Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

William J. Peppard PharmD

William J. Peppard PharmD profile photo picture

Trauma/Surgical Critical Care Pharmacist

Institution: Froedtert Hospital
Department: Pharmacy

View Curriculum Vitae

Research Experience

  • Analgesia
  • Clinical Pharmacy Information Systems
  • Conscious Sedation
  • Critical Care
  • Deep Sedation
  • Pharmacists
  • Pharmacy Service, Hospital
  • drug therapy

    • Leadership Positions

  • Chair, Pharmacy Research, Froedtert Health

    • Publications (50)

  • Multicenter study evaluating target attainment of anti-Factor Xa levels using various enoxaparin prophylactic dosing practices in adult trauma patients. (Chanas T, Gibson G, Langenstroer E, Herrmann DJ, Carver TW, Alexander K, Chui SHJ, Rein L, Ha M, Maynard KM, Bamberg K, O'Keefe M, O'Brien M, Gonzalez MC, Hobbs B, Pajoumand M, Peppard WJ) Pharmacotherapy 2024 Mar;44(3):258-267 PMID: 38148134 SCOPUS ID: 2-s2.0-85181719372 12/27/2023    
  • A Prescribing Guideline Decreases Postoperative Opioid Prescribing in Emergency General Surgery. (Biesboer EA, Al Tannir AH, Karam BS, Tyson K, Peppard WJ, Morris R, Murphy P, Elegbede A, de Moya MA, Trevino C) J Surg Res 2024 Jan;293:607-612 PMID: 37837815 SCOPUS ID: 2-s2.0-85173910473 10/15/2023    
  • PHarmacist avoidance or reductions in medical costs in CRITically ill adults rounding with one SERVICE compared to two or more services: PHARM-CRIT-SERVICE (Smetana KS, Flannery AH, Gurnani PK, Peppard WJ, Van Berkel Patel MA, Joyce C, Rech MA) JACCP Journal of the American College of Clinical Pharmacy September 2023;6(9):1000-1007 SCOPUS ID: 2-s2.0-85158106453 09/01/2023       1 Citation
  • Evaluation of a novel blood volume-based enoxaparin dosing guideline for venous thromboembolism prophylaxis in trauma patients. (Langenstroer EA, Carver TW, Herrmann DJ, O'Keefe MM, Hubbard S, Holschbach L, Rein L, Peppard WJ) Am J Health Syst Pharm 2023 Aug 18;80(17):1137-1146 PMID: 37256752 SCOPUS ID: 2-s2.0-85168243784 05/31/2023       1 Citation
  • Evaluation of an Association Between Enoxaparin Dose per Estimated Blood Volume and Clinically Relevant Bleeding in Low-Weight Trauma Patients. (Carter C, Denny K, Carver TW, Jung B, Rein L, Peppard WJ) Ann Pharmacother 2024 Feb;58(2):118-125 PMID: 37138511 SCOPUS ID: 2-s2.0-85158861058 05/04/2023       1 Citation
  • Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations. (Nanchal R, Subramanian R, Alhazzani W, Dionne JC, Peppard WJ, Singbartl K, Truwit J, Al-Khafaji AH, Killian AJ, Alquraini M, Alshammari K, Alshamsi F, Belley-Cote E, Cartin-Ceba R, Hollenberg SM, Galusca DM, Huang DT, Hyzy RC, Junek M, Kandiah P, Kumar G, Morgan RL, Morris PE, Olson JC, Sieracki R, Steadman R, Taylor B, Karvellas CJ) Crit Care Med 2023 May 01;51(5):657-676 PMID: 37052436 SCOPUS ID: 2-s2.0-85152596459 04/14/2023       3 Citations
  • Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations. (Nanchal R, Subramanian R, Alhazzani W, Dionne JC, Peppard WJ, Singbartl K, Truwit J, Al-Khafaji AH, Killian AJ, Alquraini M, Alshammari K, Alshamsi F, Belley-Cote E, Cartin-Ceba R, Hollenberg SM, Galusca DM, Huang DT, Hyzy RC, Junek M, Kandiah P, Kumar G, Morgan RL, Morris PE, Olson JC, Sieracki R, Steadman R, Taylor B, Karvellas CJ) Crit Care Med 2023 May 01;51(5):653-656 PMID: 37052435 SCOPUS ID: 2-s2.0-85152605549 04/14/2023    
