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Seung-Keun Hong PhD
Research Scientist II
Institution:
Medical College of Wisconsin
Department:
Anesthesiology
Division:
Research
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Publications (33)
Prolonged warm ischemia time increases mitogen-activated protein kinase activity and decreases perfusate cytokine levels in
ex vivo
rat liver machine perfusion.
(Kim J, Hong SK, Yang Y, Lee A, Hoffmeister KM, Gantner BN, Park JI)
Front Transplant
2023;2:1215182 PMID: 38993858 PMCID: PMC11235240 SCOPUS ID: 2-s2.0-85204385238 07/12/2024
Assessing the degree of hepatic ischemia-reperfusion injury using physiologically based pharmacokinetic modeling of sodium fluorescein disposition in ex vivo machine-perfused livers.
(Monti CE, Hong SK, Audi SH, Lee W, Joshi A, Terhune SS, Kim J, Dash RK)
Am J Physiol Gastrointest Liver Physiol
2024 Sep 01;327(3):G424-G437 PMID: 38917324 PMCID: PMC11427087 SCOPUS ID: 2-s2.0-85202790681 06/25/2024
Physiologically-Based Pharmacokinetic Modeling of Blood Clearance of Liver Fluorescent Markers for the Assessment of the Degree of Hepatic Ischemia-Reperfusion Injury
.
(Monti C, Audi SH, Womack J, Hong SK, Yang Y, Kim J, Dash RK)
Annu Int Conf IEEE Eng Med Biol Soc
2023 Jul;2023:1-6 PMID: 38082711 SCOPUS ID: 2-s2.0-85179643663 12/12/2023
Fluorescein clearance kinetics in blood and bile indicates hepatic ischemia-reperfusion injury in rats.
(Kim J, Yang Y, Hong SK, Zielonka J, Dash RK, Audi SH, Kumar SN, Joshi A, Zimmerman MA, Hong JC)
Am J Physiol Gastrointest Liver Physiol
2022 Aug 01;323(2):G126-G133 PMID: 35700191 SCOPUS ID: 2-s2.0-85134761396 06/15/2022
1 Citation
Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells
(Seung-Keun Hong, Dmytro Starenki, Oleta T Johnson, Jason E Gestwicki, Jong-In Park)
International Journal of Molecular Sciences
01/19/2022
Mortalin depletion induces MEK/ERK-dependent and ANT/CypD-mediated death in vemurafenib-resistant B-RafV600E melanoma cells
(Pui-Kei Wu, Seung-Keun Hong, Jong-In Park)
Cancer Letters
04/01/2021
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability
(Pui-Kei Wu, Seung-Keun Hong, Dmytro Starenki, Kiyoko Oshima, Hao Shao, Jason E Gestwicki, Susan Tsai, Jong-In Park)
Oncogene
04/14/2020
Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability
(Pui-Kei Wu, Seung-Keun Hong, Wenjing Chen, Andrew E Becker, Rebekah L Gundry, Chien-Wei Lin, Hao Shao, Jason E Gestwicki, Jong-In Park)
Science signaling
03/10/2020
Mortalin (GRP75/HSPA9) promotes survival and proliferation of thyroid carcinoma cells
(Dmytro Starenki, Nadiya Sosonkina, Seung-Keun Hong, Ricardo V Lloyd, Jong-In Park)
International Journal of Molecular Sciences
04/26/2019
A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses
(Seung-Keun Hong, Pui-Kei Wu, Jong-In Park)
Cellular signalling
01/01/2018
Steady-state levels of phosphorylated mitogen-activated protein kinase kinase 1/2 determined by mortalin/HSPA9 and protein phosphatase 1 alpha in KRAS and BRAF tumor cells
(Pui-Kei Wu, Seung-Keun Hong, Jong-In Park)
Molecular and Cellular Biology
09/15/2017
Vandetanib and cabozantinib potentiate mitochondria-targeted agents to suppress medullary thyroid carcinoma cells
(Dmytro Starenki, Seung-Keun Hong, Pui-Kei Wu, Jong-In Park)
Cancer biology & therapy
07/03/2017
Suppression of B-RafV600E melanoma cell survival by targeting mitochondria using triphenyl-phosphonium-conjugated nitroxide or ubiquinone
(Seung-Keun Hong, Dmytro Starenki, Pui-Kei Wu, Jong-In Park)
Cancer biology & therapy
02/01/2017
ERK1/2 can feedback-regulate cellular MEK1/2 levels
(Seung-Keun Hong, Pui-Kei Wu, Mansi Karkhanis, Jong-In Park)
