Medical College of Wisconsin
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Sevasti Koukouritaki PhD

Research Scientist II

Institution: Medical College of Wisconsin
Department: Pediatrics
Division: Hematology and Oncology - Pediatrics
Program: Oncology

Publications (27)

  • Phosphorylation of distal C-terminal residues promotes TRPV4 channel activation in response to arachidonic acid. (Parthasarathy A, Anishkin A, Xie Y, Drachuk K, Nishijma Y, Fang J, Koukouritaki SB, Wilcox DA, Zhang DX) J Biol Chem 2025 Mar;301(3):108260 PMID: 39909371 PMCID: PMC11903807 SCOPUS ID: 2-s2.0-85218338007 02/06/2025    
  • A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia. (Koukouritaki SB, Thinn AMM, Ashworth KJ, Fang J, Slater HS, Du LM, Nguyen HTT, Pillois X, Nurden AT, Ng CJ, Di Paola J, Zhu J, Wilcox DA) Blood Adv 2023 Jul 11;7(13):3180-3191 PMID: 36884296 PMCID: PMC10338211 SCOPUS ID: 2-s2.0-85179497686 03/09/2023       2 Citations
  • High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia. (Sullivan SK, Mills JA, Koukouritaki SB, Vo KK, Lyde RB, Paluru P, Zhao G, Zhai L, Sullivan LM, Wang Y, Kishore S, Gharaibeh EZ, Lambert MP, Wilcox DA, French DL, Poncz M, Gadue P) Blood 2014 Jan 30;123(5):753-7 PMID: 24335497 PMCID: PMC3907760 SCOPUS ID: 2-s2.0-84897024164 12/18/2013       51 Citations
  • Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. (Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Raymer RA, Fang J, Koukouritaki SB, Jacobi PM, Hawkins TB, Cornetta K, Shi Q, Wilcox DA) Nat Commun 2013;4:2773 PMID: 24253479 PMCID: PMC3868233 SCOPUS ID: 2-s2.0-84893419411 11/21/2013       103 Citations
  • Platelet gene therapy improves hemostatic function for integrin alphaIIbbeta3-deficient dogs. (Fang J, Jensen ES, Boudreaux MK, Du LM, Hawkins TB, Koukouritaki SB, Cornetta K, Wilcox DA) Proc Natl Acad Sci U S A 2011 Jun 07;108(23):9583-8 PMID: 21606353 PMCID: PMC3111318 SCOPUS ID: 2-s2.0-79959329020 05/25/2011       51 Citations
  • Regulatory polymorphisms and their contribution to interindividual differences in the expression of enzymes influencing drug and toxicant disposition. (Hines RN, Koukouritaki SB, Poch MT, Stephens MC) Drug Metab Rev 2008;40(2):263-301 PMID: 18464046 SCOPUS ID: 2-s2.0-44649129253 05/09/2008       18 Citations
  • Identification and functional analysis of common human flavin-containing monooxygenase 3 genetic variants. (Koukouritaki SB, Poch MT, Henderson MC, Siddens LK, Krueger SK, VanDyke JE, Williams DE, Pajewski NM, Wang T, Hines RN) J Pharmacol Exp Ther 2007 Jan;320(1):266-73 PMID: 17050781 SCOPUS ID: 2-s2.0-33845940735 10/20/2006       64 Citations
  • Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygenases and peroxidases. (Vyas PM, Roychowdhury S, Koukouritaki SB, Hines RN, Krueger SK, Williams DE, Nauseef WM, Svensson CK) J Pharmacol Exp Ther 2006 Oct;319(1):497-505 PMID: 16857727 SCOPUS ID: 2-s2.0-33749010103 07/22/2006       67 Citations
  • Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre- and postnatal human liver. (Duanmu Z, Weckle A, Koukouritaki SB, Hines RN, Falany JL, Falany CN, Kocarek TA, Runge-Morris M) J Pharmacol Exp Ther 2006 Mar;316(3):1310-7 PMID: 16339912 SCOPUS ID: 2-s2.0-33644754574 12/13/2005       96 Citations
  • Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. (Koukouritaki SB, Hines RN) Pharmacogenomics 2005 Dec;6(8):807-22 PMID: 16296944 SCOPUS ID: 2-s2.0-28444441585 11/22/2005       56 Citations
  • Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants. (Koukouritaki SB, Poch MT, Cabacungan ET, McCarver DG, Hines RN) Mol Pharmacol 2005 Aug;68(2):383-92 PMID: 15858076 SCOPUS ID: 2-s2.0-23044469807 04/29/2005       67 Citations
  • Erratum: Human Hepatic CYP2E1 Expression during Development (Journal of Pharmacology and Experimental Therapeutics (2003) 307 (402-407) DOI: 10.1124/jpet.103.053124) (Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG) Journal of Pharmacology and Experimental Therapeutics April 2004;309(1):439 SCOPUS ID: 2-s2.0-1642395400 04/01/2004    
  • Developmental expression of human hepatic CYP2C9 and CYP2C19. (Koukouritaki SB, Manro JR, Marsh SA, Stevens JC, Rettie AE, McCarver DG, Hines RN) J Pharmacol Exp Ther 2004 Mar;308(3):965-74 PMID: 14634042 SCOPUS ID: 2-s2.0-1342344547 11/25/2003       278 Citations
