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David N. Frick PhD

David N. Frick PhD profile photo picture

Associate Professor

Institution: University of Wisconsin - Milwaukee
Department: Chimistry & Biochemistry

View Curriculum Vitae

Publications (72)

  • Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice. (Belayet JB, Beamish S, Rahaman M, Alanani S, Virdi RS, Frick DN, Rahman AFMT, Ulicki JS, Biswas S, Arnold LA, Roni MSR, Cheng EY, Steeber DA, Frick KM, Hossain MM) J Med Chem 2022 Feb 24;65(4):3388-3403 PMID: 35133171 PMCID: PMC9135144 SCOPUS ID: 2-s2.0-85124901172 02/09/2022       2 Citations
  • A transplant recipient's pandemic perspective. (Frick DN) Transpl Infect Dis 2021 Oct;23(5):e13738 PMID: 34590768 PMCID: PMC8646248 SCOPUS ID: 2-s2.0-85116340090 10/01/2021       1 Citation
  • Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3. (Virdi RS, Bavisotto RV, Hopper NC, Vuksanovic N, Melkonian TR, Silvaggi NR, Frick DN) SLAS Discov 2020 Dec;25(10):1162-1170 PMID: 32981460 PMCID: PMC7684785 SCOPUS ID: 2-s2.0-85091680237 09/29/2020       22 Citations
  • Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3. (Virdi RS, Bavisotto RV, Hopper NC, Vuksanovic N, Melkonian TR, Silvaggi NR, Frick DN) bioRxiv 2020 Sep 01 PMID: 32676591 PMCID: PMC7359513 07/18/2020    
  • Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3. (Frick DN, Virdi RS, Vuksanovic N, Dahal N, Silvaggi NR) Biochemistry 2020 Jul 21;59(28):2608-2615 PMID: 32578982 PMCID: PMC7341687 SCOPUS ID: 2-s2.0-85088493564 06/25/2020       70 Citations
  • Fluorescent probe displacement assays reveal unique nucleic acid binding properties of human nudix enzymes. (Ray A, Frick DN) Anal Biochem 2020 Apr 15;595:113622 PMID: 32059949 PMCID: PMC7087442 SCOPUS ID: 2-s2.0-85079386232 02/16/2020       6 Citations
  • New Techniques to Study Intracellular Receptors in Living Cells: Insights Into RIG-I-Like Receptor Signaling. (Corby MJ, Raicu V, Frick DN) Adv Exp Med Biol 2019;1111:219-240 PMID: 30471070 PMCID: PMC8538538 SCOPUS ID: 2-s2.0-85078838541 11/25/2018       1 Citation
  • Role of the Conserved DECH-Box Cysteine in Coupling Hepatitis C Virus Helicase-Catalyzed ATP Hydrolysis to RNA Unwinding. (Yerukhimovich MM, Marohnic CC, Frick DN) Biochemistry 2018 Oct 30;57(43):6247-6255 PMID: 30281972 PMCID: PMC8532174 SCOPUS ID: 2-s2.0-85055137056 10/04/2018       1 Citation
  • Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells. (Corby MJ, Stoneman MR, Biener G, Paprocki JD, Kolli R, Raicu V, Frick DN) J Biol Chem 2017 Jul 07;292(27):11165-11177 PMID: 28483922 PMCID: PMC5500786 SCOPUS ID: 2-s2.0-85023595295 05/10/2017       7 Citations
  • Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV. (Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A) Bioorg Med Chem Lett 2017 Feb 15;27(4):936-940 PMID: 28089348 SCOPUS ID: 2-s2.0-85009518348 01/17/2017       10 Citations
  • Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents. (Bassetto M, Ferla S, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, O'Donnell R, Brancale A) Antivir Chem Chemother 2015 Dec;24(5-6):155-160 PMID: 27815332 PMCID: PMC5890509 SCOPUS ID: 2-s2.0-85007227730 11/07/2016       1 Citation
