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Xue-Zhong Yu MD

Xue-Zhong Yu MD profile photo picture

Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology
Program: Core Facilities

Member of the Cancer Center
Member of the Center for Immunology


Research Areas of Interest

  • Adoptive Transfer
  • Graft vs Host Disease
  • Graft vs Leukemia Effect
  • Immunotherapy
  • T-Lymphocytes
  • Research Experience

  • Bone Marrow Transplantation
  • Cell Differentiation
  • Cell Proliferation
  • Disease Models, Animal
  • Hematopoietic Stem Cell Transplantation
  • Lymphocyte Activation
  • T-Lymphocytes, Regulatory
  • Xenograft Model Antitumor Assays
  • Leadership Positions

  • Associate Director in Basic Sciences, the Cancer Center
  • MCW Program / Core Facilities

  • Center for Immunology
  • Cancer Center
  • Publications (99)

  • MicroRNA-31 regulates T-cell metabolism via HIF1α and promotes chronic GVHD pathogenesis in mice. (Wu Y, Mealer C, Schutt S, Wilson CL, Bastian D, Sofi MH, Zhang M, Luo Z, Choi HJ, Yang K, Tian L, Nguyen H, Helke K, Schnapp LM, Wang H, Yu XZ) Blood Adv 2022 05 24;6(10):3036-3052 PMID: 35073581 01/25/2022    
  • Donor T-Cell Repertoire Profiling in Recipient Lymphoid and Parenchyma Organs Reveals GVHD Pathogenesis at Clonal Levels After Bone Marrow Transplantation in Mice. (Wu Y, Fu J, Wang H, Yu XZ) Front Immunol 2021;12:778996 PMID: 34950143 PMCID: PMC8688739 SCOPUS ID: 2-s2.0-85121630632 12/25/2021    
  • XBP-1s Promotes B Cell Pathogenicity in Chronic GVHD by Restraining the Activity of Regulated IRE-1α-Dependent Decay. (Choi HJ, Tang CA, Tian L, Wu Y, Sofi MH, Ticer T, Schutt SD, Hu CA, Yu XZ) Front Immunol 2021;12:705484 PMID: 34659198 PMCID: PMC8517405 SCOPUS ID: 2-s2.0-85117251520 10/19/2021    
  • Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia. (Gao X, Qin S, Wu Y, Chu C, Jiang B, Johnson RH, Kuang D, Zhang J, Wang X, Mehta A, Tew KD, Leone GW, Yu XZ, Wang H) J Clin Invest 2021 08 16;131(16) PMID: 34255748 PMCID: PMC8363288 SCOPUS ID: 2-s2.0-85113146308 07/14/2021       4 Citations
  • Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response. (Vaena S, Chakraborty P, Lee HG, Janneh AH, Kassir MF, Beeson G, Hedley Z, Yalcinkaya A, Sofi MH, Li H, Husby ML, Stahelin RV, Yu XZ, Mehrotra S, Ogretmen B) Cell Rep 2021 05 04;35(5):109076 PMID: 33951438 PMCID: PMC8127241 SCOPUS ID: 2-s2.0-85105099130 05/06/2021       4 Citations
  • Interleukin-23 receptor signaling by interleukin-39 potentiates T cell pathogenicity in acute graft-versus-host disease. (Bastian D, Sui X, Nguyen HD, Wu Y, Schutt S, Tian L, Sofi MH, Liu Y, Martin P, Bartee E, Yu XZ) Am J Transplant 2021 11;21(11):3538-3549 PMID: 33934505 SCOPUS ID: 2-s2.0-85107315823 05/03/2021       4 Citations
  • A single strain of Bacteroides fragilis protects gut integrity and reduces GVHD. (Sofi MH, Wu Y, Ticer T, Schutt S, Bastian D, Choi HJ, Tian L, Mealer C, Liu C, Westwater C, Armeson KE, Alekseyenko AV, Yu XZ) JCI Insight 2021 02 08;6(3) PMID: 33554953 PMCID: PMC7934839 SCOPUS ID: 2-s2.0-85101018758 02/09/2021       12 Citations
  • STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function. (Wu Y, Tang CA, Mealer C, Bastian D, Hanief Sofi M, Tian L, Schutt S, Choi HJ, Ticer T, Zhang M, Sui X, Huang L, Mellor AL, Hu CA, Yu XZ) Cell Mol Immunol 2021 03;18(3):632-643 PMID: 33500563 PMCID: PMC8027033 SCOPUS ID: 2-s2.0-85099750259 01/28/2021    
  • Expression of GM-CSF Is Regulated by Fli-1 Transcription Factor, a Potential Drug Target. (Wang X, Lennard Richard M, Li P, Henry B, Schutt S, Yu XZ, Fan H, Zhang W, Gilkeson G, Zhang XK) J Immunol 2021 01 01;206(1):59-66 PMID: 33268481 PMCID: PMC7942804 SCOPUS ID: 2-s2.0-85098732896 12/04/2020       3 Citations
  • Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease. (Nguyen HD, Ticer T, Bastian D, Kuril S, Li H, Du H, Yan C, Yu XZ) Cell Rep 2020 10 27;33(4):108316 PMID: 33113360 PMCID: PMC7706352 SCOPUS ID: 2-s2.0-85094605461 10/29/2020       3 Citations
  • Clarifying the translational potential of B-I09. (Del Valle JR, Betts BC, Yu XZ, Janssens S, Lambrecht BN, Simon MC, Hu CA) Nat Chem Biol 2020 11;16(11):1152 PMID: 33067597 PMCID: PMC7610990 SCOPUS ID: 2-s2.0-85092552469 10/18/2020       1 Citation
  • RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity. (Ansa-Addo EA, Huang HC, Riesenberg B, Iamsawat S, Borucki D, Nelson MH, Nam JH, Chung D, Paulos CM, Liu B, Yu XZ, Philpott C, Howe PH, Li Z) Sci Adv 2020 05;6(22):eaaz3865 PMID: 32523987 PMCID: PMC7259945 SCOPUS ID: 2-s2.0-85086355972 06/12/2020       11 Citations
  • Cereblon harnesses Myc-dependent bioenergetics and activity of CD8+ T lymphocytes. (Hesterberg RS, Beatty MS, Han Y, Fernandez MR, Akuffo AA, Goodheart WE, Yang C, Chang S, Colin CM, Alontaga AY, McDaniel JM, Mailloux AW, Billington JMR, Yue L, Russell S, Gillies RJ, Yun SY, Ayaz M, Lawrence NJ, Lawrence HR, Yu XZ, Fu J, Darville LN, Koomen JM, Ren X, Messina J, Jiang K, Garrett TJ, Rajadhyaksha AM, Cleveland JL, Epling-Burnette PK) Blood 2020 08 13;136(7):857-870 PMID: 32403132 PMCID: PMC7426646 SCOPUS ID: 2-s2.0-85089616445 05/14/2020       9 Citations
  • Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease. (Nguyen H, Alawieh A, Bastian D, Kuril S, Dai M, Daenthanasanmak A, Zhang M, Iamsawat S, Schutt SD, Wu Y, Sleiman MM, Shetty A, Atkinson C, Sun S, Varela JC, Tomlinson S, Yu XZ) Clin Cancer Res 2020 07 01;26(13):3481-3490 PMID: 31919135 PMCID: PMC7334060 SCOPUS ID: 2-s2.0-85087469837 01/11/2020       3 Citations
  • Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse. (Iamsawat S, Tian L, Daenthanasanmak A, Wu Y, Nguyen HD, Bastian D, Yu XZ) Blood Adv 2019 12 23;3(24):4187-4201 PMID: 31856270 PMCID: PMC6929397 SCOPUS ID: 2-s2.0-85077917688 12/20/2019       8 Citations
  • Editorial: Pathogenesis and Therapy of Graft-versus-Host Disease. (Betts BC, Yu XZ) Front Immunol 2019;10:1797 PMID: 31417565 PMCID: PMC6685138 SCOPUS ID: 2-s2.0-85069540206 08/17/2019       2 Citations
  • Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity. (Chakraborty P, Vaena SG, Thyagarajan K, Chatterjee S, Al-Khami A, Selvam SP, Nguyen H, Kang I, Wyatt MW, Baliga U, Hedley Z, Ngang RN, Guo B, Beeson GC, Husain S, Paulos CM, Beeson CC, Zilliox MJ, Hill EG, Mehrotra M, Yu XZ, Ogretmen B, Mehrotra S) Cell Rep 2019 08 13;28(7):1879-1893.e7 PMID: 31412253 PMCID: PMC6889821 SCOPUS ID: 2-s2.0-85071280128 08/15/2019       33 Citations
  • The IL-12 Cytokine and Receptor Family in Graft-vs.-Host Disease. (Bastian D, Wu Y, Betts BC, Yu XZ) Front Immunol 2019;10:988 PMID: 31139181 PMCID: PMC6518430 SCOPUS ID: 2-s2.0-85067295445 05/30/2019       23 Citations
  • Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease. (Sofi MH, Wu Y, Schutt SD, Dai M, Daenthanasanmak A, Heinrichs Voss J, Nguyen H, Bastian D, Iamsawat S, Selvam SP, Liu C, Maulik N, Ogretmen B, Jin J, Mehrotra S, Yu XZ) J Clin Invest 2019 05 02;129(7):2760-2774 PMID: 31045571 PMCID: PMC6597211 SCOPUS ID: 2-s2.0-85068520003 05/03/2019       12 Citations
  • Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells. (Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball L, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S) J Biol Chem 2019 06 07;294(23):9198-9212 PMID: 30971427 PMCID: PMC6556575 SCOPUS ID: 2-s2.0-85066952072 04/12/2019       13 Citations
  • Modelling CAR-T therapy in humanized mice. (Wu Y, Yu XZ) EBioMedicine 2019 Feb;40:25-26 PMID: 30665855 PMCID: PMC6413350 SCOPUS ID: 2-s2.0-85060100966 01/23/2019       3 Citations
  • Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells. (Nguyen H, Kuril S, Bastian D, Kim J, Zhang M, Vaena SG, Dany M, Dai M, Heinrichs JL, Daenthanasanmak A, Iamsawat S, Schutt S, Fu J, Wu Y, Fairlie DP, Atkinson C, Ogretmen B, Tomlinson S, Yu XZ) JCI Insight 2018 12 20;3(24) PMID: 30568037 PMCID: PMC6338312 SCOPUS ID: 2-s2.0-85063246991 12/21/2018       13 Citations
  • Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice. (Daenthanasanmak A, Iamsawat S, Chakraborty P, Nguyen HD, Bastian D, Liu C, Mehrotra S, Yu XZ) Blood 2019 01 17;133(3):266-279 PMID: 30514750 PMCID: PMC6337874 SCOPUS ID: 2-s2.0-85059529820 12/06/2018       38 Citations
  • Targeting PIM Kinase with PD1 Inhibition Improves Immunotherapeutic Antitumor T-cell Response. (Chatterjee S, Chakraborty P, Daenthanasanmak A, Iamsawat S, Andrejeva G, Luevano LA, Wolf M, Baliga U, Krieg C, Beeson CC, Mehrotra M, Hill EG, Rathmell JC, Yu XZ, Kraft AS, Mehrotra S) Clin Cancer Res 2019 02 01;25(3):1036-1049 PMID: 30327305 PMCID: PMC6361669 SCOPUS ID: 2-s2.0-85060939181 10/18/2018       22 Citations
  • Stabilization of Foxp3 by Targeting JAK2 Enhances Efficacy of CD8 Induced Regulatory T Cells in the Prevention of Graft-versus-Host Disease. (Iamsawat S, Daenthanasanmak A, Voss JH, Nguyen H, Bastian D, Liu C, Yu XZ) J Immunol 2018 11 01;201(9):2812-2823 PMID: 30242073 PMCID: PMC6200641 SCOPUS ID: 2-s2.0-85055172850 09/23/2018       17 Citations
  • Inducible T-Cell Co-Stimulator Impacts Chronic Graft-Versus-Host Disease by Regulating Both Pathogenic and Regulatory T Cells. (Zhang M, Wu Y, Bastian D, Iamsawat S, Chang J, Daenthanasanmak A, Nguyen HD, Schutt S, Dai M, Chen F, Suh WK, Yu XZ) Front Immunol 2018;9:1461 PMID: 29988391 PMCID: PMC6023972 SCOPUS ID: 2-s2.0-85048926363 07/11/2018       12 Citations
  • PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. (Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen HD, Bastian D, Zhang M, Sofi MH, Chatterjee S, Hill EG, Mehrotra S, Kraft AS, Yu XZ) J Clin Invest 2018 07 02;128(7):2787-2801 PMID: 29781812 PMCID: PMC6025986 SCOPUS ID: 2-s2.0-85049843113 05/22/2018       13 Citations
  • MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice. (Wu Y, Schutt S, Paz K, Zhang M, Flynn RP, Bastian D, Sofi MH, Nguyen H, Dai M, Liu C, Chang YJ, Blazar BR, Yu XZ) Blood 2018 04 26;131(17):1974-1986 PMID: 29530952 PMCID: PMC5921962 SCOPUS ID: 2-s2.0-85047856364 03/14/2018       28 Citations
  • Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice. (Schutt SD, Wu Y, Tang CH, Bastian D, Nguyen H, Sofi MH, Zhang M, Liu C, Helke K, Wilson C, Schnapp LM, Del Valle JR, Hu CC, Yu XZ) Blood Adv 2018 02 27;2(4):414-427 PMID: 29483082 PMCID: PMC5858472 SCOPUS ID: 2-s2.0-85060136813 02/28/2018       14 Citations
  • T-Cell Metabolism in Hematopoietic Cell Transplantation. (Nguyen HD, Kuril S, Bastian D, Yu XZ) Front Immunol 2018;9:176 PMID: 29479351 PMCID: PMC5811499 SCOPUS ID: 2-s2.0-85041801318 02/27/2018       17 Citations
  • Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. (Betts BC, Bastian D, Iamsawat S, Nguyen H, Heinrichs JL, Wu Y, Daenthanasanmak A, Veerapathran A, O'Mahony A, Walton K, Reff J, Horna P, Sagatys EM, Lee MC, Singer J, Chang YJ, Liu C, Pidala J, Anasetti C, Yu XZ) Proc Natl Acad Sci U S A 2018 02 13;115(7):1582-1587 PMID: 29382747 PMCID: PMC5816153 SCOPUS ID: 2-s2.0-85042003500 02/01/2018       40 Citations
  • IL-27 Receptor Signaling on T cells Augments GVHD Severity through Enhancing Th1 Responses. (Bastian D, Liu Y, Wu Y, Schutt S, Nguyen HD, Daenthanasanmak A, Sofi MH, Zhang M, Iamsuwat S, Yu XZ) J Immunol Res Ther 2018;3(1):151-157 PMID: 30906912 PMCID: PMC6426137 01/01/2018    
  • CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. (Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt MW, Dhar P, Selvam SP, Fu J, Zhang J, Nguyen H, Kang I, Toth K, Al-Homrani M, Husain M, Beeson G, Ball L, Helke K, Husain S, Garrett-Mayer E, Hardiman G, Mehrotra M, Nishimura MI, Beeson CC, Bupp MG, Wu J, Ogretmen B, Paulos CM, Rathmell J, Yu XZ, Mehrotra S) Cell Metab 2018 01 09;27(1):85-100.e8 PMID: 29129787 PMCID: PMC5837048 SCOPUS ID: 2-s2.0-85033367546 11/14/2017       105 Citations
  • T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. (Woods DM, Woan KV, Cheng F, Sodré AL, Wang D, Wu Y, Wang Z, Chen J, Powers J, Pinilla-Ibarz J, Yu Y, Zhang Y, Wu X, Zheng X, Weber J, Hancock WW, Seto E, Villagra A, Yu XZ, Sotomayor EM) Blood 2017 07 13;130(2):146-155 PMID: 28550044 PMCID: PMC5510785 SCOPUS ID: 2-s2.0-85023757456 05/28/2017       38 Citations
