Medical College of Wisconsin
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Fumou Sun PhD

Fumou Sun PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Medicine Hematology Oncology

image of /images/ORCIDiD_icon16x16.png   https://orcid.org/0000-0003-2034-3492

Member of the Cancer Center
Member of the Cardiovascular Research Center


I am willing to collaborate on research projects.
I am willing to be a peer mentor.
I am willing to mentor a junior faculty member.

View Curriculum Vitae

Publications (34)

  • Radiation-induced remodeling of the T cell landscape in head and neck cancer. (Memon AA, Said I, Norenberg E, Frei A, Foeckler J, Sun F, Dwinell MB, Lochhead RB, Bruening J, Akakpo K, Massey B, Wong SJ, Hematti P, Kearl TJ, Awan MJ, Himburg HA, Zenga J) Cancer Immunol Immunother 2026 Apr 15;75(5) PMID: 41984232 PMCID: PMC13083680 SCOPUS ID: 2-s2.0-105035819105 04/15/2026    
  • Polyclonal plasma cell (PolyPC) signature as a key indicator for predicting the progression of MGUS to multiple myeloma. (Sun F, Cheng Y, Ma C, Xu H, Bailey C, Mery D, Ashby TC, Alapat D, Li Y, Young KH, Al Hadidi S, Thanendrarajan S, Schinke C, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F) Cancer Biomark 2025 Jun;42(6):18758592251344936 PMID: 40485257 PMCID: PMC12288413 SCOPUS ID: 2-s2.0-105008587424 06/09/2025    
  • Cystatin M/E Ameliorates Multiple Myeloma-Induced Hyper Osteolytic Bone Resorption. (Gai D, Caviness PC, Lazarenko OP, Chen JF, Randolph CE, Zhang Z, Cheng Y, Sun F, Xu H, Blackburn ML, Tricot G, Shaughnessy JD Jr, Chen JR, Zhan F) Cancers (Basel) 2025 Feb 27;17(5) PMID: 40075680 PMCID: PMC11899016 SCOPUS ID: 2-s2.0-86000629000 03/13/2025    
  • Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages. (Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Siegel ER, Xu H, Johnson S, Guo W, Bailey C, Ashby C, Bauer MA, Hadidi SA, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F) Blood Cancer J 2024 Nov 06;14(1):194 PMID: 39505839 PMCID: PMC11541562 SCOPUS ID: 2-s2.0-85208688649 11/07/2024       26 Citations
  • Enhancing prognostic power in multiple myeloma using a plasma cell signature derived from single-cell RNA sequencing. (Li JR, Arsang-Jang S, Cheng Y, Sun F, D'Souza A, Dhakal B, Hari P, Huang Q, Auer P, Li Y, Urrutia R, Zhan F, Shaughnessy JD Jr, Janz S, Dong J, Cheng C) Blood Cancer J 2024 Mar 06;14(1):38 PMID: 38443358 PMCID: PMC10915134 SCOPUS ID: 2-s2.0-85186929795 03/06/2024       6 Citations
  • Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth. (Sun F, Cheng Y, Wanchai V, Guo W, Mery D, Xu H, Gai D, Siegel E, Bailey C, Ashby C, Al Hadidi S, Schinke C, Thanendrarajan S, Ma Y, Yi Q, Orlowski RZ, Zangari M, van Rhee F, Janz S, Bishop G, Tricot G, Shaughnessy JD Jr, Zhan F) Nat Commun 2024 Jan 19;15(1):615 PMID: 38242888 PMCID: PMC10798961 SCOPUS ID: 2-s2.0-85182665152 01/20/2024       35 Citations