Cellular signalling
10/01/2015
Active ERK 2 is sufficient to mediate growth arrest and differentiation signaling
(Pui–Kei Wu, Seung–Keun Hong, Seung–Hee Yoon, Jong–In Park)
The FEBS journal
01/16/2015
Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells
(Dmytro Starenki, Seung-Keun Hong, RV Lloyd, Jong-In Park)
Oncogene
12/01/2014
Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels
(Jin-Hwan Kim, Seung-Keun Hong, Pui-Kei Wu, Alexsia L Richards, William T Jackson, Jong-In Park)
Experimental cell research
10/01/2014
Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines
(Nadiya Sosonkina, Seung-Keun Hong, Dmytro Starenki, Jong-In Park)
Genes & Genomics
08/27/2014
A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase
(Pui-Kei Wu, Seung-Keun Hong, Sudhakar Veeranki, Mansi Karkhanis, Dmytro Starenki, Jose A Plaza, Jong-In Park)
Molecular and cellular biology
10/15/2013
Autophagy sensitivity of neuroendocrine lung tumor cells
(Seung-Keun Hong, Jin-Hwan Kim, Dmytro Starenki, Jong-In Park)
International journal of oncology
10/11/2013
AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion
(Seung-Keun Hong, Joseph H Jeong, Andrew M Chan, Jong-In Park)
Experimental cell research
05/20/2013
Interaction between Saccharomyces cerevisiae glutaredoxin 5 and SPT10 and their in vivo functions
(Young-Mee Oh, Seung-Keun Hong, Jeong-Tae Yeon, Mee-Kyung Cha, Il-Han Kim)
Free Radical Biology and Medicine
05/01/2012
The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
(Seung-Keun Hong, Jin-Hwan Kim, Ming-Fong Lin, Jong-In Park)
Experimental cell research
11/01/2011
Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells
(Dumrongkiet Arthan, Seung-Keun Hong, Jong-In Park)
Cancer letters
11/01/2010
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling
(Seung-Keun Hong, Seunghee Yoon, Cas Moelling, Dumrongkiet Arthan, Jong-In Park)
Journal of Biological Chemistry
11/27/2009
A glutaredoxin-fused thiol peroxidase acts as an important player in hydrogen peroxide detoxification in late-phased growth of Anabaena sp. PCC7120
(Seung-Keun Hong, Mee-Kyung Cha, Il-Han Kim)
Archives of biochemistry and biophysics
07/01/2008
Four thiol peroxidases contain a conserved GCT catalytic motif and act as a versatile array of lipid peroxidases in Anabaena sp. PCC7120
(Mee-Kyung Cha, Seung-Keun Hong, Il-Han Kim)
Free Radical Biology and Medicine
06/01/2007
Specific protein interaction of human Pag with Omi/HtrA2 and the activation of the protease activity of Omi/HtrA2
(Seung-Keun Hong, Mee-Kyung Cha, Il-Han Kim)
Free Radical Biology and Medicine
01/15/2006
Vibrio cholerae thiol peroxidase-glutaredoxin fusion is a 2-Cys TSA/AhpC subfamily acting as a lipid hydroperoxide reductase
(Mee-Kyung Cha, Seung-Keun Hong, Dong-Suk Lee, Il-Han Kim)
Journal of Biological Chemistry
03/19/2004
The protein interaction of Saccharomyces cerevisiae cytoplasmic thiol peroxidase II with SFH2p and its in vivo function
(Mee-Kyung Cha, Seung-Keun Hong, Young-Mee Oh, Il-Han Kim)
Journal of Biological Chemistry
09/12/2003
Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae
(Mee-Kyung Cha, Yong-Soo Choi, Seung-Keun Hong, Won-Cheol Kim, Kyoung Tai No, Il-Han Kim)
Journal of Biological Chemistry
07/04/2003
Msn2p/Msn4p act as a key transcriptional activator of yeast cytoplasmic thiol peroxidase II
(Seung-Keun Hong, Mee-Kyung Cha, Yong-Soo Choi, Won-Cheol Kim, Il-Han Kim)
Journal of Biological Chemistry
04/05/2002
Glutamic Acid Rich Helix II Domain of the HIV-1 Vpu has Transactivation Potential in Yeast
(Seung-Keun Hong, Yong-Soo Bae, Jung-Woo Kim)
BMB Reports
05/05/1999
Last update: 01/03/2025