Medical College of Wisconsin
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Brian L. Lin PhD

Brian L. Lin PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Cell Biology Neurobiology and Anatomy

Member of the Cardiovascular Research Center

View Curriculum Vitae

Publications (27)

  • Runx1 in Postn-Expressing Fibroblasts But Not Cardiomyocytes Exacerbates Adverse Cardiac Remodeling Post-Myocardial Infarction. (Akins KA, Arkatkar A, Flinn MA, Sandor N, Purdy AL, Brusacoram AL, Swift SK, Buday S, Choudhury P, Cui M, Lin BL, O'Meara CC, Patterson M) JACC Basic Transl Sci 2026 Feb;11(2):101455 PMID: 41534459 PMCID: PMC12830150 SCOPUS ID: 2-s2.0-105027428206 01/15/2026       1 Citation
  • GSNOR deletion differentially alters age-related cardiac function in a sex-dependent manner. (Ebenebe OV, Kabir R, Booher A, Garbus H, Cohen CD, Jani V, Lin BL, Adamo L, Kohr MJ) Am J Physiol Heart Circ Physiol 2026 Jan 01;330(1):H253-H264 PMID: 41407313 PMCID: PMC12954546 SCOPUS ID: 2-s2.0-105026900143 12/18/2025    
  • Role of the Renin-Angiotensin System in Blood Pressure Regulation in Smooth Muscle-Specific Cullin-3 Deficient Mice. (Golosova D, Kumar G, Chaihongsa N, Reho JJ, Lu KT, Brozoski DT, Wackman KK, Lawton SBR, Muskus PC, Lin BL, Grobe JL, Nakagawa P, Sigmund CD) Hypertension 2025 Jul;82(7):1208-1220 PMID: 40440505 PMCID: PMC12176512 SCOPUS ID: 2-s2.0-105005164668 05/29/2025       2 Citations
  • Gestational arsenite exposure alters maternal postpartum heart size and induces Ca2+-handling dysregulation in cardiomyocytes. (Taube N, Steiner M, Ebenebe-Kasonde OV, Kabir R, Garbus-Grant H, Alam El Din SM, Illingworth E, Wang N, Lin BL, Kohr MJ) Am J Physiol Heart Circ Physiol 2025 Mar 01;328(3):H460-H471 PMID: 39888327 PMCID: PMC12226173 SCOPUS ID: 2-s2.0-85219086993 01/31/2025    
  • A transcriptional enhancer regulates cardiac maturation. (Htet M, Lei S, Bajpayi S, Gangrade H, Arvanitis M, Zoitou A, Murphy S, Chen EZ, Koleini N, Lin BL, Kwon C, Tampakakis E) Nat Cardiovasc Res 2024 Jun;3(6):666-684 PMID: 39196225 PMCID: PMC12306338 SCOPUS ID: 2-s2.0-85194721283 08/28/2024       5 Citations
  • ATP Citrate Lyase Supports Cardiac Function and NAD+/NADH Balance And Is Depressed in Human Heart Failure. (Meddeb M, Koleini N, Jun S, Keykhaei M, Farshidfar F, Zhao L, Kwon S, Lin B, Keceli G, Paolocci N, Hahn V, Sharma K, Pearce EL, Kass DA) bioRxiv 2024 Jun 10 PMID: 38915649 PMCID: PMC11195057 06/25/2024    
  • Potential limitations of microdystrophin gene therapy for Duchenne muscular dystrophy. (Hart CC, Lee YI, Xie J, Gao G, Lin BL, Hammers DW, Sweeney HL) JCI Insight 2024 May 07;9(11) PMID: 38713520 PMCID: PMC11382885 SCOPUS ID: 2-s2.0-85195630545 05/07/2024       29 Citations
  • Hypereosinophilia causes progressive cardiac pathologies in mice. (Diny NL, Wood MK, Won T, Talor MV, Lukban C, Bedja D, Wang N, Kalinoski H, Daoud A, Talbot CC Jr, Leei Lin B, Čiháková D) iScience 2023 Oct 20;26(10):107990 PMID: 37829205 PMCID: PMC10565781 SCOPUS ID: 2-s2.0-85173471236 10/13/2023       5 Citations
