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Matt Durand PhD

Matt Durand PhD profile photo picture

Associate Professor

Institution: Medical College of Wisconsin
Department: Physical Medicine and Rehabilitation
Program: Adult

Member of the Cancer Center
Member of the Cardiovascular Center
Member of the Neuroscience Research Center


Research Experience

  • Angiotensin II
  • Endothelium-Dependent Relaxing Factors
  • Exercise
  • Exercise Therapy
  • Frailty
  • Hypertension
  • Ischemic Postconditioning
  • Ischemic Preconditioning
  • Mitochondria
  • Nitric Oxide
  • Stroke
  • Stroke Rehabilitation
  • Vasodilation
  • Prehabilitation
  • Leadership Positions

  • Research Director - Department of Physical Medicine and Rehabilitation
  • MCW Program / Core Facilities

  • Cardiovascular Center
  • Publications (28)

  • Identifying High-Attenuating and Low-Attenuating Muscle Using Computerized Tomography and Exploring Its Impact on Physical Function and Muscle Strength in Obese Critically Ill Patients. (Patel JJ, Baruah D, Sobush D, Koester K, Aase J, Zellner S, Graf J, Durand MJ, Szabo A, Shahir K) Nutr Clin Pract 2020 Feb;35(1):133-141 PMID: 31172570 SCOPUS ID: 2-s2.0-85067355654 06/07/2019       1 Citation
  • The Relationship Between Blood Flow and Motor Unit Firing Rates in Response to Fatiguing Exercise Post-stroke. (Murphy S, Durand M, Negro F, Farina D, Hunter S, Schmit B, Gutterman D, Hyngstrom A) Front Physiol 2019;10:545 PMID: 31133877 PMCID: PMC6524339 05/28/2019    
  • Two weeks of ischemic conditioning improves walking speed and reduces neuromuscular fatigability in chronic stroke survivors. (Durand MJ, Boerger TF, Nguyen JN, Alqahtani SZ, Wright MT, Schmit BD, Gutterman DD, Hyngstrom AS) J Appl Physiol (1985) 2019 03 01;126(3):755-763 PMID: 30653420 PMCID: PMC6459385 01/18/2019       5 Citations
  • Visualization and quantification of mitochondrial structure in the endothelium of intact arteries. (Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM) Cardiovasc Res 2019 08 01;115(10):1546-1556 PMID: 30476208 PMCID: PMC6648341 SCOPUS ID: 2-s2.0-85072658081 11/27/2018       2 Citations
  • Ischemic conditioning increases strength and volitional activation of paretic muscle in chronic stroke: a pilot study. (Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ) J Appl Physiol (1985) 2018 05 01;124(5):1140-1147 PMID: 29420152 PMCID: PMC6050199 02/09/2018       12 Citations
  • Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha. (Kadlec AO, Barnes C, Durand MJ, Gutterman DD) Am J Hypertens 2018 01 12;31(2):240-246 PMID: 29140431 PMCID: PMC5861535 11/16/2017       6 Citations
  • PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure. (Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD) Hypertension 2017 07;70(1):166-173 PMID: 28533333 PMCID: PMC5485836 SCOPUS ID: 2-s2.0-85019610110 05/24/2017       20 Citations
  • Regenerative Angiogenesis: Quality Over Quantity. (Durand MJ, Ait-Aissa K, Gutterman DD) Circ Res 2017 04 28;120(9):1379-1380 PMID: 28450357 04/30/2017       2 Citations
  • Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. (Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD) Am J Physiol Heart Circ Physiol 2017 May 01;312(5):H1096-H1104 PMID: 28213406 PMCID: PMC5451582 SCOPUS ID: 2-s2.0-85019633788 02/19/2017       10 Citations
  • Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes. (Buchanan CE, Kadlec AO, Hoch AZ, Gutterman DD, Durand MJ) Med Sci Sports Exerc 2017 04;49(4):669-675 PMID: 27824690 PMCID: PMC5357152 11/09/2016       7 Citations
  • Does Barostress On The Endothelium During Maximal Exertion Cause Endothelial Dysfunction In Healthy, Sedentary Subjects?: 707 Board #23 June 1, 3: 30 PM - 5: 00 PM. (Durand MJ, Buchanan CE, Hoch AZ, Gutterman DD) Med Sci Sports Exerc 2016 May;48(5 Suppl 1):189-90 PMID: 27359850 07/01/2016    
  • Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. (Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM) Arterioscler Thromb Vasc Biol 2016 06;36(6):1254-62 PMID: 27079876 PMCID: PMC4882242 SCOPUS ID: 2-s2.0-84963556451 04/16/2016       25 Citations
