Medical College of Wisconsin
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Sarah L. Wynia Smith

Research Scientist II

Institution: Medical College of Wisconsin
Department: Biochemistry

Publications (17)

  • Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains. (Olp MD, Bursch KL, Wynia-Smith SL, Nuñez R, Goetz CJ, Jackson V, Smith BC) J Biol Chem 2025 Mar;301(3):108289 PMID: 39938804 PMCID: PMC11930079 SCOPUS ID: 2-s2.0-85219493438 02/13/2025    
  • The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation. (Nuñez R, Sidlowski PFW, Steen EA, Wynia-Smith SL, Sprague DJ, Keyes RF, Smith BC) ACS Chem Biol 2024 Dec 20;19(12):2418-2428 PMID: 39556662 PMCID: PMC11706526 SCOPUS ID: 2-s2.0-85209707761 11/18/2024       2 Citations
  • Inhibition of Sirtuin Deacylase Activity by Peroxynitrite. (Bohl K, Wynia-Smith SL, Jones Lipinski RA, Smith BC) Biochemistry 2024 Oct 01;63(19):2463-2476 PMID: 39256054 PMCID: PMC11524680 SCOPUS ID: 2-s2.0-85205075999 09/11/2024       3 Citations
  • Zinc-chelating BET bromodomain inhibitors equally target islet endocrine cell types. (Jones Lipinski RA, Stancill JS, Nuñez R, Wynia-Smith SL, Sprague DJ, Nord JA, Bird A, Corbett JA, Smith BC) Am J Physiol Regul Integr Comp Physiol 2024 Jun 01;326(6):R515-R527 PMID: 38618911 PMCID: PMC11381023 SCOPUS ID: 2-s2.0-85194976711 04/15/2024       1 Citation
  • Identification of Protein Targets of S-Nitroso-Coenzyme A-Mediated S-Nitrosation Using Chemoproteomics. (Falco JA, Wynia-Smith SL, McCoy J, Smith BC, Weerapana E) ACS Chem Biol 2024 Jan 19;19(1):193-207 PMID: 38159293 PMCID: PMC11154738 SCOPUS ID: 2-s2.0-85181803360 01/02/2024       1 Citation
  • N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells. (Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC) Front Endocrinol (Lausanne) 2022;13:923925 PMID: 36176467 PMCID: PMC9513428 SCOPUS ID: 2-s2.0-85138892468 10/01/2022       9 Citations
  • Sirtuin Oxidative Post-translational Modifications. (Kalous KS, Wynia-Smith SL, Smith BC) Front Physiol 2021;12:763417 PMID: 34899389 PMCID: PMC8652059 SCOPUS ID: 2-s2.0-85120877526 12/14/2021       15 Citations
  • Cysteine sulfenylation by CD36 signaling promotes arterial thrombosis in dyslipidemia. (Yang M, Li W, Harberg C, Chen W, Yue H, Ferreira RB, Wynia-Smith SL, Carroll KS, Zielonka J, Flaumenhaft R, Silverstein RL, Smith BC) Blood Adv 2020 Sep 22;4(18):4494-4507 PMID: 32946569 PMCID: PMC7509873 SCOPUS ID: 2-s2.0-85092260584 09/19/2020       25 Citations
  • Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants. (Kalous KS, Wynia-Smith SL, Summers SB, Smith BC) J Biol Chem 2020 Jun 19;295(25):8524-8536 PMID: 32371394 PMCID: PMC7307208 SCOPUS ID: 2-s2.0-85086777279 05/07/2020       20 Citations
  • Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. (Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC) ACS Chem Biol 2020 Apr 17;15(4):1036-1049 PMID: 32149490 PMCID: PMC7271629 SCOPUS ID: 2-s2.0-85083621949 03/10/2020       39 Citations
  • Comparative and integrative metabolomics reveal that S-nitrosation inhibits physiologically relevant metabolic enzymes. (Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA) J Biol Chem 2018 Apr 27;293(17):6282-6296 PMID: 29483187 PMCID: PMC5925818 SCOPUS ID: 2-s2.0-85046036655 02/28/2018       17 Citations
  • Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation. (Kalous KS, Wynia-Smith SL, Olp MD, Smith BC) J Biol Chem 2016 Dec 02;291(49):25398-25410 PMID: 27756843 PMCID: PMC5207242 SCOPUS ID: 2-s2.0-85001969732 10/21/2016       45 Citations
  • Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases. (Wynia-Smith SL, Smith BC) Nitric Oxide 2017 Feb 28;63:52-60 PMID: 27720836 SCOPUS ID: 2-s2.0-85002112699 10/11/2016       53 Citations
  • Chemoproteomic Strategy to Quantitatively Monitor Transnitrosation Uncovers Functionally Relevant S-Nitrosation Sites on Cathepsin D and HADH2. (Zhou Y, Wynia-Smith SL, Couvertier SM, Kalous KS, Marletta MA, Smith BC, Weerapana E) Cell Chem Biol 2016 Jun 23;23(6):727-37 PMID: 27291402 PMCID: PMC4920707 SCOPUS ID: 2-s2.0-84976439988 06/14/2016       39 Citations
  • Truncating mutation in the nitric oxide synthase 1 gene is associated with infantile achalasia. (Shteyer E, Edvardson S, Wynia-Smith SL, Pierri CL, Zangen T, Hashavya S, Begin M, Yaacov B, Cinamon Y, Koplewitz BZ, Vromen A, Elpeleg O, Smith BC) Gastroenterology 2015 Mar;148(3):533-536.e4 PMID: 25479138 SCOPUS ID: 2-s2.0-84924061735 12/06/2014       37 Citations
  • Electrostatic ratchet in the protective antigen channel promotes anthrax toxin translocation. (Wynia-Smith SL, Brown MJ, Chirichella G, Kemalyan G, Krantz BA) J Biol Chem 2012 Dec 21;287(52):43753-64 PMID: 23115233 PMCID: PMC3527960 SCOPUS ID: 2-s2.0-84871545524 11/02/2012       31 Citations
  • hERG gating microdomains defined by S6 mutagenesis and molecular modeling. (Wynia-Smith SL, Gillian-Daniel AL, Satyshur KA, Robertson GA) J Gen Physiol 2008 Nov;132(5):507-20 PMID: 18955593 PMCID: PMC2571969 SCOPUS ID: 2-s2.0-59449096598 10/29/2008       43 Citations
    • Last update: 04/16/2025