Medical College of Wisconsin
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Christopher J. Kristich PhD

Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Center for Microbiome Research

View Curriculum Vitae

Publications (45)

  • PASTA-kinase-mediated signaling drives accumulation of the peptidoglycan synthesis protein MurAA to promote cephalosporin resistance in Enterococcus faecalis. (Mascari CA, Little JL, Kristich CJ) Mol Microbiol 2023 Dec;120(6):811-829 PMID: 37688380 PMCID: PMC10872757 SCOPUS ID: 2-s2.0-85170564562 09/09/2023       2 Citations
  • Multisite Phosphorylation Regulates GpsB Function in Cephalosporin Resistance of Enterococcus faecalis. (VanZeeland NE, Schultz KM, Klug CS, Kristich CJ) J Mol Biol 2023 Sep 15;435(18):168216 PMID: 37517789 PMCID: PMC10528945 SCOPUS ID: 2-s2.0-85166951228 07/31/2023       1 Citation
  • Conformational changes in the activation loop of a bacterial PASTA kinase. (Bluma MS, Schultz KM, Kristich CJ, Klug CS) Protein Sci 2023 Jul;32(7):e4697 PMID: 37312631 PMCID: PMC10303680 SCOPUS ID: 2-s2.0-85163810164 06/14/2023    
  • GpsB Promotes PASTA Kinase Signaling and Cephalosporin Resistance in Enterococcus faecalis. (Minton NE, Djorić D, Little J, Kristich CJ) J Bacteriol 2022 Oct 18;204(10):e0030422 PMID: 36094306 PMCID: PMC9578390 SCOPUS ID: 2-s2.0-85140274238 09/13/2022       7 Citations
  • CroR Regulates Expression of pbp4(5) to Promote Cephalosporin Resistance in Enterococcus faecalis. (Timmler SB, Kellogg SL, Atkinson SN, Little JL, Djorić D, Kristich CJ) mBio 2022 Aug 30;13(4):e0111922 PMID: 35913163 PMCID: PMC9426447 SCOPUS ID: 2-s2.0-85137010276 08/02/2022       2 Citations
  • Use of an Interspecies Chimeric Receptor for Inducible Gene Expression Reveals that Metabolic Flux through the Peptidoglycan Biosynthesis Pathway is an Important Driver of Cephalosporin Resistance in Enterococcus faecalis. (Mascari CA, Djorić D, Little JL, Kristich CJ) J Bacteriol 2022 Apr 19;204(4):e0060221 PMID: 35258319 PMCID: PMC9017299 SCOPUS ID: 2-s2.0-85128609674 03/09/2022       5 Citations
  • IreK-Mediated, Cell Wall-Protective Phosphorylation in Enterococcus faecalis. (Iannetta AA, Minton NE, Uitenbroek AA, Little JL, Stanton CR, Kristich CJ, Hicks LM) J Proteome Res 2021 Nov 05;20(11):5131-5144 PMID: 34672600 PMCID: PMC10037947 SCOPUS ID: 2-s2.0-85118785739 10/22/2021       7 Citations
  • The enterococcal PASTA kinase: A sentinel for cell envelope stress. (Djorić D, Minton NE, Kristich CJ) Mol Oral Microbiol 2021 Apr;36(2):132-144 PMID: 32945615 PMCID: PMC7969467 SCOPUS ID: 2-s2.0-85092077534 09/19/2020       6 Citations
  • Multiple Low-Reactivity Class B Penicillin-Binding Proteins Are Required for Cephalosporin Resistance in Enterococci. (Djorić D, Little JL, Kristich CJ) Antimicrob Agents Chemother 2020 Mar 24;64(4) PMID: 32041714 PMCID: PMC7179317 SCOPUS ID: 2-s2.0-85082388512 02/12/2020       16 Citations
  • Reciprocal Regulation of PASTA Kinase Signaling by Differential Modification. (Labbe BD, Hall CL, Kellogg SL, Chen Y, Koehn O, Pickrum AM, Mirza SP, Kristich CJ) J Bacteriol 2019 May 15;201(10) PMID: 30858297 PMCID: PMC6482931 SCOPUS ID: 2-s2.0-85065131964 03/13/2019       8 Citations
  • Sortase-Dependent Proteins Promote Gastrointestinal Colonization by Enterococci. (Banla LI, Pickrum AM, Hayward M, Kristich CJ, Salzman NH) Infect Immun 2019 Mar;87(5) PMID: 30804098 PMCID: PMC6479037 SCOPUS ID: 2-s2.0-85065021405 02/26/2019       11 Citations