  • In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase. (Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Courtney-Smith M, Brancale A) Eur J Med Chem 2017 Jan 05;125:1115-1131 PMID: 27810598 SCOPUS ID: 2-s2.0-84994045444 11/05/2016       15 Citations
  • Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. (Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A) Eur J Med Chem 2016 Nov 10;123:31-47 PMID: 27474921 SCOPUS ID: 2-s2.0-84979632753 07/31/2016       25 Citations
  • Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents. (Kaushik-Basu N, Ratmanova NK, Manvar D, Belov DS, Cevik O, Basu A, Yerukhimovich MM, Lukyanenko ER, Andreev IA, Belov GM, Manfroni G, Cecchetti V, Frick DN, Kurkin AV, Altieri A, Barreca ML) Eur J Med Chem 2016 Oct 21;122:319-325 PMID: 27376494 SCOPUS ID: 2-s2.0-84976871014 07/05/2016       7 Citations
  • Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient. (Provazzi PJ, Mukherjee S, Hanson AM, Nogueira ML, Carneiro BM, Frick DN, Rahal P) PLoS One 2015;10(12):e0144638 PMID: 26658750 PMCID: PMC4684341 SCOPUS ID: 2-s2.0-84955595604 12/15/2015       2 Citations
  • Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase. (Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN) ACS Infect Dis 2015 Mar 13;1(3):140-148 PMID: 26029739 PMCID: PMC4444071 SCOPUS ID: 2-s2.0-84969213558 06/02/2015       41 Citations
  • Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy. (Ndjomou J, Corby MJ, Sweeney NL, Hanson AM, Aydin C, Ali A, Schiffer CA, Li K, Frankowski KJ, Schoenen FJ, Frick DN) ACS Chem Biol 2015 Aug 21;10(8):1887-96 PMID: 25961497 PMCID: PMC4546510 SCOPUS ID: 2-s2.0-84939797992 05/12/2015       7 Citations
  • Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold. (Andreev IA, Manvar D, Barreca ML, Belov DS, Basu A, Sweeney NL, Ratmanova NK, Lukyanenko ER, Manfroni G, Cecchetti V, Frick DN, Altieri A, Kaushik-Basu N, Kurkin AV) Eur J Med Chem 2015;96:250-8 PMID: 25890075 PMCID: PMC5557381 SCOPUS ID: 2-s2.0-84927631948 04/19/2015       23 Citations
  • Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication. (Mukherjee S, Weiner WS, Schroeder CE, Simpson DS, Hanson AM, Sweeney NL, Marvin RK, Ndjomou J, Kolli R, Isailovic D, Schoenen FJ, Frick DN) ACS Chem Biol 2014 Oct 17;9(10):2393-403 PMID: 25126694 PMCID: PMC4201343 SCOPUS ID: 2-s2.0-84908215132 08/16/2014       65 Citations
  • The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities. (Aydin C, Mukherjee S, Hanson AM, Frick DN, Schiffer CA) Protein Sci 2013 Dec;22(12):1786-98 PMID: 24123290 PMCID: PMC3843632 SCOPUS ID: 2-s2.0-84892910710 10/15/2013       18 Citations
  • Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP. (Shadrick WR, Mukherjee S, Hanson AM, Sweeney NL, Frick DN) Biochemistry 2013 Sep 10;52(36):6151-9 PMID: 23947785 PMCID: PMC4272346 SCOPUS ID: 2-s2.0-84884253048 08/21/2013       32 Citations
  • Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis. (Sweeney NL, Shadrick WR, Mukherjee S, Li K, Frankowski KJ, Schoenen FJ, Frick DN) J Biol Chem 2013 Jul 05;288(27):19949-57 PMID: 23703611 PMCID: PMC3707695 SCOPUS ID: 2-s2.0-84880077036 05/25/2013       9 Citations