  • BCMA- and CST6-specific CAR T cells lyse multiple myeloma cells and suppress murine osteolytic lesions. (Sun F, Cheng Y, Chen JR, Wanchai V, Mery DE, Xu H, Gai D, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F) J Clin Invest 2024 Jan 02;134(1) PMID: 37883186 PMCID: PMC10760955 SCOPUS ID: 2-s2.0-85181494585 10/26/2023       5 Citations
  • High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma. (Cheng Y, Sun F, Alapat DV, Wanchai V, Mery D, Guo W, Cao H, Zhu Y, Ashby C, Bauer MA, Nookaew I, Siegel ER, Ying J, Chen JR, Gai D, Peng B, Xu H, Bailey C, Al Hadidi S, Schinke C, Thanendrarajan S, Zangari M, Chesi M, Bergsagel PL, van Rhee F, Janz S, Tricot G, Shaughnessy JD Jr, Zhan F) Cell Rep Med 2023 Oct 17;4(10):101214 PMID: 37794587 PMCID: PMC10591052 SCOPUS ID: 2-s2.0-85173718596 10/05/2023       14 Citations
  • IL6Myc mouse is an immunocompetent model for the development of aggressive multiple myeloma. (Pisano MD, Sun F, Cheng Y, Parashar D, Zhou V, Jing X, Sompallae R, Abrudan J, Zimmermann MT, Mathison A, Janz S, Pufall MA) Haematologica 2023 Dec 01;108(12):3372-3383 PMID: 37439384 PMCID: PMC10690922 SCOPUS ID: 2-s2.0-85178652041 07/13/2023       2 Citations
  • A gene signature can predict risk of MGUS progressing to multiple myeloma. (Sun F, Cheng Y, Ying J, Mery D, Al Hadidi S, Wanchai V, Siegel ER, Xu H, Gai D, Ashby TC, Bailey C, Chen JR, Schinke C, Thanendrarajan S, Zangari M, Janz S, Barlogie B, Van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F) J Hematol Oncol 2023 Jun 29;16(1):70 PMID: 37386588 PMCID: PMC10308756 SCOPUS ID: 2-s2.0-85163879552 06/30/2023       8 Citations
  • αVEGFR2-MICA fusion antibodies enhance immunotherapy effect and synergize with PD-1 blockade. (Pan M, Wang F, Nan L, Yang S, Qi J, Xie J, Shao S, Zou H, Wang M, Sun F, Zhang J) Cancer Immunol Immunother 2023 Apr;72(4):969-984 PMID: 36227341 PMCID: PMC10991987 SCOPUS ID: 2-s2.0-85139789959 10/14/2022       16 Citations
  • CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation. (Gai D, Chen JR, Stewart JP, Nookaew I, Habelhah H, Ashby C, Sun F, Cheng Y, Li C, Xu H, Peng B, Garg TK, Schinke C, Thanendrarajan S, Zangari M, Chen F, Barlogie B, van Rhee F, Tricot G, Shaughnessy JD Jr, Zhan F) J Clin Invest 2022 Sep 15;132(18) PMID: 35881476 PMCID: PMC9479617 SCOPUS ID: 2-s2.0-85138446467 07/27/2022       24 Citations
  • FOXM1 regulates glycolysis and energy production in multiple myeloma. (Cheng Y, Sun F, Thornton K, Jing X, Dong J, Yun G, Pisano M, Zhan F, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Hari P, Janz S) Oncogene 2022 Aug;41(32):3899-3911 PMID: 35794249 PMCID: PMC9355869 SCOPUS ID: 2-s2.0-85133568311 07/07/2022       45 Citations
  • Baicalin regulates autophagy to interfere with small intestinal acute graft-versus-host disease. (Sun X, Pisano M, Xu L, Sun F, Xu J, Zheng W, Liu X, Zhang Y, Sun R, Cui X) Sci Rep 2022 Apr 21;12(1):6551 PMID: 35449393 PMCID: PMC9023573 SCOPUS ID: 2-s2.0-85128592038 04/23/2022       19 Citations
  • Critical Role for Cap-Independent c-MYC Translation in Progression of Multiple Myeloma. (Shi Y, Sun F, Cheng Y, Holmes B, Dhakal B, Gera JF, Janz S, Lichtenstein A) Mol Cancer Ther 2022 Apr 01;21(4):502-510 PMID: 35086951 PMCID: PMC8983490 SCOPUS ID: 2-s2.0-85128145497 01/29/2022       7 Citations
