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Sarah L. Wynia Smith
Research Scientist II
Institution:
Medical College of Wisconsin
Department:
Biochemistry
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Publications (17)
Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains.
(Olp MD, Bursch KL, Wynia-Smith SL, Nuñez R, Goetz CJ, Jackson V, Smith BC)
J Biol Chem
2025 Mar;301(3):108289 PMID: 39938804 PMCID: PMC11930079 SCOPUS ID: 2-s2.0-85219493438 02/13/2025
The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation.
(Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC)
ACS Chem Biol
2024 Dec 20;19(12):2418-2428 PMID: 39556662 PMCID: PMC11706526 SCOPUS ID: 2-s2.0-85209707761 11/18/2024
2 Citations
Inhibition of Sirtuin Deacylase Activity by Peroxynitrite.
(Bohl K, Wynia-Smith SL, Jones Lipinski RA, Smith BC)
Biochemistry
2024 Oct 01;63(19):2463-2476 PMID: 39256054 PMCID: PMC11524680 SCOPUS ID: 2-s2.0-85205075999 09/11/2024
3 Citations
Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types.
(Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC)
Am J Physiol Regul Integr Comp Physiol
2024 Jun 01;326(6):R515-R527 PMID: 38618911 PMCID: PMC11381023 SCOPUS ID: 2-s2.0-85194976711 04/15/2024
1 Citation
Identification of Protein Targets of
S
-Nitroso-Coenzyme A-Mediated
S
-Nitrosation Using Chemoproteomics.
(Falco JA, Wynia-Smith SL, McCoy J, Smith BC, Weerapana E)
ACS Chem Biol
2024 Jan 19;19(1):193-207 PMID: 38159293 PMCID: PMC11154738 SCOPUS ID: 2-s2.0-85181803360 01/02/2024
1 Citation
N-
terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells.
(Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC)
Front Endocrinol (Lausanne)
2022;13:923925 PMID: 36176467 PMCID: PMC9513428 SCOPUS ID: 2-s2.0-85138892468 10/01/2022
9 Citations
Sirtuin Oxidative Post-translational Modifications.
(Kalous KS, Wynia-Smith SL, Smith BC)
Front Physiol
2021;12:763417 PMID: 34899389 PMCID: PMC8652059 SCOPUS ID: 2-s2.0-85120877526 12/14/2021
15 Citations
Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia.
(Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC)
Blood Adv
2020 Sep 22;4(18):4494-4507 PMID: 32946569 PMCID: PMC7509873 SCOPUS ID: 2-s2.0-85092260584 09/19/2020
25 Citations
Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants.
(Kalous KS, Wynia-Smith SL, Summers SB, Smith BC)
J Biol Chem
2020 Jun 19;295(25):8524-8536 PMID: 32371394 PMCID: PMC7307208 SCOPUS ID: 2-s2.0-85086777279 05/07/2020
20 Citations
Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites.
(Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC)
ACS Chem Biol
2020 Apr 17;15(4):1036-1049 PMID: 32149490 PMCID: PMC7271629 SCOPUS ID: 2-s2.0-85083621949 03/10/2020
39 Citations
Comparative and integrative metabolomics reveal that
S
-nitrosation inhibits physiologically relevant metabolic enzymes.
(Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA)
J Biol Chem
2018 Apr 27;293(17):6282-6296 PMID: 29483187 PMCID: PMC5925818 SCOPUS ID: 2-s2.0-85046036655 02/28/2018
17 Citations
Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.
(Kalous KS, Wynia-Smith SL, Olp MD, Smith BC)
J Biol Chem
2016 Dec 02;291(49):25398-25410 PMID: 27756843 PMCID: PMC5207242 SCOPUS ID: 2-s2.0-85001969732 10/21/2016
45 Citations
Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases.
(Wynia-Smith SL, Smith BC)
Nitric Oxide
2017 Feb 28;63:52-60 PMID: 27720836 SCOPUS ID: 2-s2.0-85002112699 10/11/2016
53 Citations
Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2.
(Zhou Y, Wynia-Smith SL, Couvertier SM, Kalous KS, Marletta MA, Smith BC, Weerapana E)
Cell Chem Biol
2016 Jun 23;23(6):727-37 PMID: 27291402 PMCID: PMC4920707 SCOPUS ID: 2-s2.0-84976439988 06/14/2016
39 Citations
Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia.
(Shteyer E, Edvardson S, Wynia-Smith SL, Pierri CL, Zangen T, Hashavya S, Begin M, Yaacov B, Cinamon Y, Koplewitz BZ, Vromen A, Elpeleg O, Smith BC)
Gastroenterology
2015 Mar;148(3):533-536.e4 PMID: 25479138 SCOPUS ID: 2-s2.0-84924061735 12/06/2014
37 Citations
Electrostatic ratchet in the protective antigen channel promotes anthrax toxin translocation.
(Wynia-Smith SL, Brown MJ, Chirichella G, Kemalyan G, Krantz BA)
J Biol Chem
2012 Dec 21;287(52):43753-64 PMID: 23115233 PMCID: PMC3527960 SCOPUS ID: 2-s2.0-84871545524 11/02/2012
31 Citations
hERG gating microdomains defined by S6 mutagenesis and molecular modeling.
(Wynia-Smith SL, Gillian-Daniel AL, Satyshur KA, Robertson GA)
J Gen Physiol
2008 Nov;132(5):507-20 PMID: 18955593 PMCID: PMC2571969 SCOPUS ID: 2-s2.0-59449096598 10/29/2008
43 Citations
Last update: 04/16/2025