  • An ire1-phk1 chimera reveals a dispensable role of autokinase activity in endoplasmic reticulum stress response. (Mannan MA, Shadrick WR, Biener G, Shin BS, Anshu A, Raicu V, Frick DN, Dey M) J Mol Biol 2013 Jun 26;425(12):2083-99 PMID: 23541589 SCOPUS ID: 2-s2.0-84878233437 04/02/2013       16 Citations
  • Discovering new medicines targeting helicases: challenges and recent progress. (Shadrick WR, Ndjomou J, Kolli R, Mukherjee S, Hanson AM, Frick DN) J Biomol Screen 2013 Aug;18(7):761-81 PMID: 23536547 PMCID: PMC4427233 SCOPUS ID: 2-s2.0-84880836962 03/29/2013       84 Citations
  • Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation. (Ndjomou J, Kolli R, Mukherjee S, Shadrick WR, Hanson AM, Sweeney NL, Bartczak D, Li K, Frankowski KJ, Schoenen FJ, Frick DN) Antiviral Res 2012 Nov;96(2):245-55 PMID: 22940425 PMCID: PMC3571690 SCOPUS ID: 2-s2.0-84867418390 09/04/2012       18 Citations
  • Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays. (Mukherjee S, Hanson AM, Shadrick WR, Ndjomou J, Sweeney NL, Hernandez JJ, Bartczak D, Li K, Frankowski KJ, Heck JA, Arnold LA, Schoenen FJ, Frick DN) Nucleic Acids Res 2012 Sep 01;40(17):8607-21 PMID: 22740655 PMCID: PMC3458564 SCOPUS ID: 2-s2.0-84866952771 06/29/2012       48 Citations
  • Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase. (Hanson AM, Hernandez JJ, Shadrick WR, Frick DN) Methods Enzymol 2012;511:463-83 PMID: 22713333 PMCID: PMC3571682 SCOPUS ID: 2-s2.0-84862994750 06/21/2012       19 Citations
  • Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. (Mastrangelo E, Pezzullo M, De Burghgraeve T, Kaptein S, Pastorino B, Dallmeier K, de Lamballerie X, Neyts J, Hanson AM, Frick DN, Bolognesi M, Milani M) J Antimicrob Chemother 2012 Aug;67(8):1884-94 PMID: 22535622 PMCID: PMC3888155 SCOPUS ID: 2-s2.0-84864523421 04/27/2012       292 Citations
  • Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. (Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN) J Med Chem 2012 Apr 12;55(7):3319-30 PMID: 22409723 PMCID: PMC3476947 SCOPUS ID: 2-s2.0-84859790281 03/14/2012       63 Citations
  • Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. (Peng LF, Schaefer EA, Maloof N, Skaff A, Berical A, Belon CA, Heck JA, Lin W, Frick DN, Allen TM, Miziorko HM, Schreiber SL, Chung RT) J Infect Dis 2011 Aug 15;204(4):609-16 PMID: 21791663 PMCID: PMC3144167 SCOPUS ID: 2-s2.0-79960851480 07/28/2011       12 Citations
  • Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase. (Mousseau G, Kota S, Takahashi V, Frick DN, Strosberg AD) J Gen Virol 2011 Jan;92(Pt 1):101-11 PMID: 20881089 PMCID: PMC3052529 SCOPUS ID: 2-s2.0-78651249671 10/01/2010       30 Citations
  • PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. (Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA) Antimicrob Agents Chemother 2010 Aug;54(8):3187-96 PMID: 20516278 PMCID: PMC2916354 SCOPUS ID: 2-s2.0-77954646871 06/03/2010       127 Citations
  • Development of novel therapies for hepatitis C. (Lemon SM, McKeating JA, Pietschmann T, Frick DN, Glenn JS, Tellinghuisen TL, Symons J, Furman PA) Antiviral Res 2010 Apr;86(1):79-92 PMID: 20417376 SCOPUS ID: 2-s2.0-77952268322 04/27/2010       73 Citations
  • The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. (Meng X, Zhou Y, Lee EY, Lee MY, Frick DN) Biochemistry 2010 May 04;49(17):3545-54 PMID: 20334433 PMCID: PMC2860660 SCOPUS ID: 2-s2.0-77951690551 03/26/2010       49 Citations