  • Ceramide synthesis regulates T cell activity and GVHD development. (Sofi MH, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, Schutt S, Wu Y, Daenthanasanmak A, Gencer S, Zivkovic A, Szulc Z, Stark H, Liu C, Chang YJ, Ogretmen B, Yu XZ) JCI Insight 2017 May 18;2(10) PMID: 28515365 PMCID: PMC5436544 SCOPUS ID: 2-s2.0-85099809147 05/19/2017       5 Citations
  • Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset. (Padi SKR, Luevano LA, An N, Pandey R, Singh N, Song JH, Aster JC, Yu XZ, Mehrotra S, Kraft AS) Oncotarget 2017 May 02;8(18):30199-30216 PMID: 28415816 PMCID: PMC5444737 SCOPUS ID: 2-s2.0-85018997702 04/19/2017       25 Citations
  • Regulatory B cells promote graft-versus-host disease prevention and maintain graft-versus-leukemia activity following allogeneic bone marrow transplantation. (Hu Y, He GL, Zhao XY, Zhao XS, Wang Y, Xu LP, Zhang XH, Yu XZ, Liu KY, Chang YJ, Huang XJ) Oncoimmunology 2017;6(3):e1284721 PMID: 28405514 PMCID: PMC5384367 SCOPUS ID: 2-s2.0-85015225488 04/14/2017       21 Citations
  • Lower incidence of acute GVHD is associated with the rapid recovery of CD4+CD25+CD45RA+ regulatory T cells in patients who received haploidentical allografts from NIMA-mismatched donors: A retrospective (development) and prospective (validation) cohort-based study. (Wang Y, Zhao XY, Xu LP, Zhang XH, Han W, Chen H, Wang FR, Mo XD, Zhang YY, Zhao XS, Y K, Liua KY, Huang XJ, Yu XZ, Chang YJ) Oncoimmunology 2016;5(12):e1242546 PMID: 28180031 PMCID: PMC5215191 SCOPUS ID: 2-s2.0-85007429427 02/10/2017       10 Citations
  • Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice. (Bartee E, Bartee MY, Bogen B, Yu XZ) Mol Ther Oncolytics 2016;3:16032 PMID: 27933316 PMCID: PMC5142464 SCOPUS ID: 2-s2.0-85006057076 12/10/2016       23 Citations
  • IL-17A ≠ Th17 in GvHD. (Wu Y, Yu XZ) Cell Mol Immunol 2018 03;15(3):282-283 PMID: 27796285 PMCID: PMC5843611 SCOPUS ID: 2-s2.0-85042920910 11/01/2016    
  • Regulatory T-Cell Therapy for Graft-versus-host Disease. (Heinrichs J, Bastian D, Veerapathran A, Anasetti C, Betts B, Yu XZ) J Immunol Res Ther 2016;1(1):1-14 PMID: 27722210 PMCID: PMC5049884 10/11/2016    
  • CD8(+) Tregs promote GVHD prevention and overcome the impaired GVL effect mediated by CD4(+) Tregs in mice. (Heinrichs J, Li J, Nguyen H, Wu Y, Bastian D, Daethanasanmak A, Sofi MH, Schutt S, Liu C, Jin J, Betts B, Anasetti C, Yu XZ) Oncoimmunology 2016 Jun;5(6):e1146842 PMID: 27471614 PMCID: PMC4938369 SCOPUS ID: 2-s2.0-84969706587 07/30/2016       35 Citations
  • Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation. (Nguyen HD, Chatterjee S, Haarberg KM, Wu Y, Bastian D, Heinrichs J, Fu J, Daenthanasanmak A, Schutt S, Shrestha S, Liu C, Wang H, Chi H, Mehrotra S, Yu XZ) J Clin Invest 2016 Apr 01;126(4):1337-52 PMID: 26950421 PMCID: PMC4811142 SCOPUS ID: 2-s2.0-84964600705 03/08/2016       71 Citations
  • T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. (Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ) J Immunol 2016 Apr 01;196(7):3168-79 PMID: 26903480 PMCID: PMC4799777 SCOPUS ID: 2-s2.0-84962523010 02/24/2016       2 Citations
  • Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic. (Majchrzak K, Nelson MH, Bailey SR, Bowers JS, Yu XZ, Rubinstein MP, Himes RA, Paulos CM) Cancer Immunol Immunother 2016 Mar;65(3):247-59 PMID: 26825102 PMCID: PMC5115162 SCOPUS ID: 2-s2.0-84959481142 01/31/2016       24 Citations
  • A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma. (Zhu P, Jin J, Liao Y, Li J, Yu XZ, Liao W, He S) Oncotarget 2015 Dec 01;6(38):41383-97 PMID: 26515591 PMCID: PMC4747413 SCOPUS ID: 2-s2.0-84951060810 10/31/2015       24 Citations
  • Inhibition of BTK and ITK with Ibrutinib Is Effective in the Prevention of Chronic Graft-versus-Host Disease in Mice. (Schutt SD, Fu J, Nguyen H, Bastian D, Heinrichs J, Wu Y, Liu C, McDonald DG, Pidala J, Yu XZ) PLoS One 2015;10(9):e0137641 PMID: 26348529 PMCID: PMC4562702 SCOPUS ID: 2-s2.0-84945231899 09/09/2015       62 Citations
  • MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3. (Zhang L, Ke F, Liu Z, Bai J, Liu J, Yan S, Xu Z, Lou F, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Li Q, Yu XZ, Qian Y, Hua Z, Deng J, Li QJ, Wang H) Nat Commun 2015 Jul 13;6:7639 PMID: 26165721 PMCID: PMC4510656 SCOPUS ID: 2-s2.0-84954193320 07/15/2015       63 Citations
  • MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice. (Wu Y, Heinrichs J, Bastian D, Fu J, Nguyen H, Schutt S, Liu Y, Jin J, Liu C, Li QJ, Xia C, Yu XZ) Blood 2015 Sep 10;126(11):1314-23 PMID: 26138686 PMCID: PMC4566810 SCOPUS ID: 2-s2.0-84942512521 07/04/2015       40 Citations
  • NF-κB-induced microRNA-31 promotes epidermal hyperplasia by repressing protein phosphatase 6 in psoriasis. (Yan S, Xu Z, Lou F, Zhang L, Ke F, Bai J, Liu Z, Liu J, Wang H, Zhu H, Sun Y, Cai W, Gao Y, Su B, Li Q, Yang X, Yu J, Lai Y, Yu XZ, Zheng Y, Shen N, Chin YE, Wang H) Nat Commun 2015 Jul 03;6:7652 PMID: 26138368 PMCID: PMC4506511 SCOPUS ID: 2-s2.0-84936791909 07/04/2015       140 Citations
  • HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease. (Li J, Heinrichs J, Haarberg K, Semple K, Veerapathran A, Liu C, Anasetti C, Yu XZ) J Immunol 2015 Jul 15;195(2):717-25 PMID: 26048147 PMCID: PMC4491008 SCOPUS ID: 2-s2.0-84936762835 06/07/2015       15 Citations
  • Essential Role of Interleukin-12/23p40 in the Development of Graft-versus-Host Disease in Mice. (Wu Y, Bastian D, Schutt S, Nguyen H, Fu J, Heinrichs J, Xia C, Yu XZ) Biol Blood Marrow Transplant 2015 Jul;21(7):1195-204 PMID: 25846718 PMCID: PMC4466028 SCOPUS ID: 2-s2.0-84930576723 04/08/2015       20 Citations
  • T-bet is critical for the development of acute graft-versus-host disease through controlling T cell differentiation and function. (Fu J, Wang D, Yu Y, Heinrichs J, Wu Y, Schutt S, Kaosaard K, Liu C, Haarberg K, Bastian D, McDonald DG, Anasetti C, Yu XZ) J Immunol 2015 Jan 01;194(1):388-97 PMID: 25404360 PMCID: PMC4314960 SCOPUS ID: 2-s2.0-84919663260 11/19/2014       24 Citations
  • NF-κB is crucial in proximal T-cell signaling for calcium influx and NFAT activation. (Bronk CC, Yoder S, Hopewell EL, Yang S, Celis E, Yu XZ, Beg AA) Eur J Immunol 2014 Dec;44(12):3741-6 PMID: 25251667 PMCID: PMC4261047 SCOPUS ID: 2-s2.0-84924322584 09/25/2014       8 Citations