  • Quantifying the impact of reduced opioid use in patients after emergency laparotomy. (Tchen S, Bhatt R, Peppard W, Szabo A, Dong H, Morris R, Trevino CM) Surgery 2023 Jun;173(6):1499-1507 PMID: 36948914 SCOPUS ID: 2-s2.0-85150774415 03/23/2023    
  • Effectiveness of Body Mass Index-Based Prophylactic Enoxaparin Dosing in Bariatric Surgery Patients. (Chang CK, Higgins RM, Rein L, Peppard WJ, Herrmann DJ, Kindel T) J Surg Res 2023 Jul;287:168-175 PMID: 36933548 SCOPUS ID: 2-s2.0-85150034917 03/19/2023       4 Citations
  • Optimizing discharge opioid prescribing in trauma patients: A quasi-experimental study. (Tyson K, Karam BS, Peppard WJ, Morris R, Murphy P, Elegbede A, Schroeder M, Somberg L, Trevino CM) Surgery 2023 Mar;173(3):794-798 PMID: 36371358 SCOPUS ID: 2-s2.0-85141795445 11/13/2022       1 Citation
  • A phase 2 trial of a topical antiseptic bundle in head and neck cancer surgery: Effects on surgical site infection and the oral microbiome. (Zenga J, Atkinson S, Yen T, Massey B, Stadler M, Bruening J, Peppard W, Reuben M, Hayward M, Mesich B, Buchan B, Ledeboer N, Sanchez JL, Fraser R, Lin CW, Holtz ML, Awan M, Wong SJ, Puram SV, Salzman N) EBioMedicine 2022 Jul;81:104099 PMID: 35671624 PMCID: PMC9168040 SCOPUS ID: 2-s2.0-85131428877 06/08/2022       3 Citations
  • Multicenter Retrospective Review of Ketamine Use in the ICU. (Groth CM, Droege CA, Connor KA, Kaukeinen K, Acquisto NM, Chui SHJ, Cucci MD, Dixit D, Flannery AH, Gustafson KA, Glass NE, Horng H, Heavner MS, Kinney J, Kruer RM, Peppard WJ, Sarangarm P, Sikora A, Viswesh V, Erstad BL) Crit Care Explor 2022 Feb;4(2):e0633 PMID: 35187497 PMCID: PMC8843366 SCOPUS ID: 2-s2.0-85151373606 02/22/2022       7 Citations
  • Postoperative depth of sedation and associated outcomes in free flap transfers to the head and neck (Laehn SJ, LoGuidice JA, Hettinger PC, Rein LE, Peppard WJ) Head and Neck February 2022;44(2):391-398 SCOPUS ID: 2-s2.0-85119408863 02/01/2022    
  • Evaluation of anti-factor Xa concentrations using a body mass index-based enoxaparin dosing protocol for venous thromboembolism prophylaxis in trauma patients. (O'Keefe MM, Carver TW, Herrmann DJ, Prom A, Hubbard S, Rein LE, Peppard WJ) Pharmacotherapy 2022 Mar;42(3):216-223 PMID: 35100448 SCOPUS ID: 2-s2.0-85124561975 02/01/2022       6 Citations
  • Racial equity in opioid prescribing: A pharmacist-led multidisciplinary health system assessment (Peppard W, Sheldon H, Endrizzi S, Walker R, Kirchen G, Schrang A, Nagavally S, Egede L) JACCP Journal of the American College of Clinical Pharmacy 2022 SCOPUS ID: 2-s2.0-85129331672 01/01/2022    
  • PHarmacist Avoidance or Reductions in Medical Costs in CRITically Ill Adults: PHARM-CRIT Study. (Rech MA, Gurnani PK, Peppard WJ, Smetana KS, Van Berkel MA, Hammond DA, Flannery AH) Crit Care Explor 2021 Dec;3(12):e0594 PMID: 34913039 PMCID: PMC8668016 SCOPUS ID: 2-s2.0-85129971492 12/17/2021       28 Citations
  • Inpatient Perioperative Formulary Restriction of Intravenous Acetaminophen at Vizient Partner Hospitals: A National Survey of Pharmacists (Wallskog KE, Lauderdale S, Peppard WJ, Kirkwood C, Taylor S, Johnston S) Hospital Pharmacy December 2021;56(6):650-659 SCOPUS ID: 2-s2.0-85088836005 12/01/2021    
  • Determining support for and barriers to pharmacist-driven research: Results of a national survey (O'Brien KM, Badowski ME, Bartoo AS, Peppard WJ, Schwarz K, Sharpe AR, Austin Szwak J) JACCP Journal of the American College of Clinical Pharmacy December 2021;4(12):1534-1539 SCOPUS ID: 2-s2.0-85115827603 12/01/2021    
