27797378 PMCID: PMC5398932 SCOPUS ID: 2-s2.0-84992697172 11/01/2016       19 Citations
  • Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps. (Sáenz Robles MT, Chong JL, Koivisto C, Trimboli A, Liu H, Leone G, Pipas JM) Mol Cancer Res 2014 Oct;12(10):1355-64 PMID: 24994749 PMCID: PMC4201981 SCOPUS ID: 2-s2.0-84907994320 07/06/2014       3 Citations
  • Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis. (Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone G) Oncogene 2015 Jan 02;34(1):119-28 PMID: 24276244 PMCID: PMC4032808 SCOPUS ID: 2-s2.0-84964314758 11/28/2013       27 Citations
  • Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. (Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MC) PLoS One 2013;8(8):e71533 PMID: 23977064 PMCID: PMC3745457 SCOPUS ID: 2-s2.0-84881561093 08/27/2013       32 Citations
  • Evidence for a stepwise program of extrathymic T cell development within the human tonsil. (McClory S, Hughes T, Freud AG, Briercheck EL, Martin C, Trimboli AJ, Yu J, Zhang X, Leone G, Nuovo G, Caligiuri MA) J Clin Invest 2012 Apr;122(4):1403-15 PMID: 22378041 PMCID: PMC3314444 SCOPUS ID: 2-s2.0-84858793590 03/02/2012       69 Citations
  • Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. (Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC) Nat Cell Biol 2011 Dec 18;14(2):159-67 PMID: 22179046 PMCID: PMC3271169 SCOPUS ID: 2-s2.0-84856464305 12/20/2011       242 Citations
  • The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. (Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI) Oncogene 2010 Sep 09;29(36):5103-12 PMID: 20581865 PMCID: PMC2972189 SCOPUS ID: 2-s2.0-77956627154 06/29/2010       70 Citations
  • Pten in stromal fibroblasts suppresses mammary epithelial tumours. (Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G) Nature 2009 Oct 22;461(7267):1084-91 PMID: 19847259 PMCID: PMC2767301 SCOPUS ID: 2-s2.0-70350510924 10/23/2009       438 Citations
  • Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition. (Nadella KS, Jones GN, Trimboli A, Stratakis CA, Leone G, Kirschner LS) Cancer Res 2008 Apr 15;68(8):2671-7 PMID: 18413734 PMCID: PMC3129546 SCOPUS ID: 2-s2.0-42349115928 04/17/2008       31 Citations
  • Direct evidence for epithelial-mesenchymal transitions in breast cancer. (Trimboli AJ, Fukino K, de Bruin A, Wei G, Shen L, Tanner SM, Creasap N, Rosol TJ, Robinson ML, Eng C, Ostrowski MC, Leone G) Cancer Res 2008 Feb 01;68(3):937-45 PMID: 18245497 SCOPUS ID: 2-s2.0-38849093994 02/05/2008       315 Citations
  • Extra-embryonic function of Rb is essential for embryonic development and viability. (Wu L, de Bruin A, Saavedra HI, Starovic M, Trimboli A, Yang Y, Opavska J, Wilson P, Thompson JC, Ostrowski MC, Rosol TJ, Woollett LA, Weinstein M, Cross JC, Robinson ML, Leone G) Nature 2003 Feb 27;421(6926):942-7 PMID: 12607001 SCOPUS ID: 2-s2.0-0037468222 02/28/2003       327 Citations
  • Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells. (Clay CE, Namen AM, Atsumi G, Trimboli AJ, Fonteh AN, High KP, Chilton FH) J Investig Med 2001 Sep;49(5):413-20 PMID: 11523697 SCOPUS ID: 2-s2.0-0034889267 08/29/2001       63 Citations
  • Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells. (Trimboli AJ, Waite BM, Atsumi G, Fonteh AN, Namen AM, Clay CE, Kute TE, High KP, Willingham MC, Chilton FH) Cancer Res 1999 Dec 15;59(24):6171-7 PMID: 10626809 SCOPUS ID: 2-s2.0-0033572353 01/08/2000       29 Citations
  • Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells. (Clay CE, Namen AM, Atsumi G, Willingham MC, High KP, Kute TE, Trimboli AJ, Fonteh AN, Dawson PA, Chilton FH) Carcinogenesis 1999 Oct;20(10):1905-11 PMID: 10506103 SCOPUS ID: 2-s2.0-0032884254 10/03/1999       171 Citations
  • Hemoflavoprotein production using chemical cross-linking (Trimboli AJ, Barber MJ) FASEB Journal 1997;11(9) SCOPUS ID: 2-s2.0-33750281441 12/01/1997    
  • Direct electrochemistry of the flavin domain of assimilatory nitrate reductase: effects of NAD+ and NAD+ analogs. (Barber MJ, Trimboli AJ, Nomikos S, Smith ET) Arch Biochem Biophys 1997 Sep 01;345(1):88-96 PMID: 9281315 SCOPUS ID: 2-s2.0-0031239840 09/01/1997       14 Citations
  • Site-directed mutagenesis of thiol residues in the flavin domain of nitrate reductase (Trimboli AJ, Ouinn OS, Barber MJ) FASEB Journal 1996;10(6) SCOPUS ID: 2-s2.0-33749147000 12/01/1996    
  • Direct voltammetry of the flavin domain of nitrate reductase (Barber MJ, Trimboli AJ, Nimikos S, Smith ET) FASEB Journal 1996;10(6) SCOPUS ID: 2-s2.0-33749152329 12/01/1996    
  • Bacterial expression of the flavin/heme domain of spinach nitrate reductase (Osborne A, Trimboli AJ, Ouinn GB, Barber MJ) FASEB Journal 1996;10(6) SCOPUS ID: 2-s2.0-33749119144 12/01/1996    
  • Thiol modification and site directed mutagenesis of the flavin domain of spinach NADH:nitrate reductase. (Trimboli AJ, Quinn GB, Smith ET, Barber MJ) Arch Biochem Biophys 1996 Jul 01;331(1):117-26 PMID: 8660690 SCOPUS ID: 2-s2.0-0030200278 07/01/1996       20 Citations
  • Spectroscopic and kinetic properties of a recombinant form of the flavin domain of spinach NADH: nitrate reductase. (Quinn GB, Trimboli AJ, Prosser IM, Barber MJ) Arch Biochem Biophys 1996 Mar 01;327(1):151-60 PMID: 8615685 SCOPUS ID: 2-s2.0-0030062088 03/01/1996       15 Citations
  • The amino acid sequence of Rhodobacter sphaeroides dimethyl sulfoxide reductase. (Barber MJ, Van Valkenburgh H, Trimboli AJ, Pollock VV, Neame PJ, Bastian NR) Arch Biochem Biophys 1995 Jul 10;320(2):266-75 PMID: 7625833 SCOPUS ID: 2-s2.0-0029036141 07/10/1995       14 Citations
  • Assimilatory nitrate reductase: reduction and inhibition by NADH/NAD+ analogs. (Trimboli AJ, Barber MJ) Arch Biochem Biophys 1994 Nov 15;315(1):48-53 PMID: 7979404 SCOPUS ID: 2-s2.0-0027975423 11/15/1994       13 Citations
  • Construction and expression of a flavocytochrome b5 chimera. (Quinn GB, Trimboli AJ, Barber MJ) J Biol Chem 1994 May 06;269(18):13375-81 PMID: 8175767 SCOPUS ID: 2-s2.0-0028229514 05/06/1994       9 Citations
  • The amino acid sequence of Pseudomonas putida azurin. (Barber MJ, Trimboli AJ, McIntire WS) Arch Biochem Biophys 1993 May 15;303(1):22-6 PMID: 8489263 SCOPUS ID: 2-s2.0-0027180275 05/15/1993       6 Citations
  • Purification and properties of Alligator mississipiensis cytochrome c. (Barber MJ, Trimboli AJ, Clark M, Young C, Neame PJ) Arch Biochem Biophys 1993 Mar;301(2):294-8 PMID: 8384830 SCOPUS ID: 2-s2.0-0027293052 03/01/1993       3 Citations
    • Last update: 11/09/2022