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Madhusudan Dey PhD
Assistant Professor
Institution:
University of Wisconsin - Milwaukee
Department:
Biological Sciences
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Publications (12)
Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop.
(Dey M, Mann BR, Anshu A, Mannan MA)
J Biol Chem
2014 Feb 28;289(9):5747-57 PMID: 24338483 PMCID: PMC3937647 SCOPUS ID: 2-s2.0-84896808986 12/18/2013
45 Citations
An ire1-phk1 chimera reveals a dispensable role of autokinase activity in endoplasmic reticulum stress response.
(Mannan MA, Shadrick WR, Biener G, Shin BS, Anshu A, Raicu V, Frick DN, Dey M)
J Mol Biol
2013 Jun 26;425(12):2083-99 PMID: 23541589 SCOPUS ID: 2-s2.0-84878233437 04/02/2013
16 Citations
Requirement for kinase-induced conformational change in eukaryotic initiation factor 2alpha (eIF2alpha) restricts phosphorylation of Ser51.
(Dey M, Velyvis A, Li JJ, Chiu E, Chiovitti D, Kay LE, Sicheri F, Dever TE)
Proc Natl Acad Sci U S A
2011 Mar 15;108(11):4316-21 PMID: 21368187 PMCID: PMC3060252 SCOPUS ID: 2-s2.0-79952727150 03/04/2011
19 Citations
Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.
(Dev K, Santangelo TJ, Rothenburg S, Neculai D, Dey M, Sicheri F, Dever TE, Reeve JN, Hinnebusch AG)
J Mol Biol
2009 Sep 25;392(3):701-22 PMID: 19616556 PMCID: PMC2937263 SCOPUS ID: 2-s2.0-69349100057 07/21/2009
27 Citations
A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.
(Gárriz A, Qiu H, Dey M, Seo EJ, Dever TE, Hinnebusch AG)
Mol Cell Biol
2009 Mar;29(6):1592-607 PMID: 19114556 PMCID: PMC2648240 SCOPUS ID: 2-s2.0-62849097490 12/31/2008
27 Citations
Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplications.
(Rothenburg S, Deigendesch N, Dey M, Dever TE, Tazi L)
BMC Biol
2008 Mar 03;6:12 PMID: 18312693 PMCID: PMC2291453 SCOPUS ID: 2-s2.0-41949115912 03/04/2008
68 Citations
Structure of the dual enzyme Ire1 reveals the basis for catalysis and regulation in nonconventional RNA splicing.
(Lee KP, Dey M, Neculai D, Cao C, Dever TE, Sicheri F)
Cell
2008 Jan 11;132(1):89-100 PMID: 18191223 PMCID: PMC2276645 SCOPUS ID: 2-s2.0-37649004940 01/15/2008
296 Citations
Novel membrane-bound eIF2alpha kinase in the flagellar pocket of Trypanosoma brucei.
(Moraes MC, Jesus TC, Hashimoto NN, Dey M, Schwartz KJ, Alves VS, Avila CC, Bangs JD, Dever TE, Schenkman S, Castilho BA)
Eukaryot Cell
2007 Nov;6(11):1979-91 PMID: 17873083 PMCID: PMC2168417 SCOPUS ID: 2-s2.0-36849092889 09/18/2007
57 Citations
Conserved intermolecular salt bridge required for activation of protein kinases PKR, GCN2, and PERK.
(Dey M, Cao C, Sicheri F, Dever TE)
J Biol Chem
2007 Mar 02;282(9):6653-60 PMID: 17202131 SCOPUS ID: 2-s2.0-34250354002 01/05/2007
48 Citations
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.
(Dey M, Cao C, Dar AC, Tamura T, Ozato K, Sicheri F, Dever TE)
Cell
2005 Sep 23;122(6):901-13 PMID: 16179259 SCOPUS ID: 2-s2.0-25144477805 09/24/2005
293 Citations
PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha.
(Dey M, Trieselmann B, Locke EG, Lu J, Cao C, Dar AC, Krishnamoorthy T, Dong J, Sicheri F, Dever TE)
Mol Cell Biol
2005 Apr;25(8):3063-75 PMID: 15798194 PMCID: PMC1069625 SCOPUS ID: 2-s2.0-20144386673 03/31/2005
59 Citations
Evidence of two forms of poly(A) polymerase in germinated wheat embryos and their regulation by a novel protein kinase.
(Sharma N, Dey M, Satpathy M, Sachar RC)
Biochem Biophys Res Commun
2002 Apr 26;293(1):403-11 PMID: 12054614 SCOPUS ID: 2-s2.0-0036290793 06/11/2002
Last update: 01/31/2014