  • A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities. (Frick DN, Ginzburg O, Lam AM) Methods Mol Biol 2010;587:223-33 PMID: 20225153 PMCID: PMC2838209 SCOPUS ID: 2-s2.0-77952976395 03/13/2010       14 Citations
  • Helicase inhibitors as specifically targeted antiviral therapy for hepatitis C. (Belon CA, Frick DN) Future Virol 2009 May 01;4(3):277-293 PMID: 20161209 PMCID: PMC2714653 SCOPUS ID: 2-s2.0-70350102158 02/18/2010       43 Citations
  • Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor. (Belon CA, High YD, Lin TI, Pauwels F, Frick DN) Biochemistry 2010 Mar 09;49(9):1822-32 PMID: 20108979 PMCID: PMC2832472 SCOPUS ID: 2-s2.0-77749289804 01/30/2010       27 Citations
  • Fuel specificity of the hepatitis C virus NS3 helicase. (Belon CA, Frick DN) J Mol Biol 2009 May 15;388(4):851-64 PMID: 19332076 PMCID: PMC2692962 SCOPUS ID: 2-s2.0-67349196370 04/01/2009       18 Citations
  • Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase. (Heck JA, Meng X, Frick DN) Biochem Pharmacol 2009 Apr 01;77(7):1173-80 PMID: 19174155 PMCID: PMC2656422 SCOPUS ID: 2-s2.0-61449166638 01/29/2009       29 Citations
  • DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers. (Meng X, Zhou Y, Zhang S, Lee EY, Frick DN, Lee MY) Nucleic Acids Res 2009 Feb;37(2):647-57 PMID: 19074196 PMCID: PMC2632934 SCOPUS ID: 2-s2.0-59649103417 12/17/2008       74 Citations
  • Monitoring helicase activity with molecular beacons. (Belon CA, Frick DN) Biotechniques 2008 Oct;45(4):433-40, 442 PMID: 18855770 PMCID: PMC2575809 SCOPUS ID: 2-s2.0-55949107966 10/16/2008       54 Citations
  • Effects of mutagenic and chain-terminating nucleotide analogs on enzymes isolated from hepatitis C virus strains of various genotypes. (Heck JA, Lam AM, Narayanan N, Frick DN) Antimicrob Agents Chemother 2008 Jun;52(6):1901-11 PMID: 18391043 PMCID: PMC2415805 SCOPUS ID: 2-s2.0-44449117901 04/09/2008       23 Citations
  • Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level. (Neumann-Haefelin C, Frick DN, Wang JJ, Pybus OG, Salloum S, Narula GS, Eckart A, Biezynski A, Eiermann T, Klenerman P, Viazov S, Roggendorf M, Thimme R, Reiser M, Timm J) J Virol 2008 Apr;82(7):3438-51 PMID: 18216107 PMCID: PMC2268453 SCOPUS ID: 2-s2.0-41149132755 01/25/2008       55 Citations
  • The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target. (Frick DN) Curr Issues Mol Biol 2007 Jan;9(1):1-20 PMID: 17263143 PMCID: PMC3571657 SCOPUS ID: 2-s2.0-33846456636 02/01/2007       122 Citations
  • Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding. (Frick DN, Banik S, Rypma RS) J Mol Biol 2007 Jan 26;365(4):1017-32 PMID: 17084859 PMCID: PMC1829317 SCOPUS ID: 2-s2.0-33845771358 11/07/2006       45 Citations
  • Step-by-step progress toward understanding the hepatitis C virus RNA helicase. (Frick DN) Hepatology 2006 Jun;43(6):1392-5 PMID: 16729317 PMCID: PMC3571624 SCOPUS ID: 2-s2.0-33745582855 05/27/2006       5 Citations
  • Understanding helicases as a means of virus control. (Frick DN, Lam AM) Curr Pharm Des 2006;12(11):1315-38 PMID: 16611118 PMCID: PMC3571686 SCOPUS ID: 2-s2.0-33744980946 04/14/2006       91 Citations
  • Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase. (Lam AM, Frick DN) J Virol 2006 Jan;80(1):404-11 PMID: 16352565 PMCID: PMC1317551 SCOPUS ID: 2-s2.0-33645967464 12/15/2005       112 Citations
  • Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations. (Frick DN, Rypma RS, Lam AM, Frenz CM) Nucleic Acids Res 2004;32(18):5519-28 PMID: 15479787 PMCID: PMC524300 SCOPUS ID: 2-s2.0-6044262451 10/14/2004       31 Citations
  • Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding. (Lam AM, Rypma RS, Frick DN) Nucleic Acids Res 2004;32(13):4060-70 PMID: 15289579 PMCID: PMC506820 SCOPUS ID: 2-s2.0-3242884682 08/04/2004       33 Citations
  • The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently. (Frick DN, Rypma RS, Lam AM, Gu B) J Biol Chem 2004 Jan 09;279(2):1269-80 PMID: 14585830 PMCID: PMC3571687 SCOPUS ID: 2-s2.0-0346463036 10/31/2003       97 Citations
  • Helicases as antiviral drug targets. (Frick DN) Drug News Perspect 2003;16(6):355-62 PMID: 12973446 PMCID: PMC3571683 SCOPUS ID: 2-s2.0-0141758201 09/16/2003       60 Citations
  • Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action. (Lam AM, Keeney D, Frick DN) J Biol Chem 2003 Nov 07;278(45):44514-24 PMID: 12944414 PMCID: PMC3571693 SCOPUS ID: 2-s2.0-0242582359 08/29/2003       54 Citations
  • Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties. (Lam AM, Keeney D, Eckert PQ, Frick DN) J Virol 2003 Apr;77(7):3950-61 PMID: 12634355 PMCID: PMC150621 SCOPUS ID: 2-s2.0-0037377763 03/14/2003       56 Citations
  • DNA primases. (Frick DN, Richardson CC) Annu Rev Biochem 2001;70:39-80 PMID: 11395402 SCOPUS ID: 2-s2.0-0034912668 06/08/2001       312 Citations
  • A complex of the bacteriophage T7 primase-helicase and DNA polymerase directs primer utilization. (Kato M, Frick DN, Lee J, Tabor S, Richardson CC, Ellenberger T) J Biol Chem 2001 Jun 15;276(24):21809-20 PMID: 11279245 SCOPUS ID: 2-s2.0-0035877578 03/30/2001       34 Citations
  • Characterization of a novel DNA primase from the Salmonella typhimurium bacteriophage SP6. (Tseng TY, Frick DN, Richardson CC) Biochemistry 2000 Feb 22;39(7):1643-54 PMID: 10677213 SCOPUS ID: 2-s2.0-0034700987 02/26/2000       12 Citations
  • Interaction of ribonucleoside triphosphates with the gene 4 primase of bacteriophage T7. (Frick DN, Kumar S, Richardson CC) J Biol Chem 1999 Dec 10;274(50):35899-907 PMID: 10585475 SCOPUS ID: 2-s2.0-0033544908 12/10/1999       33 Citations
  • Interaction of bacteriophage T7 gene 4 primase with its template recognition site. (Frick DN, Richardson CC) J Biol Chem 1999 Dec 10;274(50):35889-98 PMID: 10585474 SCOPUS ID: 2-s2.0-0033544950 12/10/1999       51 Citations
  • Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. (Dunn CA, O'Handley SF, Frick DN, Bessman MJ) J Biol Chem 1999 Nov 05;274(45):32318-24 PMID: 10542272 SCOPUS ID: 2-s2.0-0033527537 11/05/1999       137 Citations
  • An N-terminal fragment of the gene 4 helicase/primase of bacteriophage T7 retains primase activity in the absence of helicase activity. (Frick DN, Baradaran K, Richardson CC) Proc Natl Acad Sci U S A 1998 Jul 07;95(14):7957-62 PMID: 9653122 PMCID: PMC20911 SCOPUS ID: 2-s2.0-0032493373 07/08/1998       66 Citations
