Medical College of Wisconsin
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Thomas Mcfall PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Biochemistry

Member of the Cancer Center

View Curriculum Vitae

Publications (18)

  • KRASG12R-Mutant Pancreatic Cancer Features Limited ERK/MAPK Transcriptional Activity and a Distinctive Tumor Microenvironment. (Burge RA, Le Roux O, Popow O, Spadafora VK, Rajesh C, Adair SJ, Bialousow L, Murphy C, Saberi S, Vaena SG, Taquey MC, Allen S, Han L, Helke KL, Sharma S, Ostrowski MC, Guttridge DC, Dincman TA, Bauer TW, Kashatus DF, McFall T, Haigis KM, Hollingsworth MA, Counter CM, Der CJ, Hobbs GA) Cancer Res 2026 Apr 15;86(8):1868-1882 PMID: 41556816 PMCID: PMC13080325 SCOPUS ID: 2-s2.0-105035919044 01/20/2026       1 Citation
  • Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma. (Kamgar M, Hobbes GA, Davidson R, Dorbin D, Herrera J, Langenheim JF, Burge RA, Aldakkak M, Conrardy RD, Szabo A, Thalji SZ, Mayer B, Grahl JJ, Chung BY, Phan A, Thomas JP, Seo YD, Evans DB, Christians KK, Erickson B, Hall WA, George B, Tsai S, Lytle NK, Der CJ, Kurzrock R, McFall T) Cancer Res 2026 Apr 15;86(8):2042-2059 PMID: 41134578 PMCID: PMC13080315 SCOPUS ID: 2-s2.0-105031984871 10/24/2025       1 Citation
  • Pancreatic Cells Are Resistant to KRASQ61L Expression due to Hyperactive ERK/MAPK Signaling and Apoptosis Induction. (Burge RA, Bialousow L, McFall T, Bamonte L, Johnson G, Smith M, Vaena SG, Comte-Walters S, Ball LE, Berto S, O'Bryan JP, Hobbs GA) Cancer Res Commun 2025 Oct 01;5(10):1865-1878 PMID: 40951926 PMCID: PMC12541299 SCOPUS ID: 2-s2.0-105019811183 09/15/2025    
  • Chemotherapy-free treatment targeting fusions and driver mutations in KRAS wild-type pancreatic ductal adenocarcinoma, a case series. (Mehdi M, Szabo A, Shreenivas A, Thomas JP, Tsai S, Christians KK, Evans DB, Clarke CN, Hall WA, Erickson B, Ahmed G, Thapa B, McFall T, George B, Kurzrock R, Kamgar M) Ther Adv Med Oncol 2024;16:17588359241253113 PMID: 38770091 PMCID: PMC11104030 SCOPUS ID: 2-s2.0-85193752803 05/21/2024       5 Citations
  • Transcriptomic-Based Microenvironment Classification Reveals Precision Medicine Strategies for Pancreatic Ductal Adenocarcinoma. (George B, Kudryashova O, Kravets A, Thalji S, Malarkannan S, Kurzrock R, Chernyavskaya E, Gusakova M, Kravchenko D, Tychinin D, Savin E, Alekseeva L, Butusova A, Bagaev A, Shin N, Brown JH, Sethi I, Wang D, Taylor B, McFall T, Kamgar M, Hall WA, Erickson B, Christians KK, Evans DB, Tsai S) Gastroenterology 2024 May;166(5):859-871.e3 PMID: 38280684 SCOPUS ID: 2-s2.0-85188891214 01/28/2024       23 Citations
  • Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP. (McFall T, Trogdon M, Guizar AC, Langenheim JF, Sisk-Hackworth L, Stites EC) NPJ Precis Oncol 2022 Nov 23;6(1):86 PMID: 36418474 PMCID: PMC9684405 SCOPUS ID: 2-s2.0-85142447563 11/24/2022       16 Citations
  • Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach. (McFall T, Stites EC) Cell Rep 2021 Dec 14;37(11):110096 PMID: 34910921 PMCID: PMC8867612 SCOPUS ID: 2-s2.0-85121146579 12/16/2021       17 Citations
  • KRAS-Mutated, Estrogen Receptor-Positive Low-Grade Serous Ovarian Cancer: Unraveling an Exceptional Response Mystery. (Kato S, McFall T, Takahashi K, Bamel K, Ikeda S, Eskander RN, Plaxe S, Parker B, Stites E, Kurzrock R) Oncologist 2021 Apr;26(4):e530-e536 PMID: 33528846 PMCID: PMC8018312 SCOPUS ID: 2-s2.0-85101866994 02/03/2021       10 Citations
  • Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors. (McFall T, Schomburg NK, Rossman KL, Stites EC) Cell Commun Signal 2020 Nov 05;18(1):179 PMID: 33153459 PMCID: PMC7643456 SCOPUS ID: 2-s2.0-85095115047 11/07/2020       14 Citations
  • A mechanism for the response of KRASG13D expressing colorectal cancers to EGFR inhibitors. (McFall T, Stites EC) Mol Cell Oncol 2020;7(2):1701914 PMID: 32158916 PMCID: PMC7051129 SCOPUS ID: 2-s2.0-85078303987 03/12/2020       11 Citations
  • A systems mechanism for KRAS mutant allele-specific responses to targeted therapy. (McFall T, Diedrich JK, Mengistu M, Littlechild SL, Paskvan KV, Sisk-Hackworth L, Moresco JJ, Shaw AS, Stites EC) Sci Signal 2019 Sep 24;12(600) PMID: 31551296 PMCID: PMC6864030 SCOPUS ID: 2-s2.0-85072619385 09/26/2019       50 Citations
  • Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor. (Patki M, McFall T, Rosati R, Huang Y, Malysa A, Polin L, Fielder A, Wilson MR, Lonardo F, Back J, Li J, Matherly LH, Bepler G, Ratnam M) Sci Rep 2018 Oct 30;8(1):16006 PMID: 30375484 PMCID: PMC6207728 SCOPUS ID: 2-s2.0-85055615805 10/31/2018       13 Citations
  • Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer. (Rosati R, Polin L, Ducker C, Li J, Bao X, Selvakumar D, Kim S, Xhabija B, Larsen M, McFall T, Huang Y, Kidder BL, Fribley A, Saxton J, Kakuta H, Shaw P, Ratnam M) Clin Cancer Res 2018 Dec 15;24(24):6509-6522 PMID: 30185422 PMCID: PMC6295231 SCOPUS ID: 2-s2.0-85058440559 09/07/2018       16 Citations
  • Progesterone receptor A promotes invasiveness and metastasis of luminal breast cancer by suppressing regulation of critical microRNAs by estrogen. (McFall T, McKnight B, Rosati R, Kim S, Huang Y, Viola-Villegas N, Ratnam M) J Biol Chem 2018 Jan 26;293(4):1163-1177 PMID: 29162724 PMCID: PMC5787796 SCOPUS ID: 2-s2.0-85041241242 11/23/2017       37 Citations
  • The Amino-terminal Domain of the Androgen Receptor Co-opts Extracellular Signal-regulated Kinase (ERK) Docking Sites in ELK1 Protein to Induce Sustained Gene Activation That Supports Prostate Cancer Cell Growth. (Rosati R, Patki M, Chari V, Dakshnamurthy S, McFall T, Saxton J, Kidder BL, Shaw PE, Ratnam M) J Biol Chem 2016 Dec 09;291(50):25983-25998 PMID: 27793987 PMCID: PMC5207070 SCOPUS ID: 2-s2.0-85002706288 10/30/2016       15 Citations
  • Hybrid Enzalutamide Derivatives with Histone Deacetylase Inhibitor Activity Decrease Heat Shock Protein 90 and Androgen Receptor Levels and Inhibit Viability in Enzalutamide-Resistant C4-2 Prostate Cancer Cells. (Rosati R, Chen B, Patki M, McFall T, Ou S, Heath E, Ratnam M, Qin Z) Mol Pharmacol 2016 Sep;90(3):225-37 PMID: 27382012 PMCID: PMC4998664 SCOPUS ID: 2-s2.0-84984848137 07/07/2016       21 Citations
  • Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges. (McFall T, Patki M, Rosati R, Ratnam M) Oncotarget 2015 Oct 20;6(32):33146-64 PMID: 26356672 PMCID: PMC4741755 SCOPUS ID: 2-s2.0-84946031365 09/12/2015       14 Citations
  • Glucocorticoid receptor status is a principal determinant of variability in the sensitivity of non-small-cell lung cancer cells to pemetrexed. (Patki M, Gadgeel S, Huang Y, McFall T, Shields AF, Matherly LH, Bepler G, Ratnam M) J Thorac Oncol 2014 Apr;9(4):519-26 PMID: 24736075 PMCID: PMC4075060 SCOPUS ID: 2-s2.0-84922479677 04/17/2014       29 Citations
    • Last update: 05/04/2026