  • An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor. (Reyes Gaido OE, Pavlaki N, Granger JM, Mesubi OO, Liu B, Lin BL, Long A, Walker D, Mayourian J, Schole KL, Terrillion CE, Nkashama LJ, Hulsurkar MM, Dorn LE, Ferrero KM, Huganir RL, Müller FU, Wehrens XHT, Liu JO, Luczak ED, Bezzerides VJ, Anderson ME) Sci Transl Med 2023 Jun 21;15(701):eabq7839 PMID: 37343080 PMCID: PMC11022683 SCOPUS ID: 2-s2.0-85163061900 06/21/2023       48 Citations
  • Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function. (Fitch ML, Kabir R, Ebenebe OV, Taube N, Garbus H, Sinha P, Wang N, Mishra S, Lin BL, Muller GK, Kohr MJ) Life Sci 2023 Jul 01;324:121712 PMID: 37100378 PMCID: PMC10246466 SCOPUS ID: 2-s2.0-85153605198 04/27/2023       13 Citations
  • Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes. (Kannan S, Miyamoto M, Zhu R, Lynott M, Guo J, Chen EZ, Colas AR, Lin BL, Kwon C) Cell Rep 2023 Apr 25;42(4):112330 PMID: 37014753 PMCID: PMC10545814 SCOPUS ID: 2-s2.0-85151483168 04/05/2023       10 Citations
  • Pharmacological TRPC6 inhibition improves survival and muscle function in mice with Duchenne muscular dystrophy. (Lin BL, Shin JY, Jeffreys WP, Wang N, Lukban CA, Moorer MC, Velarde E, Hanselman OA, Kwon S, Kannan S, Riddle RC, Ward CW, Pullen SS, Filareto A, Kass DA) JCI Insight 2022 Oct 10;7(19) PMID: 36099033 PMCID: PMC9675567 SCOPUS ID: 2-s2.0-85139571501 09/14/2022       17 Citations
  • Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy. (Boyer JG, Huo J, Han S, Havens JR, Prasad V, Lin BL, Kass DA, Song T, Sadayappan S, Khairallah RJ, Ward CW, Molkentin JD) Nat Commun 2022 May 26;13(1):2940 PMID: 35618700 PMCID: PMC9135721 SCOPUS ID: 2-s2.0-85130718478 05/27/2022       39 Citations
  • Heart neurons use clock genes to control myocyte proliferation. (Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G, Minichiello L, Kwon C) Sci Adv 2021 Dec 03;7(49):eabh4181 PMID: 34851661 PMCID: PMC8635446 SCOPUS ID: 2-s2.0-85120689228 12/02/2021       32 Citations
  • Transcriptomic entropy benchmarks stem cell-derived cardiomyocyte maturation against endogenous tissue at single cell level. (Kannan S, Farid M, Lin BL, Miyamoto M, Kwon C) PLoS Comput Biol 2021 Sep;17(9):e1009305 PMID: 34534204 PMCID: PMC8448341 SCOPUS ID: 2-s2.0-85115404050 09/18/2021       30 Citations
  • Single cell RNA-seq analysis of the flexor digitorum brevis mouse myofibers. (Verma RX, Kannan S, Lin BL, Fomchenko KM, Nieuwenhuis TO, Patil AH, Lukban C, Yang X, Fox-Talbot K, McCall MN, Kwon C, Kass DA, Rosenberg AZ, Halushka MK) Skelet Muscle 2021 May 17;11(1):13 PMID: 34001262 PMCID: PMC8127317 SCOPUS ID: 2-s2.0-85105889249 05/19/2021       3 Citations
  • HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics. (Chan XY, Volkova E, Eoh J, Black R, Fang L, Gorashi R, Song J, Wang J, Elliott MB, Barreto-Ortiz SF, Chen J, Lin BL, Santhanam L, Cheng L, Lee FS, Prchal JT, Gerecht S) iScience 2021 Apr 23;24(4):102246 PMID: 33796838 PMCID: PMC7995528 SCOPUS ID: 2-s2.0-85102565837 04/03/2021       22 Citations
  • Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility. (Lynch TL 4th, Kumar M, McNamara JW, Kuster DWD, Sivaguru M, Singh RR, Previs MJ, Lee KH, Kuffel G, Zilliox MJ, Lin BL, Ma W, Gibson AM, Blaxall BC, Nieman ML, Lorenz JN, Leichter DM, Leary OP, Janssen PML, de Tombe PP, Gilbert RJ, Craig R, Irving T, Warshaw DM, Sadayappan S) J Mol Cell Cardiol 2021 Jul;156:33-44 PMID: 33781820 PMCID: PMC8217138 SCOPUS ID: 2-s2.0-85103416245 03/31/2021       21 Citations
  • PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. (Murphy SA, Miyamoto M, Kervadec A, Kannan S, Tampakakis E, Kambhampati S, Lin BL, Paek S, Andersen P, Lee DI, Zhu R, An SS, Kass DA, Uosaki H, Colas AR, Kwon C) Nat Commun 2021 Mar 12;12(1):1648 PMID: 33712605 PMCID: PMC7955035 SCOPUS ID: 2-s2.0-85102485873 03/14/2021       72 Citations
  • Pulmonary artery pulsatility index predicts right ventricular myofilament dysfunction in advanced human heart failure. (Aslam MI, Jani V, Lin BL, Dunkerly-Eyring B, Livingston CE, Ramachandran A, Ranek MJ, Bedi KC, Margulies KB, Kass DA, Hsu S) Eur J Heart Fail 2021 Feb;23(2):339-341 PMID: 33347674 PMCID: PMC8574988 SCOPUS ID: 2-s2.0-85099065479 12/22/2020       27 Citations
  • Spatial Proteomic Approach to Characterize Skeletal Muscle Myofibers. (Fomchenko KM, Walsh EM, Yang X, Verma RX, Lin BL, Nieuwenhuis TO, Patil AH, Fox-Talbot K, McCall MN, Kass DA, Rosenberg AZ, Halushka MK) J Proteome Res 2021 Jan 01;20(1):888-894 PMID: 33251806 PMCID: PMC8826490 SCOPUS ID: 2-s2.0-85097798734 12/01/2020       12 Citations
  • PKG1α Cysteine-42 Redox State Controls mTORC1 Activation in Pathological Cardiac Hypertrophy. (Oeing CU, Nakamura T, Pan S, Mishra S, Dunkerly-Eyring BL, Kokkonen-Simon KM, Lin BL, Chen A, Zhu G, Bedja D, Lee DI, Kass DA, Ranek MJ) Circ Res 2020 Jul 31;127(4):522-533 PMID: 32393148 PMCID: PMC7416445 SCOPUS ID: 2-s2.0-85089301556 05/13/2020       45 Citations
  • Large Particle Fluorescence-Activated Cell Sorting Enables High-Quality Single-Cell RNA Sequencing and Functional Analysis of Adult Cardiomyocytes. (Kannan S, Miyamoto M, Lin BL, Zhu R, Murphy S, Kass DA, Andersen P, Kwon C) Circ Res 2019 Aug 16;125(5):567-569 PMID: 31415233 PMCID: PMC6699769 SCOPUS ID: 2-s2.0-85071578528 08/16/2019       35 Citations
  • In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease. (Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT, Chong JA, Hessler DP, Bedja D, Zhu G, Muller GK, Ranek MJ, Pantages L, McFarland M, Netherton MR, Berry A, Wong D, Rast G, Qian HS, Weldon SM, Kuo JJ, Sauer A, Sarko C, Moran MM, Kass DA, Pullen SS) Proc Natl Acad Sci U S A 2019 May 14;116(20):10156-10161 PMID: 31028142 PMCID: PMC6525474 SCOPUS ID: 2-s2.0-85065721210 04/28/2019       130 Citations
  • Chronic Atrial and Ventricular Pacing in the Mouse. (Ståhlberg M, Nakagawa R, Bedja D, Zhu G, Lin BL, Saberi A, Lee DI, Kass DA) Circ Heart Fail 2019 Feb;12(2):e005655 PMID: 30764638 PMCID: PMC6513021 SCOPUS ID: 2-s2.0-85061561894 02/16/2019       20 Citations
  • Skeletal myosin binding protein-C isoforms regulate thin filament activity in a Ca2+-dependent manner. (Lin BL, Li A, Mun JY, Previs MJ, Previs SB, Campbell SG, Dos Remedios CG, Tombe PP, Craig R, Warshaw DM, Sadayappan S) Sci Rep 2018 Feb 08;8(1):2604 PMID: 29422607 PMCID: PMC5805719 SCOPUS ID: 2-s2.0-85041809111 02/10/2018       41 Citations
  • Myofilaments: Movers and Rulers of the Sarcomere. (Lin BL, Song T, Sadayappan S) Compr Physiol 2017 Mar 16;7(2):675-692 PMID: 28333386 SCOPUS ID: 2-s2.0-85021039448 03/24/2017       34 Citations
    • Last update: 04/07/2026