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Nathan A. Truchan PhD
Research Scientist I
Institution:
Medical College of Wisconsin
Department:
Pediatrics
Division:
Endocrinology
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Publications (11)
Monocytes in type 1 diabetes families exhibit high cytolytic activity and subset abundances that correlate with clinical progression.
(Pant T, Lin CW, Bedrat A, Jia S, Roethle MF, Truchan NA, Ciecko AE, Chen YG, Hessner MJ)
Sci Adv
2024 May 17;10(20):eadn2136 PMID: 38758799 PMCID: PMC11100571 SCOPUS ID: 2-s2.0-85193631768 05/17/2024
3 Citations
Albumin nanoparticle containing a PI3Kγ inhibitor and paclitaxel in combination with α-PD1 induces tumor remission of breast cancer in mice.
(Song Y, Bugada L, Li R, Hu H, Zhang L, Li C, Yuan H, Rajanayake KK, Truchan NA, Wen F, Gao W, Sun D)
Sci Transl Med
2022 May 04;14(643):eabl3649 PMID: 35507675 PMCID: PMC9589917 SCOPUS ID: 2-s2.0-85129406215 05/05/2022
63 Citations
Human Islet Expression Levels of Prostaglandin E
2
Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity.
(Truchan NA, Fenske RJ, Sandhu HK, Weeks AM, Patibandla C, Wancewicz B, Pabich S, Reuter A, Harrington JM, Brill AL, Peter DC, Nall R, Daniels M, Punt M, Kaiser CE, Cox ED, Ge Y, Davis DB, Kimple ME)
ACS Pharmacol Transl Sci
2021 Aug 13;4(4):1338-1348 PMID: 34423270 PMCID: PMC8369690 SCOPUS ID: 2-s2.0-85110101691 08/24/2021
10 Citations
The Inhibitory G Protein α-Subunit, Gαz, Promotes Type 1 Diabetes-Like Pathophysiology in NOD Mice.
(Fenske RJ, Cadena MT, Harenda QE, Wienkes HN, Carbajal K, Schaid MD, Laundre E, Brill AL, Truchan NA, Brar H, Wisinski J, Cai J, Graham TE, Engin F, Kimple ME)
Endocrinology
2017 Jun 01;158(6):1645-1658 PMID: 28419211 PMCID: PMC5460933 SCOPUS ID: 2-s2.0-85020220292 04/19/2017
18 Citations
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.
(Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ)
Diabetes
2016 Sep;65(9):2700-10 PMID: 27284112 PMCID: PMC5001174 SCOPUS ID: 2-s2.0-84987608759 06/11/2016
57 Citations
A single-islet microplate assay to measure mouse and human islet insulin secretion.
(Truchan NA, Brar HK, Gallagher SJ, Neuman JC, Kimple ME)
Islets
2015;7(3):e1076607 PMID: 26452321 PMCID: PMC4708880 SCOPUS ID: 2-s2.0-84964066497 10/11/2015
26 Citations
A method for mouse pancreatic islet isolation and intracellular cAMP determination.
(Neuman JC, Truchan NA, Joseph JW, Kimple ME)
J Vis Exp
2014 Jun 25(88):e50374 PMID: 24998772 PMCID: PMC4205887 SCOPUS ID: 2-s2.0-84903384870 07/08/2014
47 Citations
Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line.
(Krautkramer KA, Linnemann AK, Fontaine DA, Whillock AL, Harris TW, Schleis GJ, Truchan NA, Marty-Santos L, Lavine JA, Cleaver O, Kimple ME, Davis DB)
Am J Physiol Endocrinol Metab
2013 Sep 01;305(5):E600-10 PMID: 23860123 PMCID: PMC3761170 SCOPUS ID: 2-s2.0-84883759372 07/19/2013
29 Citations
Prostaglandin E2 receptor, EP3, is induced in diabetic islets and negatively regulates glucose- and hormone-stimulated insulin secretion.
(Kimple ME, Keller MP, Rabaglia MR, Pasker RL, Neuman JC, Truchan NA, Brar HK, Attie AD)
Diabetes
2013 Jun;62(6):1904-12 PMID: 23349487 PMCID: PMC3661627 SCOPUS ID: 2-s2.0-84878231693 01/26/2013
96 Citations
Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass.
(Kimple ME, Moss JB, Brar HK, Rosa TC, Truchan NA, Pasker RL, Newgard CB, Casey PJ)
J Biol Chem
2012 Jun 08;287(24):20344-55 PMID: 22457354 PMCID: PMC3370216 SCOPUS ID: 2-s2.0-84862006012 03/30/2012
32 Citations
Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.
(Bhatnagar S, Oler AT, Rabaglia ME, Stapleton DS, Schueler KL, Truchan NA, Worzella SL, Stoehr JP, Clee SM, Yandell BS, Keller MP, Thurmond DC, Attie AD)
PLoS Genet
2011 Oct;7(10):e1002323 PMID: 21998599 PMCID: PMC3188574 SCOPUS ID: 2-s2.0-80055076208 10/15/2011
60 Citations
Last update: 05/20/2024