  • Human hepatic CYP2E1 expression during development. (Johnsrud EK, Koukouritaki SB, Divakaran K, Brunengraber LL, Hines RN, McCarver DG) J Pharmacol Exp Ther 2003 Oct;307(1):402-7 PMID: 14500779 SCOPUS ID: 2-s2.0-0141519338 09/23/2003       159 Citations
  • Developmental expression of the major human hepatic CYP3A enzymes. (Stevens JC, Hines RN, Gu C, Koukouritaki SB, Manro JR, Tandler PJ, Zaya MJ) J Pharmacol Exp Ther 2003 Nov;307(2):573-82 PMID: 12975492 SCOPUS ID: 2-s2.0-0142210233 09/17/2003       332 Citations
  • Genetic variability at the human FMO1 locus: significance of a basal promoter yin yang 1 element polymorphism (FMO1*6). (Hines RN, Luo Z, Hopp KA, Cabacungan ET, Koukouritaki SB, McCarver DG) J Pharmacol Exp Ther 2003 Sep;306(3):1210-8 PMID: 12829732 SCOPUS ID: 2-s2.0-0041932063 06/28/2003       39 Citations
  • Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression. (Koukouritaki SB, Simpson P, Yeung CK, Rettie AE, Hines RN) Pediatr Res 2002 Feb;51(2):236-43 PMID: 11809920 SCOPUS ID: 2-s2.0-0036157094 01/26/2002       221 Citations
  • Tyrosine phosphorylation of focal adhesion kinase and paxillin regulates the signaling mechanism of the rapid nongenomic action of dexamethasone on actin cytoskeleton. (Koukouritaki SB, Gravanis A, Stournaras C) Mol Med 1999 Nov;5(11):731-42 PMID: 10656875 PMCID: PMC2230481 SCOPUS ID: 2-s2.0-0033276623 02/05/2000       49 Citations
  • Heme oxygenase-1 induction attenuates inducible nitric oxide synthase expression and proteinuria in glomerulonephritis. (Datta PK, Koukouritaki SB, Hopp KA, Lianos EA) J Am Soc Nephrol 1999 Dec;10(12):2540-50 PMID: 10589693 SCOPUS ID: 2-s2.0-0032586005 12/10/1999       105 Citations
  • Enhanced expression of the cytoskeleton-associated proteins paxillin and focal adhesion kinase in glomerular immune injury. (Koukouritaki SB, Tamizuddin A, Lianos EA) J Lab Clin Med 1999 Aug;134(2):173-9 PMID: 10444032 SCOPUS ID: 2-s2.0-0033180291 08/12/1999       12 Citations
  • TNF-alpha induces actin cytoskeleton reorganization in glomerular epithelial cells involving tyrosine phosphorylation of paxillin and focal adhesion kinase. (Koukouritaki SB, Vardaki EA, Papakonstanti EA, Lianos E, Stournaras C, Emmanouel DS) Mol Med 1999 Jun;5(6):382-92 PMID: 10415163 PMCID: PMC2230436 SCOPUS ID: 2-s2.0-0032782860 07/23/1999       81 Citations
  • Glucocorticoid effect on human mesangial cell cytoskeletal proteins. (Koukouritaki SB, Lianos EA) J Lab Clin Med 1999 Apr;133(4):378-83 PMID: 10218769 SCOPUS ID: 2-s2.0-0033117670 04/28/1999       11 Citations
  • Enhanced expression of the cytoskeletal-associated protein, paxillin, in experimental nephrotic syndrome. (Koukouritaki SB, Tamizuddin A, Lianos EA) J Investig Med 1998 Aug;46(6):284-9 PMID: 9737090 SCOPUS ID: 2-s2.0-0032133908 09/16/1998       9 Citations
  • Dexamethasone induces rapid actin assembly in human endometrial cells without affecting its synthesis. (Koukouritaki SB, Margioris AN, Gravanis A, Hartig R, Stournaras C) J Cell Biochem 1997 Jun 15;65(4):492-500 PMID: 9178099 SCOPUS ID: 2-s2.0-0030988624 06/15/1997       48 Citations
  • Altered actin polymerization dynamics in various malignant cell types: evidence for differential sensitivity to cytochalasin B. (Stournaras C, Stiakaki E, Koukouritaki SB, Theodoropoulos PA, Kalmanti M, Fostinis Y, Gravanis A) Biochem Pharmacol 1996 Nov 08;52(9):1339-46 PMID: 8937443 SCOPUS ID: 2-s2.0-0030575907 11/08/1996       70 Citations
  • Dexamethasone alters rapidly actin polymerization dynamics in human endometrial cells: evidence for nongenomic actions involving cAMP turnover. (Koukouritaki SB, Theodoropoulos PA, Margioris AN, Gravanis A, Stournaras C) J Cell Biochem 1996 Aug;62(2):251-61 PMID: 8844405 SCOPUS ID: 2-s2.0-0029847569 08/01/1996       69 Citations
  • Differences in the G/total actin ratio and microfilament stability between normal and malignant human keratinocytes. (Katsantonis J, Tosca A, Koukouritaki SB, Theodoropoulos PA, Gravanis A, Stournaras C) Cell Biochem Funct 1994 Dec;12(4):267-74 PMID: 7834816 SCOPUS ID: 2-s2.0-0028153442 12/01/1994       55 Citations
    • Last update: 04/08/2025