  • WDR26 and MTF2 are therapeutic targets in multiple myeloma. (Sun F, Cheng Y, Riordan JD, Dupuy A, Dubois W, Pisano M, Dong J, Mock B, Zhan F, Hari P, Janz S) J Hematol Oncol 2021 Dec 07;14(1):203 PMID: 34876184 PMCID: PMC8650373 SCOPUS ID: 2-s2.0-85120899924 12/09/2021       8 Citations
  • Laboratory Mice - A Driving Force in Immunopathology and Immunotherapy Studies of Human Multiple Myeloma. (Pisano M, Cheng Y, Sun F, Dhakal B, D'Souza A, Chhabra S, Knight JM, Rao S, Zhan F, Hari P, Janz S) Front Immunol 2021;12:667054 PMID: 34149703 PMCID: PMC8206561 SCOPUS ID: 2-s2.0-85108140164 06/22/2021       6 Citations
  • Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related peripheral neuropathy. (Zhang Y, Pisano M, Li N, Tan G, Sun F, Cheng Y, Zhang Y, Cui X) Cell Signal 2021 Feb;78:109872 PMID: 33290841 SCOPUS ID: 2-s2.0-85097789278 12/09/2020       22 Citations
  • Autonomic nervous system control of multiple myeloma. (Cheng Y, Sun F, D'Souza A, Dhakal B, Pisano M, Chhabra S, Stolley M, Hari P, Janz S) Blood Rev 2021 Mar;46:100741 PMID: 32807576 PMCID: PMC7876165 SCOPUS ID: 2-s2.0-85089534779 08/19/2020       20 Citations
  • HPA aptamer functionalized paclitaxel-loaded PLGA nanoparticles for enhanced anticancer therapy through targeted effects and microenvironment modulation. (Duan T, Xu Z, Sun F, Wang Y, Zhang J, Luo C, Wang M) Biomed Pharmacother 2019 Sep;117:109121 PMID: 31252265 SCOPUS ID: 2-s2.0-85067820191 06/30/2019       63 Citations
  • Osteolytic disease in IL-6 and Myc dependent mouse model of human myeloma. (Sun F, Cheng Y, Walsh SA, Acevedo MR, Jing X, Han SS, Pisano MD, Tomasson MH, Lichtenstein AK, Zhan F, Hari P, Janz S) Haematologica 2020 Mar;105(3):e111-e115 PMID: 31221780 PMCID: PMC7049347 SCOPUS ID: 2-s2.0-85080963194 06/22/2019       5 Citations
  • Germline Risk Contribution to Genomic Instability in Multiple Myeloma. (Janz S, Zhan F, Sun F, Cheng Y, Pisano M, Yang Y, Goldschmidt H, Hari P) Front Genet 2019;10:424 PMID: 31139207 PMCID: PMC6518313 SCOPUS ID: 2-s2.0-85067859695 05/30/2019       22 Citations
  • Anti-CD24 Antibody-Nitric Oxide Conjugate Selectively and Potently Suppresses Hepatic Carcinoma. (Sun F, Wang Y, Luo X, Ma Z, Xu Y, Zhang X, Lv T, Zhang Y, Wang M, Huang Z, Zhang J) Cancer Res 2019 Jul 01;79(13):3395-3405 PMID: 30918001 SCOPUS ID: 2-s2.0-85068833887 03/29/2019       58 Citations
  • CD24 targeting bi-specific antibody that simultaneously stimulates NKG2D enhances the efficacy of cancer immunotherapy. (Han Y, Sun F, Zhang X, Wang T, Jiang J, Cai J, Gao Q, Hezam K, Liu Y, Xie J, Wang M, Zhang J) J Cancer Res Clin Oncol 2019 May;145(5):1179-1190 PMID: 30778749 PMCID: PMC11810302 SCOPUS ID: 2-s2.0-85061712794 02/20/2019       41 Citations