  • Colonization of the mammalian intestinal tract by enterococci. (Banla LI, Salzman NH, Kristich CJ) Curr Opin Microbiol 2019 Feb;47:26-31 PMID: 30439685 PMCID: PMC6511500 SCOPUS ID: 2-s2.0-85056238106 11/16/2018       21 Citations
  • Ceftriaxone Administration Disrupts Intestinal Homeostasis, Mediating Noninflammatory Proliferation and Dissemination of Commensal Enterococci. (Chakraborty R, Lam V, Kommineni S, Stromich J, Hayward M, Kristich CJ, Salzman NH) Infect Immun 2018 Dec;86(12) PMID: 30224553 PMCID: PMC6246901 SCOPUS ID: 2-s2.0-85056802367 09/19/2018       28 Citations
  • Exploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1. (Kirkpatrick CL, Parsley NC, Bartges TE, Wing CE, Kommineni S, Kristich CJ, Salzman NH, Patrie SM, Hicks LM) Microb Biotechnol 2018 Sep;11(5):943-951 PMID: 30014612 PMCID: PMC6116741 SCOPUS ID: 2-s2.0-85050586641 07/18/2018       6 Citations
  • Convergence of PASTA Kinase and Two-Component Signaling in Response to Cell Wall Stress in Enterococcus faecalis. (Kellogg SL, Kristich CJ) J Bacteriol 2018 Jun 15;200(12) PMID: 29632091 PMCID: PMC5971478 SCOPUS ID: 2-s2.0-85047458915 04/11/2018       25 Citations
  • Modulators of Enterococcus faecalis Cell Envelope Integrity and Antimicrobial Resistance Influence Stable Colonization of the Mammalian Gastrointestinal Tract. (Banla IL, Kommineni S, Hayward M, Rodrigues M, Palmer KL, Salzman NH, Kristich CJ) Infect Immun 2018 Jan;86(1) PMID: 29038125 PMCID: PMC5736811 SCOPUS ID: 2-s2.0-85039561569 10/19/2017       21 Citations
  • Extracellular SalB Contributes to Intrinsic Cephalosporin Resistance and Cell Envelope Integrity in Enterococcus faecalis. (Djorić D, Kristich CJ) J Bacteriol 2017 Dec 01;199(23) PMID: 28874409 PMCID: PMC5686589 SCOPUS ID: 2-s2.0-85032975375 09/07/2017       5 Citations
  • Growth- and Stress-Induced PASTA Kinase Phosphorylation in Enterococcus faecalis. (Labbe BD, Kristich CJ) J Bacteriol 2017 Nov 01;199(21) PMID: 28808126 PMCID: PMC5626955 SCOPUS ID: 2-s2.0-85030528788 08/16/2017       25 Citations
  • Structure and Dimerization of IreB, a Negative Regulator of Cephalosporin Resistance in Enterococcus faecalis. (Hall CL, Lytle BL, Jensen D, Hoff JS, Peterson FC, Volkman BF, Kristich CJ) J Mol Biol 2017 Jul 21;429(15):2324-2336 PMID: 28551334 PMCID: PMC5527686 SCOPUS ID: 2-s2.0-85020666072 05/30/2017       13 Citations
  • Requirement of the CroRS Two-Component System for Resistance to Cell Wall-Targeting Antimicrobials in Enterococcus faecium. (Kellogg SL, Little JL, Hoff JS, Kristich CJ) Antimicrob Agents Chemother 2017 May;61(5) PMID: 28223383 PMCID: PMC5404561 SCOPUS ID: 2-s2.0-85018165537 02/23/2017       35 Citations
  • Harnessing bacteriocin biology as targeted therapy in the GI tract. (Kommineni S, Kristich CJ, Salzman NH) Gut Microbes 2016 Nov;7(6):512-517 PMID: 27624536 PMCID: PMC5153615 SCOPUS ID: 2-s2.0-84989252479 11/03/2016       15 Citations
  • Thymidylate Limitation Potentiates Cephalosporin Activity toward Enterococci via an Exopolysaccharide-Based Mechanism. (Hoff JS, Kristich CJ) ACS Chem Biol 2016 Jun 17;11(6):1561-8 PMID: 27008338 PMCID: PMC5238413 SCOPUS ID: 2-s2.0-84975251924 03/24/2016       8 Citations