  • Postoperative depth of sedation and associated outcomes in free flap transfers to the head and neck. (Laehn SJ, LoGuidice JA, Hettinger PC, Rein LE, Peppard WJ) Head Neck 2022 Feb;44(2):391-398 PMID: 34799940 SCOPUS ID: 2-s2.0-85119408863 11/21/2021    
  • Inpatient Perioperative Formulary Restriction of Intravenous Acetaminophen at Vizient Partner Hospitals: A National Survey of Pharmacists. (Wallskog KE, Lauderdale S, Peppard WJ, Kirkwood C, Taylor S, Johnston S) Hosp Pharm 2021 Dec;56(6):650-659 PMID: 34732917 PMCID: PMC8559031 SCOPUS ID: 2-s2.0-85088836005 11/05/2021    
  • Prospective Observational Evaluation of Predatory Journals in Critical Care Pharmacy Practice: Defining Characteristics Associated With Receiving Unsolicited Invitations to Publish. (Peppard WJ, Peppard SR, Feih JT, Kim AK, Obenberger SJ, Mulvey AF, Teng BQ, Brazauskas R, Pape KO, Gibson GA, Dzierba AL, Dobesh PP) J Pharm Pract 2023 Jun;36(3):494-500 PMID: 34645297 SCOPUS ID: 2-s2.0-85117157221 10/15/2021       1 Citation
  • PHarmacist Avoidance or Reductions in Medical Costs in Patients Presenting the EMergency Department: PHARM-EM Study. (Rech MA, Adams W, Smetana KS, Gurnani PK, Van Berkel Patel MA, Peppard WJ, Hammond DA, Flannery AH) Crit Care Explor 2021 Apr;3(4):e0406 PMID: 33912836 PMCID: PMC8078282 SCOPUS ID: 2-s2.0-85119037624 04/30/2021       25 Citations
  • Exploration of an Association Between UFH Dosing Based on Estimated Blood Volume and Venous Thromboembolism and Bleeding in the Underweight and Critically Ill. (Carter C, Betthauser KD, Peppard WJ) Ann Pharmacother 2020 Sep;54(9):935-936 PMID: 32106684 SCOPUS ID: 2-s2.0-85081950915 02/29/2020       3 Citations
  • Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary, and Renal Considerations. (Nanchal R, Subramanian R, Karvellas CJ, Hollenberg SM, Peppard WJ, Singbartl K, Truwit J, Al-Khafaji AH, Killian AJ, Alquraini M, Alshammari K, Alshamsi F, Belley-Cote E, Cartin-Ceba R, Dionne JC, Galusca DM, Huang DT, Hyzy RC, Junek M, Kandiah P, Kumar G, Morgan RL, Morris PE, Olson JC, Sieracki R, Steadman R, Taylor B, Alhazzani W) Crit Care Med 2020 Mar;48(3):e173-e191 PMID: 32058387 SCOPUS ID: 2-s2.0-85079359996 02/15/2020       71 Citations
  • Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Cardiovascular, Endocrine, Hematologic, Pulmonary and Renal Considerations: Executive Summary. (Nanchal R, Subramanian R, Karvellas CJ, Hollenberg SM, Peppard WJ, Singbartl K, Truwit J, Al-Khafaji AH, Killian AJ, Alquraini M, Alshammari K, Alshamsi F, Belley-Cote E, Cartin-Ceba R, Dionne JC, Galusca DM, Huang DT, Hyzy RC, Junek M, Kandiah P, Kumar G, Morgan RL, Morris PE, Olson JC, Sieracki R, Steadman R, Taylor B, Alhazzani W) Crit Care Med 2020 Mar;48(3):415-419 PMID: 32058375 SCOPUS ID: 2-s2.0-85079360182 02/15/2020       24 Citations
  • Antibiotic Duration and Outcome Complications for Surgical Site Infection Prevention in Traumatic Mandible Fracture. (Zein Eddine SB, Cooper-Johnson K, Ericksen F, Brookes CC, Peppard WJ, Revolinski SL, Carver TW) J Surg Res 2020 Mar;247:524-529 PMID: 31668431 SCOPUS ID: 2-s2.0-85074440328 11/02/2019       9 Citations