  • NKG2D Immunoligand rG7S-MICA Enhances NK Cell-mediated Immunosurveillance in Colorectal Carcinoma. (Wang T, Sun F, Wang Y, Jiang J, Pan M, Yuan M, Zhang H, Du X, Hezam K, Song K, Wang M, Zhang J) J Immunother 2018 Apr;41(3):109-117 PMID: 29528990 SCOPUS ID: 2-s2.0-85044348477 03/13/2018       16 Citations
  • Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells. (Hezam K, Jiang J, Sun F, Zhang X, Zhang J) Rev Neurosci 2018 Jan 26;29(1):93-98 PMID: 28937965 SCOPUS ID: 2-s2.0-85037694231 09/25/2017       21 Citations
  • The two novel DLL4-targeting antibody-drug conjugates MvM03 and MGD03 show potent anti-tumour activity in breast cancer xenograft models. (Wang S, Zhou R, Sun F, Li R, Wang M, Wu M) Cancer Lett 2017 Nov 28;409:125-136 PMID: 28923397 SCOPUS ID: 2-s2.0-85030263579 09/20/2017       12 Citations
  • Engineering a high-affinity humanized anti-CD24 antibody to target hepatocellular carcinoma by a novel CDR grafting design. (Sun F, Wang T, Jiang J, Wang Y, Ma Z, Li Z, Han Y, Pan M, Cai J, Wang M, Zhang J) Oncotarget 2017 Aug 01;8(31):51238-51252 PMID: 28881644 PMCID: PMC5584245 SCOPUS ID: 2-s2.0-85026746567 09/09/2017       32 Citations
  • Selective targeted delivery of doxorubicin via conjugating to anti-CD24 antibody results in enhanced antitumor potency for hepatocellular carcinoma both in vitro and in vivo. (Ma Z, He H, Sun F, Xu Y, Huang X, Ma Y, Zhao H, Wang Y, Wang M, Zhang J) J Cancer Res Clin Oncol 2017 Oct;143(10):1929-1940 PMID: 28536738 PMCID: PMC11819455 SCOPUS ID: 2-s2.0-85019886990 05/26/2017       33 Citations
  • Anti-VEGFR2-interferon-α2 regulates the tumor microenvironment and exhibits potent antitumor efficacy against colorectal cancer. (Li Z, Zhu Y, Li C, Trinh R, Ren X, Sun F, Wang Y, Shang P, Wang T, Wang M, Morrison SL, Zhang J) Oncoimmunology 2017;6(3):e1290038 PMID: 28405526 PMCID: PMC5384376 SCOPUS ID: 2-s2.0-85016598365 04/14/2017       25 Citations
  • VEGFR2 targeted antibody fused with MICA stimulates NKG2D mediated immunosurveillance and exhibits potent anti-tumor activity against breast cancer. (Xie W, Liu F, Wang Y, Ren X, Wang T, Chen Z, Tang M, Sun F, Li Z, Wang M, Zhang J) Oncotarget 2016 Mar 29;7(13):16445-61 PMID: 26909862 PMCID: PMC4941327 SCOPUS ID: 2-s2.0-84971667827 02/26/2016       21 Citations
  • A bispecific protein rG7S-MICA recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma. (Wang T, Sun F, Xie W, Tang M, He H, Jia X, Tian X, Wang M, Zhang J) Cancer Lett 2016 Mar 28;372(2):166-78 PMID: 26791237 SCOPUS ID: 2-s2.0-84957627273 01/23/2016       48 Citations
  • Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway. (Gong J, Sun F, Li Y, Zhou X, Duan Z, Duan F, Zhao L, Chen H, Qi S, Shen J) Neuropharmacology 2015 Apr;91:123-34 PMID: 25510970 SCOPUS ID: 2-s2.0-84921047013 12/17/2014       97 Citations
  • Neuroprotection of paclitaxel against cerebral ischemia/reperfusion-induced brain injury through JNK3 signaling pathway. (Qi SH, Zhao H, Gong JJ, Sun FM, Yue J, Guan QH, Wang M) J Recept Signal Transduct Res 2011 Dec;31(6):402-7 PMID: 22060185 SCOPUS ID: 2-s2.0-80955142406 11/09/2011       8 Citations
    • Last update: 05/14/2026