Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Christopher Dockendorff PhD

Christopher Dockendorff PhD profile photo picture

Assistant Professor, Organic and Medicinal Chemistry

Institution: Marquette University
Department: Chemistry


Research Experience

  • Analgesics, Opioid
  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticarcinogenic Agents
  • Anticoagulants
  • Chemistry
  • Molecular Probes
  • Potassium Channel Blockers
  • Reperfusion Injury
  • Structure-Activity Relationship
  • Thrombosis
  • Publications (20)

  • A thrombin-PAR1/2 feedback loop amplifies thromboinflammatory endothelial responses to the viral RNA analogue poly(I:C). (Subramaniam S, Ogoti Y, Hernandez I, Zogg M, Botros F, Burns R, DeRousse JT, Dockendorff C, Mackman N, Antoniak S, Fletcher C, Weiler H) Blood Adv 2021 Jul 13;5(13):2760-2774 PMID: 34242391 PMCID: PMC8288670 SCOPUS ID: 2-s2.0-85110116594 07/10/2021       9 Citations
  • Synthesis and initial pharmacology of dual-targeting ligands for putative complexes of integrin αVβ3 and PAR2. (Majewski MW, Gandhi DM, Holyst T, Wang Z, Hernandez I, Rosas R Jr, Zhu J, Weiler H, Dockendorff C) RSC Med Chem 2020 Aug 01;11(8):940-949 PMID: 33479689 PMCID: PMC7496306 SCOPUS ID: 2-s2.0-85091019890 01/23/2021       1 Citation
  • Route exploration and synthesis of the reported pyridone-based PDI inhibitor STK076545. (Greve E, Lindeman SV, Scartelli C, Lin L, Flaumenhaft R, Dockendorff C) Org Biomol Chem 2020 Sep 14;18(34):6665-6681 PMID: 32812971 PMCID: PMC7899705 SCOPUS ID: 2-s2.0-85090252484 08/20/2020       4 Citations
  • Modified Synthesis of the Peptidomimetic Natriuretic Peptide Receptor-C Antagonist M372049. (Porter JD, Lindeman SV, Dockendorff C) Tetrahedron Lett 2020 Mar 19;61(12) PMID: 32153307 PMCID: PMC7062365 SCOPUS ID: 2-s2.0-85078305329 03/11/2020       1 Citation
  • An anthrone-based Kv7.2/7.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders. (Porter JD, Vivas O, Weaver CD, Alsafran A, DiMilo E, Arnold LA, Dickson EJ, Dockendorff C) Bioorg Med Chem Lett 2019 Dec 01;29(23):126681 PMID: 31668424 PMCID: PMC6858848 SCOPUS ID: 2-s2.0-85074462524 11/02/2019       4 Citations
  • β-Fluorofentanyls Are pH-Sensitive Mu Opioid Receptor Agonists. (Rosas R Jr, Huang XP, Roth BL, Dockendorff C) ACS Med Chem Lett 2019 Sep 12;10(9):1353-1356 PMID: 31531209 PMCID: PMC6746189 SCOPUS ID: 2-s2.0-85071673839 09/19/2019       14 Citations
  • Evaluation of α-hydroxycinnamic acids as pyruvate carboxylase inhibitors. (Burkett DJ, Wyatt BN, Mews M, Bautista A, Engel R, Dockendorff C, Donaldson WA, St Maurice M) Bioorg Med Chem 2019 Sep 15;27(18):4041-4047 PMID: 31351848 SCOPUS ID: 2-s2.0-85070969158 07/29/2019       4 Citations
  • The parmodulin NRD-21 is an allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability. (Gandhi DM, Rosas R Jr, Greve E, Kentala K, D-R Diby N, Snyder VA, Stephans A, Yeung THW, Subramaniam S, DiMilo E, Kurtenbach KE, Arnold LA, Weiler H, Dockendorff C) Bioorg Med Chem 2019 Sep 01;27(17):3788-3796 PMID: 31320211 PMCID: PMC6706283 SCOPUS ID: 2-s2.0-85068855508 07/20/2019       4 Citations
  • NMR Structural Analysis of Isolated Shaker Voltage-Sensing Domain in LPPG Micelles. (Chen H, Pan J, Gandhi DM, Dockendorff C, Cui Q, Chanda B, Henzler-Wildman KA) Biophys J 2019 Jul 23;117(2):388-398 PMID: 31301804 PMCID: PMC6702147 SCOPUS ID: 2-s2.0-85068530975 07/16/2019       3 Citations
  • Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents. (Wu Y, Dockendorff C) J Org Chem 2019 May 03;84(9):5292-5304 PMID: 30919633 SCOPUS ID: 2-s2.0-85065173114 03/29/2019       6 Citations
  • Design and Evaluation of Heterobivalent PAR1-PAR2 Ligands as Antagonists of Calcium Mobilization. (Majewski MW, Gandhi DM, Rosas R Jr, Kodali R, Arnold LA, Dockendorff C) ACS Med Chem Lett 2019 Jan 10;10(1):121-126 PMID: 30655958 PMCID: PMC6331166 SCOPUS ID: 2-s2.0-85058668129 01/19/2019       9 Citations
  • Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells. (Gandhi DM, Majewski MW, Rosas R Jr, Kentala K, Foster TJ, Greve E, Dockendorff C) Bioorg Med Chem 2018 May 15;26(9):2514-2529 PMID: 29685684 PMCID: PMC5937995 SCOPUS ID: 2-s2.0-85045909279 04/25/2018       11 Citations
  • Synthetic Analogues of the Snail Toxin 6-Bromo-2-mercaptotryptamine Dimer (BrMT) Reveal That Lipid Bilayer Perturbation Does Not Underlie Its Modulation of Voltage-Gated Potassium Channels. (Dockendorff C, Gandhi DM, Kimball IH, Eum KS, Rusinova R, Ingólfsson HI, Kapoor R, Peyear T, Dodge MW, Martin SF, Aldrich RW, Andersen OS, Sack JT) Biochemistry 2018 May 08;57(18):2733-2743 PMID: 29616558 PMCID: PMC6007853 SCOPUS ID: 2-s2.0-85046628913 04/05/2018       15 Citations
  • PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury. (De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R) Proc Natl Acad Sci U S A 2018 Jan 30;115(5):E982-E991 PMID: 29343648 PMCID: PMC5798377 SCOPUS ID: 2-s2.0-85041197789 01/19/2018       49 Citations
  • Monitoring Replication Protein A (RPA) dynamics in homologous recombination through site-specific incorporation of non-canonical amino acids. (Pokhrel N, Origanti S, Davenport EP, Gandhi D, Kaniecki K, Mehl RA, Greene EC, Dockendorff C, Antony E) Nucleic Acids Res 2017 Sep 19;45(16):9413-9426 PMID: 28934470 PMCID: PMC5766198 SCOPUS ID: 2-s2.0-85031928912 09/22/2017       25 Citations
  • Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition. (Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K) Blood 2017 Dec 14;130(24):2664-2677 PMID: 28882883 PMCID: PMC5731086 SCOPUS ID: 2-s2.0-85031715669 09/09/2017       111 Citations
  • Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport. (Dockendorff C, Faloon PW, Yu M, Youngsaye W, Penman M, Nieland TJ, Nag PP, Lewis TA, Pu J, Bennion M, Negri J, Paterson C, Lam G, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M) ACS Med Chem Lett 2015 Apr 09;6(4):375-380 PMID: 26478787 PMCID: PMC4599563 SCOPUS ID: 2-s2.0-84927666208 10/20/2015       10 Citations
  • Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. (Dockendorff C, Faloon PW, Germain A, Yu M, Youngsaye W, Nag PP, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M) Bioorg Med Chem Lett 2015 Jun 15;25(12):2594-8 PMID: 25958245 PMCID: PMC4469081 SCOPUS ID: 2-s2.0-84929994575 05/11/2015       11 Citations
  • Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake. (Dockendorff C, Faloon PW, Pu J, Yu M, Johnston S, Bennion M, Penman M, Nieland TJ, Dandapani S, Perez JR, Munoz B, Palmer MA, Schreiber SL, Krieger M) Bioorg Med Chem Lett 2015;25(10):2100-5 PMID: 25900219 PMCID: PMC4469080 SCOPUS ID: 2-s2.0-84930004990 04/23/2015       13 Citations
  • Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. (Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R) Blood 2015 Mar 19;125(12):1976-85 PMID: 25587041 PMCID: PMC4366627 SCOPUS ID: 2-s2.0-84925359034 01/15/2015       69 Citations
  • Last update: 12/02/2021