  • Functional Dissection of the CroRS Two-Component System Required for Resistance to Cell Wall Stressors in Enterococcus faecalis. (Kellogg SL, Kristich CJ) J Bacteriol 2016 Apr;198(8):1326-36 PMID: 26883822 PMCID: PMC4859583 SCOPUS ID: 2-s2.0-84963807323 02/18/2016       26 Citations
  • Bacteriocin production augments niche competition by enterococci in the mammalian gastrointestinal tract. (Kommineni S, Bretl DJ, Lam V, Chakraborty R, Hayward M, Simpson P, Cao Y, Bousounis P, Kristich CJ, Salzman NH) Nature 2015 Oct 29;526(7575):719-22 PMID: 26479034 PMCID: PMC4978352 SCOPUS ID: 2-s2.0-84945964162 10/20/2015       295 Citations
  • Oxidative stress enhances cephalosporin resistance of Enterococcus faecalis through activation of a two-component signaling system. (Djorić D, Kristich CJ) Antimicrob Agents Chemother 2015 Jan;59(1):159-69 PMID: 25331701 PMCID: PMC4291345 SCOPUS ID: 2-s2.0-84920163536 10/22/2014       34 Citations
  • Genetic basis for vancomycin-enhanced cephalosporin susceptibility in vancomycin-resistant enterococci revealed using counterselection with dominant-negative thymidylate synthase. (Kristich CJ, Djorić D, Little JL) Antimicrob Agents Chemother 2014;58(3):1556-64 PMID: 24366749 PMCID: PMC3957902 SCOPUS ID: 2-s2.0-84896854268 12/25/2013       19 Citations
  • Nutritional control of antibiotic resistance via an interface between the phosphotransferase system and a two-component signaling system. (Snyder H, Kellogg SL, Skarda LM, Little JL, Kristich CJ) Antimicrob Agents Chemother 2014;58(2):957-65 PMID: 24277024 PMCID: PMC3910890 SCOPUS ID: 2-s2.0-84893482882 11/28/2013       31 Citations
  • IreB, a Ser/Thr kinase substrate, influences antimicrobial resistance in Enterococcus faecalis. (Hall CL, Tschannen M, Worthey EA, Kristich CJ) Antimicrob Agents Chemother 2013 Dec;57(12):6179-86 PMID: 24080657 PMCID: PMC3837872 SCOPUS ID: 2-s2.0-84887458824 10/02/2013       49 Citations
  • A Rex family transcriptional repressor influences H2O2 accumulation by Enterococcus faecalis. (Vesić D, Kristich CJ) J Bacteriol 2013 Apr;195(8):1815-24 PMID: 23417491 PMCID: PMC3624565 SCOPUS ID: 2-s2.0-84876088340 02/19/2013       51 Citations
  • Mutations in the β subunit of RNA polymerase alter intrinsic cephalosporin resistance in Enterococci. (Kristich CJ, Little JL) Antimicrob Agents Chemother 2012 Apr;56(4):2022-7 PMID: 22290974 PMCID: PMC3318385 SCOPUS ID: 2-s2.0-84858667570 02/01/2012       27 Citations
  • MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis. (Vesić D, Kristich CJ) Antimicrob Agents Chemother 2012 May;56(5):2443-51 PMID: 22290954 PMCID: PMC3346666 SCOPUS ID: 2-s2.0-84858689036 02/01/2012       35 Citations
  • Reciprocal regulation of cephalosporin resistance in Enterococcus faecalis. (Kristich CJ, Little JL, Hall CL, Hoff JS) mBio 2011;2(6):e00199-11 PMID: 22045988 PMCID: PMC3202758 SCOPUS ID: 2-s2.0-84855219477 11/03/2011       53 Citations
  • Functional genomics of Enterococcus faecalis: multiple novel genetic determinants for biofilm formation in the core genome. (Ballering KS, Kristich CJ, Grindle SM, Oromendia A, Beattie DT, Dunny GM) J Bacteriol 2009 Apr;191(8):2806-14 PMID: 19218379 PMCID: PMC2668403 SCOPUS ID: 2-s2.0-65249083873 02/17/2009       51 Citations