  • The Human Microcirculation: Regulation of Flow and Beyond. (Gutterman DD, Chabowski DS, Kadlec AO, Durand MJ, Freed JK, Ait-Aissa K, Beyer AM) Circ Res 2016 Jan 08;118(1):157-72 PMID: 26837746 PMCID: PMC4742348 SCOPUS ID: 2-s2.0-84954534623 02/04/2016       102 Citations
  • The Human Microcirculation Regulation of Flow and Beyond (David D. Gutterman, Dawid S. Chabowski, Andrew O. Kadlec, Matthew J. Durand, Julie K. Freed, Karima Ait-Aissa, Andreas M. Beyer) Circ Res 01/08/2016    
  • Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. (Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD) Circ Res 2016 Mar 04;118(5):856-66 PMID: 26699654 PMCID: PMC4772813 SCOPUS ID: 2-s2.0-84952008563 12/25/2015       49 Citations
  • Impaired Hyperemic Response to Exercise Post Stroke. (Durand MJ, Murphy SA, Schaefer KK, Hunter SK, Schmit BD, Gutterman DD, Hyngstrom AS) PLoS One 2015;10(12):e0144023 PMID: 26630380 PMCID: PMC4667998 12/03/2015       6 Citations
  • Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. (Durand MJ, Dharmashankar K, Bian JT, Das E, Vidovich M, Gutterman DD, Phillips SA) Hypertension 2015 Jan;65(1):140-5 PMID: 25368025 PMCID: PMC4268168 11/05/2014       39 Citations
  • An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. (Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Dec 01;307(11):H1587-93 PMID: 25260615 PMCID: PMC4255007 SCOPUS ID: 2-s2.0-84913573408 09/28/2014       41 Citations
  • Exercise and vascular function: how much is too much? (Durand MJ, Gutterman DD) Can J Physiol Pharmacol 2014 Jul;92(7):551-7 PMID: 24873760 PMCID: PMC4398063 05/31/2014       21 Citations
  • The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. (Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Jul 01;307(1):H25-32 PMID: 24778165 PMCID: PMC4080172 SCOPUS ID: 2-s2.0-84903587126 04/30/2014       14 Citations
  • Vascular dysfunction in diabetes mellitus: large conductance calcium-activated potassium channels as part of a subsarcolemmal signaling soiree. (Gutterman DD, Durand MJ) Circ Res 2014 Feb 14;114(4):588-90 PMID: 24526670 02/15/2014       3 Citations
  • Low-dose angiotensin II infusion restores vascular function in cerebral arteries of high salt-fed rats by increasing copper/zinc superoxide dimutase expression. (Durand MJ, Lombard JH) Am J Hypertens 2013 Jun;26(6):739-47 PMID: 23443725 PMCID: PMC3697069 SCOPUS ID: 2-s2.0-84877785615 02/28/2013       23 Citations
  • Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. (Durand MJ, Gutterman DD) Microcirculation 2013 Apr;20(3):239-47 PMID: 23311975 PMCID: PMC3625248 01/15/2013       91 Citations
  • Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats. (Raffai G, Durand MJ, Lombard JH) Am J Physiol Heart Circ Physiol 2011 Oct;301(4):H1341-52 PMID: 21803946 PMCID: PMC3197355 SCOPUS ID: 2-s2.0-80053276066 08/02/2011       43 Citations
  • Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries. (Durand MJ, Lombard JH) Am J Hypertens 2011 May;24(5):563-8 PMID: 21331057 PMCID: PMC3285562 SCOPUS ID: 2-s2.0-79954754567 02/19/2011       13 Citations
  • Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene. (Durand MJ, Moreno C, Greene AS, Lombard JH) Am J Physiol Heart Circ Physiol 2010 Dec;299(6):H1865-74 PMID: 20852041 PMCID: PMC3006280 SCOPUS ID: 2-s2.0-78649747016 09/21/2010       17 Citations
  • Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries. (Durand MJ, Raffai G, Weinberg BD, Lombard JH) Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1024-33 PMID: 20656887 PMCID: PMC2957344 SCOPUS ID: 2-s2.0-77958035132 07/27/2010       40 Citations
  • Angiotensin II maintains cerebral vascular relaxation via EGF receptor transactivation and ERK1/2. (McEwen ST, Balus SF, Durand MJ, Lombard JH) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1296-303 PMID: 19684181 PMCID: PMC2770770 SCOPUS ID: 2-s2.0-70349631795 08/18/2009       16 Citations
  • Last update: 05/04/2020
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