Medical College of Wisconsin
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Thiago Milech De Assuncao

Research Scientist II

Institution: Medical College of Wisconsin
Department: Cell Biology Neurobiology and Anatomy

Publications (37)

  • Discovery of a MET -driven monogenic cause of steatotic liver disease. (Pinto E Vairo F, Zimmermann MT, Wagenknecht J, Jorge SD, Tian S, Vierkant RA, Luehrs AC, Milech de Assunção T, Mathison A, Atwal PS, Cao Y, Allen AM, Klee EW, Urrutia R, Lazaridis KN) Hepatology 2025 Dec 01;82(6):1512-1522 PMID: 39879586 SCOPUS ID: 2-s2.0-85217105777 01/29/2025    
  • Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape. (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) Comput Struct Biotechnol J 2023;21:4790-4803 PMID: 37841325 PMCID: PMC10570560 SCOPUS ID: 2-s2.0-85173171942 10/16/2023       8 Citations
  • Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry. (Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G) Biosci Rep 2023 Oct 31;43(10) PMID: 37782747 PMCID: PMC10611923 SCOPUS ID: 2-s2.0-85175273435 10/02/2023       2 Citations
  • Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape. (Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Esparza GV, Leverence EN, De Assuncao TM, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT) bioRxiv 2023 Apr 28 PMID: 37207265 PMCID: PMC10189839 05/19/2023    
  • Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R) Comput Struct Biotechnol J 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022       10 Citations
  • KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. (Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R) Genome Biol 2021 Oct 14;22(1):289 PMID: 34649604 PMCID: PMC8518179 SCOPUS ID: 2-s2.0-85117299300 10/16/2021       11 Citations
  • Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation. (Jalan-Sakrikar N, De Assuncao TM, Navarro-Corcuera A, Hamdan FH, Loarca L, Kirkeby LA, Resch ZT, O'Hara SP, Juran BD, Lazaridis KN, Rosen CB, Heimbach JK, Taner T, Shah VH, LaRusso NF, Huebert RC) Hepatol Commun 2022 Feb;6(2):345-360 PMID: 34519176 PMCID: PMC8793999 SCOPUS ID: 2-s2.0-85113394075 09/15/2021       21 Citations
  • Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. (Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Proteins 2022 Jan;90(1):282-298 PMID: 34414607 PMCID: PMC8671179 SCOPUS ID: 2-s2.0-85114677469 08/21/2021       4 Citations
  • Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks. (Urrutia G, de Assuncao TM, Mathison AJ, Salmonson A, Kerketta R, Zeighami A, Stodola TJ, Adsay V, Pehlivanoglu B, Dwinell MB, Zimmermann MT, Iovanna JL, Urrutia R, Lomberk G) Front Cell Dev Biol 2021;9:681153 PMID: 34249932 PMCID: PMC8261250 SCOPUS ID: 2-s2.0-85116952280 07/13/2021       8 Citations
  • Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. (Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R) Orphanet J Rare Dis 2021 Feb 05;16(1):66 PMID: 33546721 PMCID: PMC7866879 SCOPUS ID: 2-s2.0-85100579633 02/07/2021       14 Citations
  • Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis. (Aseem SO, Jalan-Sakrikar N, Chi C, Navarro-Corcuera A, De Assuncao TM, Hamdan FH, Chowdhury S, Banales JM, Johnsen SA, Shah VH, Huebert RC) Gastroenterology 2021 Feb;160(3):889-905.e10 PMID: 33058867 PMCID: PMC7878301 SCOPUS ID: 2-s2.0-85099152002 10/16/2020       48 Citations
  • Quantitative assessment of portal hypertension with bi-parametric dual-frequency hepatic MR elastography in mouse models. (Li J, Sehrawat TS, Chen J, Hilscher MB, Glaser KJ, Arab JP, De Assuncao TM, Simonetto DA, Mounajjed T, Manduca A, Ehman RL, Shah VH, Yin M) Eur Radiol 2021 Apr;31(4):2303-2311 PMID: 33026502 PMCID: PMC7981248 SCOPUS ID: 2-s2.0-85092181151 10/08/2020       6 Citations
  • Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. (Gao J, Wei B, de Assuncao TM, Liu Z, Hu X, Ibrahim S, Cooper SA, Cao S, Shah VH, Kostallari E) J Hepatol 2020 Nov;73(5):1144-1154 PMID: 32389810 PMCID: PMC7572579 SCOPUS ID: 2-s2.0-85087927099 05/12/2020       266 Citations
  • Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. (Arab JP, Cabrera D, Sehrawat TS, Jalan-Sakrikar N, Verma VK, Simonetto D, Cao S, Yaqoob U, Leon J, Freire M, Vargas JI, De Assuncao TM, Kwon JH, Guo Y, Kostallari E, Cai Q, Kisseleva T, Oh Y, Arrese M, Huebert RC, Shah VH) J Hepatol 2020 Jul;73(1):149-160 PMID: 32087348 PMCID: PMC7305991 SCOPUS ID: 2-s2.0-85083006307 02/23/2020       58 Citations
  • Discovery, expression, cellular localization, and molecular properties of a novel, alternative spliced HP1γ isoform, lacking the chromoshadow domain. (Mathison A, Milech De Assuncao T, Dsouza NR, Williams M, Zimmermann MT, Urrutia R, Lomberk G) PLoS One 2020;15(2):e0217452 PMID: 32027651 PMCID: PMC7004349 SCOPUS ID: 2-s2.0-85079081692 02/07/2020       5 Citations
  • Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse. (Urrutia G, Salmonson A, Toro-Zapata J, de Assuncao TM, Mathison A, Dusetti N, Iovanna J, Urrutia R, Lomberk G) Mol Cancer Res 2020 Mar;18(3):448-462 PMID: 31822519 PMCID: PMC7056528 SCOPUS ID: 2-s2.0-85081130002 12/12/2019       16 Citations
  • Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis. (Jalan-Sakrikar N, De Assuncao TM, Shi G, Aseem SO, Chi C, Shah VH, Huebert RC) Hepatology 2019 Nov;70(5):1674-1689 PMID: 31070797 PMCID: PMC6819212 SCOPUS ID: 2-s2.0-85067857736 05/10/2019       25 Citations
  • Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. (Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH) Cell Mol Gastroenterol Hepatol 2019;7(1):197-209 PMID: 30539787 PMCID: PMC6282644 SCOPUS ID: 2-s2.0-85057853914 12/13/2018       67 Citations
  • Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. (Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH) JCI Insight 2017 Dec 21;2(24) PMID: 29263300 PMCID: PMC5752303 SCOPUS ID: 2-s2.0-85050938173 12/22/2017       22 Citations
  • Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. (Loarca L, De Assuncao TM, Jalan-Sakrikar N, Bronk S, Krishnan A, Huang B, Morton L, Trussoni C, Bonilla LM, Krueger E, O'Hara S, Splinter P, Shi G, Pisarello MJL, Gores GJ, Huebert RC, LaRusso NF) Lab Invest 2017 Nov;97(11):1385-1396 PMID: 28892096 PMCID: PMC5664217 SCOPUS ID: 2-s2.0-85032465634 09/12/2017       42 Citations
  • Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. (Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G) Mol Cancer Res 2017 Aug;15(8):984-997 PMID: 28442587 PMCID: PMC5705946 SCOPUS ID: 2-s2.0-85026643394 04/27/2017       18 Citations
  • Regenerative Medicine and the Biliary Tree. (De Assuncao TM, Jalan-Sakrikar N, Huebert RC) Semin Liver Dis 2017 Feb;37(1):17-27 PMID: 28201845 PMCID: PMC5479436 SCOPUS ID: 2-s2.0-85013098496 02/16/2017       29 Citations
  • The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice. (Maiers JL, Kostallari E, Mushref M, deAssuncao TM, Li H, Jalan-Sakrikar N, Huebert RC, Cao S, Malhi H, Shah VH) Hepatology 2017 Mar;65(3):983-998 PMID: 28039913 PMCID: PMC5319908 SCOPUS ID: 2-s2.0-85007452945 01/01/2017       98 Citations
  • Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion. (Jalan-Sakrikar N, De Assuncao TM, Lu J, Almada LL, Lomberk G, Fernandez-Zapico ME, Urrutia R, Huebert RC) PLoS One 2016;11(12):e0168266 PMID: 27936185 PMCID: PMC5148157 SCOPUS ID: 2-s2.0-85005949179 12/10/2016       15 Citations
  • Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. (Wang R, Ding Q, De Assuncao TM, Mounajjed T, Maiers JL, Dou C, Cao S, Yaqoob U, Huebert RC, Shah VH) Am J Pathol 2017 Jan;187(1):134-145 PMID: 27840081 PMCID: PMC5225297 SCOPUS ID: 2-s2.0-85006355344 11/15/2016       6 Citations
  • Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy. (Lu J, Zhou Y, Hu T, Zhang H, Shen M, Cheng P, Dai W, Wang F, Chen K, Zhang Y, Wang C, Li J, Zheng Y, Yang J, Zhu R, Wang J, Lu W, Zhang H, Wang J, Xia Y, De Assuncao TM, Jalan-Sakrikar N, Huebert RC, Bin Zhou, Guo C) Sci Rep 2016 Mar 08;6:22754 PMID: 26951801 PMCID: PMC4782135 SCOPUS ID: 2-s2.0-84960449963 03/10/2016       59 Citations
  • Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration. (Wang R, Ding Q, Yaqoob U, de Assuncao TM, Verma VK, Hirsova P, Cao S, Mukhopadhyay D, Huebert RC, Shah VH) J Biol Chem 2015 Dec 25;290(52):30684-96 PMID: 26534962 PMCID: PMC4692200 SCOPUS ID: 2-s2.0-84951754288 11/05/2015       209 Citations
  • The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. (Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G) BMC Dev Biol 2015 May 29;15:23 PMID: 26021315 PMCID: PMC4448908 SCOPUS ID: 2-s2.0-84930204241 05/30/2015       6 Citations
  • Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. (De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC) Lab Invest 2015 Jun;95(6):684-96 PMID: 25867762 PMCID: PMC4447567 SCOPUS ID: 2-s2.0-84929851353 04/14/2015       69 Citations
  • Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. (Simonetto DA, Yang HY, Yin M, de Assuncao TM, Kwon JH, Hilscher M, Pan S, Yang L, Bi Y, Beyder A, Cao S, Simari RD, Ehman R, Kamath PS, Shah VH) Hepatology 2015 Feb;61(2):648-59 PMID: 25142214 PMCID: PMC4303520 SCOPUS ID: 2-s2.0-84921483405 08/22/2014       178 Citations
  • Biochemical characterization of Mycobacterium tuberculosis IMP dehydrogenase: kinetic mechanism, metal activation and evidence of a cooperative system (Diana Carolina Rostirolla, Thiago Milech de Assunção, Cristiano Valim Bizarro, Luiz Augusto Basso and Diogenes Santiago Santos ) RSC Advances 05/29/2014    
  • Real time PCR quantification of viable Mycobacterium tuberculosis from sputum samples treated with propidium monoazide. (de Assunção TM, Batista EL Jr, Deves C, Villela AD, Pagnussatti VE, de Oliveira Dias AC, Kritski A, Rodrigues-Junior V, Basso LA, Santos DS) Tuberculosis (Edinb) 2014 Jul;94(4):421-7 PMID: 24863654 SCOPUS ID: 2-s2.0-84902550408 05/28/2014       14 Citations
  • FGF21 promotes endothelial cell angiogenesis through a dynamin-2 and Rab5 dependent pathway. (Yaqoob U, Jagavelu K, Shergill U, de Assuncao T, Cao S, Shah VH) PLoS One 2014;9(5):e98130 PMID: 24848261 PMCID: PMC4029959 SCOPUS ID: 2-s2.0-84901326911 05/23/2014       27 Citations
  • New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. (de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH) J Biol Chem 2014 May 30;289(22):15798-809 PMID: 24759103 PMCID: PMC4140934 SCOPUS ID: 2-s2.0-84901702509 04/25/2014       47 Citations
  • HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol-induced parenchymal cell injury. (Seo YS, Kwon JH, Yaqoob U, Yang L, De Assuncao TM, Simonetto DA, Verma VK, Shah VH) Am J Physiol Gastrointest Liver Physiol 2013 Dec;305(11):G838-48 PMID: 24091596 PMCID: PMC3882432 SCOPUS ID: 2-s2.0-84889050421 10/05/2013       49 Citations
  • The transition state analog inhibitor of Purine Nucleoside Phosphorylase (PNP) Immucillin-H arrests bone loss in rat periodontal disease models. (Deves C, de Assunção TM, Ducati RG, Campos MM, Basso LA, Santos DS, Batista EL Jr) Bone 2013 Jan;52(1):167-75 PMID: 23026564 SCOPUS ID: 2-s2.0-84867593849 10/03/2012       6 Citations
  • Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment. (Yaqoob U, Cao S, Shergill U, Jagavelu K, Geng Z, Yin M, de Assuncao TM, Cao Y, Szabolcs A, Thorgeirsson S, Schwartz M, Yang JD, Ehman R, Roberts L, Mukhopadhyay D, Shah VH) Cancer Res 2012 Aug 15;72(16):4047-59 PMID: 22738912 PMCID: PMC3421041 SCOPUS ID: 2-s2.0-84865140752 06/29/2012       126 Citations
    • Last update: 06/02/2025