  • Orf186 represents a new member of the Nudix hydrolases, active on adenosine(5')triphospho(5')adenosine, ADP-ribose, and NADH. (O'Handley SF, Frick DN, Dunn CA, Bessman MJ) J Biol Chem 1998 Feb 06;273(6):3192-7 PMID: 9452430 SCOPUS ID: 2-s2.0-0032488819 03/07/1998       69 Citations
  • Solution structure of the quaternary MutT-M2+-AMPCPP-M2+ complex and mechanism of its pyrophosphohydrolase action. (Lin J, Abeygunawardana C, Frick DN, Bessman MJ, Mildvan AS) Biochemistry 1997 Feb 11;36(6):1199-211 PMID: 9063868 SCOPUS ID: 2-s2.0-0031027111 02/11/1997       82 Citations
  • The MutT proteins or "Nudix" hydrolases, a family of versatile, widely distributed, "housecleaning" enzymes. (Bessman MJ, Frick DN, O'Handley SF) J Biol Chem 1996 Oct 11;271(41):25059-62 PMID: 8810257 SCOPUS ID: 2-s2.0-0029835350 10/11/1996       598 Citations
  • Escherichia coli orf17 codes for a nucleoside triphosphate pyrophosphohydrolase member of the MutT family of proteins. Cloning, purification, and characterization of the enzyme. (O'Handley SF, Frick DN, Bullions LC, Mildvan AS, Bessman MJ) J Biol Chem 1996 Oct 04;271(40):24649-54 PMID: 8798731 SCOPUS ID: 2-s2.0-0029763447 10/04/1996       59 Citations
  • The role of Glu 57 in the mechanism of the Escherichia coli MutT enzyme by mutagenesis and heteronuclear NMR. (Lin J, Abeygunawardana C, Frick DN, Bessman MJ, Mildvan AS) Biochemistry 1996 May 28;35(21):6715-26 PMID: 8639622 SCOPUS ID: 2-s2.0-0029894147 05/28/1996       52 Citations
  • Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase. (Abeygunawardana C, Weber DJ, Gittis AG, Frick DN, Lin J, Miller AF, Bessman MJ, Mildvan AS) Biochemistry 1995 Nov 21;34(46):14997-5005 PMID: 7578113 SCOPUS ID: 2-s2.0-0028972054 11/21/1995       92 Citations
  • A novel GDP-mannose mannosyl hydrolase shares homology with the MutT family of enzymes. (Frick DN, Townsend BD, Bessman MJ) J Biol Chem 1995 Oct 13;270(41):24086-91 PMID: 7592609 SCOPUS ID: 2-s2.0-0028875589 10/13/1995       66 Citations
  • NMR studies of the conformations and location of nucleotides bound to the Escherichia coli MutT enzyme. (Frick DN, Weber DJ, Abeygunawardana C, Gittis AG, Bessman MJ, Mildvan AS) Biochemistry 1995 Apr 25;34(16):5577-86 PMID: 7727419 SCOPUS ID: 2-s2.0-0029024156 04/25/1995       44 Citations
  • Cloning, purification, and properties of a novel NADH pyrophosphatase. Evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes. (Frick DN, Bessman MJ) J Biol Chem 1995 Jan 27;270(4):1529-34 PMID: 7829480 SCOPUS ID: 2-s2.0-0028900818 01/27/1995       89 Citations
  • Dual divalent cation requirement of the MutT dGTPase. Kinetic and magnetic resonance studies of the metal and substrate complexes. (Frick DN, Weber DJ, Gillespie JR, Bessman MJ, Mildvan AS) J Biol Chem 1994 Jan 21;269(3):1794-803 PMID: 8294428 SCOPUS ID: 2-s2.0-0028047580 01/21/1994       54 Citations
  • Sequence-specific assignments of the backbone 1H, 13C, and 15N resonances of the MutT enzyme by heteronuclear multidimensional NMR. (Abeygunawardana C, Weber DJ, Frick DN, Bessman MJ, Mildvan AS) Biochemistry 1993 Dec 07;32(48):13071-80 PMID: 8241161 SCOPUS ID: 2-s2.0-0027744424 12/07/1993       29 Citations
    • Last update: 02/09/2022