  • Phase 3 Pilot Randomized Controlled Trial Comparing Early Trophic Enteral Nutrition With "No Enteral Nutrition" in Mechanically Ventilated Patients With Septic Shock. (Patel JJ, Kozeniecki M, Peppard WJ, Peppard SR, Zellner-Jones S, Graf J, Szabo A, Heyland DK) JPEN J Parenter Enteral Nutr 2020 Jul;44(5):866-873 PMID: 31535394 SCOPUS ID: 2-s2.0-85073992718 09/20/2019       29 Citations
  • Ketamine infusion for pain control in elderly patients with multiple rib fractures: Results of a randomized controlled trial. (Kugler NW, Carver TW, Juul J, Peppard WJ, Boyle K, Drescher KM, Szabo A, Rein L, Somberg LB, Paul JS) J Trauma Acute Care Surg 2019 Nov;87(5):1181-1188 PMID: 31425468 SCOPUS ID: 2-s2.0-85074184716 08/20/2019       19 Citations
  • Reply to Letter: Ketamine infusion for pain control in adult patients with multiple rib fractures. (Kugler NW, Juul J, Peppard WJ, Carver TW) J Trauma Acute Care Surg 2019 Oct;87(4):1001-1003 PMID: 31136526 SCOPUS ID: 2-s2.0-85072848763 05/29/2019    
  • Continuous Etomidate Infusion for the Management of Severe Cushing Syndrome: Validation of a Standard Protocol. (Carroll TB, Peppard WJ, Herrmann DJ, Javorsky BR, Wang TS, Patel H, Zarnecki K, Findling JW) J Endocr Soc 2019 Jan 01;3(1):1-12 PMID: 30560224 PMCID: PMC6291660 SCOPUS ID: 2-s2.0-85066048597 12/19/2018       37 Citations
  • Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study. (Lewin JJ 3rd, Cook AM, Gonzales C, Merola D, Neyens R, Peppard WJ, Brophy GM, Kurczewski L, Giarratano M, Makii J, Rowe AS, Tesoro EP, Zaniewski A, Clark S, Ziai WC) Neurocrit Care 2019 Jun;30(3):609-616 PMID: 30446934 SCOPUS ID: 2-s2.0-85056659490 11/18/2018       33 Citations
  • Ketamine infusion for pain control in adult patients with multiple rib fractures: Results of a randomized control trial. (Carver TW, Kugler NW, Juul J, Peppard WJ, Drescher KM, Somberg LB, Szabo A, Yin Z, Paul JS) J Trauma Acute Care Surg 2019 Feb;86(2):181-188 PMID: 30376537 SCOPUS ID: 2-s2.0-85060819442 10/31/2018       39 Citations
  • Pharmacological considerations in acute and chronic liver disease (Peppard WJ, Killian AJ, Biesboer AN) Hepatic Critical Care 8 January 2018:211-232 SCOPUS ID: 2-s2.0-85054950262 01/08/2018    
  • Pharmacist involvement on a rapid response team. (Feih J, Peppard WJ, Katz M) Am J Health Syst Pharm 2017 Mar 01;74(5 Supplement 1):S10-S16 PMID: 28213382 SCOPUS ID: 2-s2.0-85032283255 02/19/2017       15 Citations
  • Association between Pre-Operative Cefazolin Dose and Surgical Site Infection in Obese Patients. (Peppard WJ, Eberle DG, Kugler NW, Mabrey DM, Weigelt JA) Surg Infect (Larchmt) 2017;18(4):485-490 PMID: 27906601 PMCID: PMC5466014 SCOPUS ID: 2-s2.0-85019715220 12/03/2016       20 Citations
  • New developments in the treatment of acute bacterial skin and skin structure infections: considerations for the effective use of dalbavancin. (Juul JJ, Mullins CF, Peppard WJ, Huang AM) Ther Clin Risk Manag 2016;12:225-32 PMID: 26937194 PMCID: PMC4762434 SCOPUS ID: 2-s2.0-84958550560 03/05/2016       12 Citations
  • Implementation of Polymerase Chain Reaction to Rule Out Clostridium difficile Infection Is Associated With Reduced Empiric Antibiotic Duration of Therapy. (Peppard WJ, Ledeboer NA) Hosp Pharm 2014 Jul;49(7):639-43 PMID: 25477583 PMCID: PMC4252234 SCOPUS ID: 2-s2.0-84905395475 12/06/2014       8 Citations