  • Development and use of an efficient system for random mariner transposon mutagenesis to identify novel genetic determinants of biofilm formation in the core Enterococcus faecalis genome. (Kristich CJ, Nguyen VT, Le T, Barnes AM, Grindle S, Dunny GM) Appl Environ Microbiol 2008 Jun;74(11):3377-86 PMID: 18408066 PMCID: PMC2423031 SCOPUS ID: 2-s2.0-44949129965 04/15/2008       80 Citations
  • A eukaryotic-type Ser/Thr kinase in Enterococcus faecalis mediates antimicrobial resistance and intestinal persistence. (Kristich CJ, Wells CL, Dunny GM) Proc Natl Acad Sci U S A 2007 Feb 27;104(9):3508-13 PMID: 17360674 PMCID: PMC1805595 SCOPUS ID: 2-s2.0-33847675357 03/16/2007       127 Citations
  • Development of a host-genotype-independent counterselectable marker and a high-frequency conjugative delivery system and their use in genetic analysis of Enterococcus faecalis. (Kristich CJ, Chandler JR, Dunny GM) Plasmid 2007 Mar;57(2):131-44 PMID: 16996131 PMCID: PMC1852458 SCOPUS ID: 2-s2.0-33846993832 09/26/2006       141 Citations
  • Development of a method for markerless genetic exchange in Enterococcus faecalis and its use in construction of a srtA mutant. (Kristich CJ, Manias DA, Dunny GM) Appl Environ Microbiol 2005 Oct;71(10):5837-49 PMID: 16204495 PMCID: PMC1265997 SCOPUS ID: 2-s2.0-26844580763 10/06/2005       54 Citations
  • High-resolution visualization of the microbial glycocalyx with low-voltage scanning electron microscopy: dependence on cationic dyes. (Erlandsen SL, Kristich CJ, Dunny GM, Wells CL) J Histochem Cytochem 2004 Nov;52(11):1427-35 PMID: 15505337 PMCID: PMC3957825 SCOPUS ID: 2-s2.0-8744254706 10/27/2004       138 Citations
  • Analysis of chimeric chemoreceptors in Bacillus subtilis reveals a role for CheD in the function of the McpC HAMP domain. (Kristich CJ, Ordal GW) J Bacteriol 2004 Sep;186(17):5950-5 PMID: 15317802 PMCID: PMC516843 SCOPUS ID: 2-s2.0-4344663857 08/20/2004       16 Citations
  • Esp-independent biofilm formation by Enterococcus faecalis. (Kristich CJ, Li YH, Cvitkovitch DG, Dunny GM) J Bacteriol 2004 Jan;186(1):154-63 PMID: 14679235 PMCID: PMC365672 SCOPUS ID: 2-s2.0-0346435112 12/18/2003       224 Citations
  • The conserved cytoplasmic module of the transmembrane chemoreceptor McpC mediates carbohydrate chemotaxis in Bacillus subtilis. (Kristich CJ, Glekas GD, Ordal GW) Mol Microbiol 2003 Mar;47(5):1353-66 PMID: 12603740 SCOPUS ID: 2-s2.0-0037340214 02/27/2003       32 Citations
  • Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis. (Kristich CJ, Ordal GW) J Biol Chem 2002 Jul 12;277(28):25356-62 PMID: 12011078 SCOPUS ID: 2-s2.0-0037067781 05/16/2002       56 Citations
  • CheC is related to the family of flagellar switch proteins and acts independently from CheD to control chemotaxis in Bacillus subtilis. (Kirby JR, Kristich CJ, Saulmon MM, Zimmer MA, Garrity LF, Zhulin IB, Ordal GW) Mol Microbiol 2001 Nov;42(3):573-85 PMID: 11722727 SCOPUS ID: 2-s2.0-0035168279 11/28/2001       53 Citations
  • CheY-dependent methylation of the asparagine receptor, McpB, during chemotaxis in Bacillus subtilis. (Kirby JR, Saulmon MM, Kristich CJ, Ordal GW) J Biol Chem 1999 Apr 16;274(16):11092-100 PMID: 10196193 SCOPUS ID: 2-s2.0-0033574575 04/10/1999       31 Citations
  • Methanol production during chemotaxis to amino acids in Bacillus subtilis. (Kirby JR, Kristich CJ, Feinberg SL, Ordal GW) Mol Microbiol 1997 May;24(4):869-78 PMID: 9194713 SCOPUS ID: 2-s2.0-0030905518 05/01/1997       27 Citations
    • Last update: 10/14/2023