  • Early Trophic Enteral Nutrition Is Associated With Improved Outcomes in Mechanically Ventilated Patients With Septic Shock: A Retrospective Review. (Patel JJ, Kozeniecki M, Biesboer A, Peppard W, Ray AS, Thomas S, Jacobs ER, Nanchal R, Kumar G) J Intensive Care Med 2016 Aug;31(7):471-7 PMID: 25315218 SCOPUS ID: 2-s2.0-84978069680 10/16/2014       46 Citations
  • Photo quiz: a 5-year-old male with multiple pustules covering the entire scalp. Inflammatory Tinea Capitis. (Feih J, Ledeboer NA, Peppard WJ) J Clin Microbiol 2014 Apr;52(4):1027, 1312 PMID: 24619982 PMCID: PMC3993504 SCOPUS ID: 2-s2.0-84897149340 03/13/2014       1 Citation
  • Phenytoin removal by continuous venovenous hemofiltration. (Oltrogge KM, Peppard WJ, Saleh M, Regner KR, Herrmann DJ) Ann Pharmacother 2013 Sep;47(9):1218-22 PMID: 24259740 SCOPUS ID: 2-s2.0-84884491746 11/22/2013       14 Citations
  • Optimizing drug therapy in the surgical intensive care unit. (Peppard WJ, Peppard SR, Somberg L) Surg Clin North Am 2012 Dec;92(6):1573-620 PMID: 23153885 SCOPUS ID: 2-s2.0-84869127744 11/17/2012       2 Citations
  • Safety and efficacy of prophylactic anticoagulation in patients with traumatic brain injury. (Scudday T, Brasel K, Webb T, Codner P, Somberg L, Weigelt J, Herrmann D, Peppard W) J Am Coll Surg 2011 Jul;213(1):148-53; discussion 153-4 PMID: 21459632 SCOPUS ID: 2-s2.0-79959503385 04/05/2011       95 Citations
  • Role of telavancin in treatment of skin and skin structure infections. (Bonkowski J, Daniels AR, Peppard WJ) Clin Cosmet Investig Dermatol 2010 Oct 07;3:127-33 PMID: 21437067 PMCID: PMC3047943 01/01/2010    
  • Evidence based approach to the treatment of community-associated methicillin-resistant Staphylococcus aureus. (Peppard WJ, Daniels A, Fehrenbacher L, Winner J) Infect Drug Resist 2009;2:27-40 PMID: 21694885 PMCID: PMC3108727 SCOPUS ID: 2-s2.0-77953384850 01/01/2009       6 Citations
  • Evidence based approach to the treatment of community-associated methicillin-resistant Staphylococcus aureus (Peppard WJ, Daniels A, Fehrenbacher L, Winner J) Infection and Drug Resistance 2009;2(1):27-40 SCOPUS ID: 2-s2.0-77953384850 01/01/2009       6 Citations
  • Linezolid for the treatment of drug-resistant infections. (Herrmann DJ, Peppard WJ, Ledeboer NA, Theesfeld ML, Weigelt JA, Buechel BJ) Expert Rev Anti Infect Ther 2008 Dec;6(6):825-48 PMID: 19053895 SCOPUS ID: 2-s2.0-59449100218 12/05/2008       29 Citations
  • Pharmacologic options for CNS infections caused by resistant Gram-positive organisms. (Peppard WJ, Johnston CJ, Urmanski AM) Expert Rev Anti Infect Ther 2008 Feb;6(1):83-99 PMID: 18251666 SCOPUS ID: 2-s2.0-40649123588 02/07/2008       15 Citations
  • Iclaprim, a diaminopyrimidine dihydrofolate reductase inhibitor for the potential treatment of antibiotic-resistant staphylococcal infections. (Peppard WJ, Schuenke CD) Curr Opin Investig Drugs 2008 Feb;9(2):210-25 PMID: 18246524 SCOPUS ID: 2-s2.0-38849190721 02/05/2008       35 Citations
  • Clostridium difficile enteritis: an early postoperative complication in inflammatory bowel disease patients after colectomy. (Lundeen SJ, Otterson MF, Binion DG, Carman ET, Peppard WJ) J Gastrointest Surg 2007 Feb;11(2):138-42 PMID: 17390162 SCOPUS ID: 2-s2.0-34548442485 03/29/2007       72 Citations
  • Role of linezolid in the treatment of complicated skin and soft tissue infections. (Peppard WJ, Weigelt JA) Expert Rev Anti Infect Ther 2006 Jun;4(3):357-66 PMID: 16771613 SCOPUS ID: 2-s2.0-33745214003 06/15/2006       21 Citations
    • Last update: 12/27/2023