  • Reducing CD73 expression by IL1β-Programmed Th17 cells improves immunotherapeutic control of tumors. (Chatterjee S, Thyagarajan K, Kesarwani P, Song JH, Soloshchenko M, Fu J, Bailey SR, Vasu C, Kraft AS, Paulos CM, Yu XZ, Mehrotra S) Cancer Res 2014 Nov 01;74(21):6048-59 PMID: 25205101 PMCID: PMC4216762 SCOPUS ID: 2-s2.0-84909606726 09/11/2014       35 Citations
  • Helper T-cell differentiation in graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (Fu J, Heinrichs J, Yu XZ) Arch Immunol Ther Exp (Warsz) 2014 Aug;62(4):277-301 PMID: 24699629 SCOPUS ID: 2-s2.0-84904287693 04/05/2014       19 Citations
  • Tolerance induction between two different strains of parental mice prevents graft-versus-host disease in haploidentical hematopoietic stem cell transplantation to F1 mice. (Guo Y, Zhang L, Wan S, Sun X, Wu Y, Yu XZ, Xia CQ) Biochem Biophys Res Commun 2014 Apr 18;446(4):1035-41 PMID: 24661874 SCOPUS ID: 2-s2.0-84899490787 03/26/2014       2 Citations
  • STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity. (Betts BC, Veerapathran A, Pidala J, Yu XZ, Anasetti C) J Leukoc Biol 2014 Feb;95(2):205-13 PMID: 24068731 PMCID: PMC3896660 SCOPUS ID: 2-s2.0-84897026776 09/27/2013       27 Citations
  • Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. (Haarberg KM, Li J, Heinrichs J, Wang D, Liu C, Bronk CC, Kaosaard K, Owyang AM, Holland S, Masuda E, Tso K, Blazar BR, Anasetti C, Beg AA, Yu XZ) Blood 2013 Oct 03;122(14):2500-11 PMID: 23908466 PMCID: PMC3790515 SCOPUS ID: 2-s2.0-84887761550 08/03/2013       34 Citations
  • Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease. (Veerapathran A, Pidala J, Beato F, Betts B, Kim J, Turner JG, Hellerstein MK, Yu XZ, Janssen W, Anasetti C) Blood 2013 Sep 26;122(13):2251-61 PMID: 23908471 PMCID: PMC3785121 SCOPUS ID: 2-s2.0-84887347546 08/03/2013       34 Citations
  • Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. (Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, Gigoux M, Kornete M, Piccirillo CA, Suh WK, Yu XZ) J Immunol 2013 Jul 01;191(1):200-7 PMID: 23729441 PMCID: PMC4318500 SCOPUS ID: 2-s2.0-84879659016 06/05/2013       19 Citations
  • c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice. (Yu Y, Wang D, Kaosaard K, Liu C, Fu J, Haarberg K, Anasetti C, Beg AA, Yu XZ) Eur J Immunol 2013 Sep;43(9):2327-37 PMID: 23716202 PMCID: PMC3940138 SCOPUS ID: 2-s2.0-84883519965 05/30/2013       18 Citations
  • Dynamic change and impact of myeloid-derived suppressor cells in allogeneic bone marrow transplantation in mice. (Wang D, Yu Y, Haarberg K, Fu J, Kaosaard K, Nagaraj S, Anasetti C, Gabrilovich D, Yu XZ) Biol Blood Marrow Transplant 2013 May;19(5):692-702 PMID: 23376089 PMCID: PMC4011929 SCOPUS ID: 2-s2.0-84876344072 02/05/2013       52 Citations
  • Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms. (Yu Y, Cho HI, Wang D, Kaosaard K, Anasetti C, Celis E, Yu XZ) J Immunol 2013 Feb 15;190(4):1873-81 PMID: 23315072 PMCID: PMC3563723 SCOPUS ID: 2-s2.0-84873534440 01/15/2013       49 Citations
  • Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential. (Bronk CC, Yu XZ, Beg AA) Front Immunol 2012;3:259 PMID: 22912640 PMCID: PMC3418525 SCOPUS ID: 2-s2.0-84874221354 08/23/2012       5 Citations
  • LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice. (Wang D, Iclozan C, Liu C, Xia C, Anasetti C, Yu XZ) Biol Blood Marrow Transplant 2012 Aug;18(8):1182-1190.e1 PMID: 22698484 PMCID: PMC3417119 SCOPUS ID: 2-s2.0-84864020953 06/16/2012       23 Citations
  • Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo. (Yu Y, Yu J, Iclozan C, Kaosaard K, Anasetti C, Yu XZ) Am J Blood Res 2012;2(1):77-85 PMID: 22432091 PMCID: PMC3301434 03/21/2012    
  • Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly. (Veerapathran A, Pidala J, Beato F, Yu XZ, Anasetti C) Blood 2011 Nov 17;118(20):5671-80 PMID: 21948174 PMCID: PMC3217366 SCOPUS ID: 2-s2.0-81555214616 09/29/2011       98 Citations
  • Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice. (Yu Y, Wang D, Liu C, Kaosaard K, Semple K, Anasetti C, Yu XZ) Blood 2011 Nov 03;118(18):5011-20 PMID: 21856864 PMCID: PMC3208306 SCOPUS ID: 2-s2.0-80855128779 08/23/2011       113 Citations
  • Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice. (Li J, Semple K, Suh WK, Liu C, Chen F, Blazar BR, Yu XZ) Biol Blood Marrow Transplant 2011 Jul;17(7):962-9 PMID: 21447398 PMCID: PMC3131782 SCOPUS ID: 2-s2.0-79958742892 03/31/2011       35 Citations
  • Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice. (Li Q, Ke F, Zhang W, Shen X, Xu Q, Wang H, Yu XZ, Leng Q, Wang H) PLoS One 2011 Feb 02;6(2):e16483 PMID: 21311769 PMCID: PMC3032787 SCOPUS ID: 2-s2.0-79551642928 02/12/2011       26 Citations
  • Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling. (Semple K, Nguyen A, Yu Y, Wang H, Anasetti C, Yu XZ) Blood 2011 Mar 17;117(11):3096-103 PMID: 21245484 PMCID: PMC3062312 SCOPUS ID: 2-s2.0-79953073879 01/20/2011       66 Citations
  • Efficient and selective prevention of GVHD by antigen-specific induced Tregs via linked-suppression in mice. (Semple K, Yu Y, Wang D, Anasetti C, Yu XZ) Biol Blood Marrow Transplant 2011 Mar;17(3):309-18 PMID: 21224010 PMCID: PMC3039088 SCOPUS ID: 2-s2.0-79551678785 01/13/2011       35 Citations
  • PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. (Valenzuela JO, Iclozan C, Hossain MS, Prlic M, Hopewell E, Bronk CC, Wang J, Celis E, Engelman RW, Blazar BR, Bevan MJ, Waller EK, Yu XZ, Beg AA) J Clin Invest 2009 Dec;119(12):3774-86 PMID: 19907075 PMCID: PMC2786796 SCOPUS ID: 2-s2.0-72849123229 11/13/2009       63 Citations
  • T helper17 cells are sufficient but not necessary to induce acute graft-versus-host disease. (Iclozan C, Yu Y, Liu C, Liang Y, Yi T, Anasetti C, Yu XZ) Biol Blood Marrow Transplant 2010 Feb;16(2):170-8 PMID: 19804837 PMCID: PMC3876952 SCOPUS ID: 2-s2.0-75149118145 10/07/2009       82 Citations
  • Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death. (Yu Y, Iclozan C, Yamazaki T, Yang X, Anasetti C, Dong C, Yu XZ) Blood 2009 Jul 30;114(5):1026-8 PMID: 19429865 PMCID: PMC2721783 SCOPUS ID: 2-s2.0-70349229827 05/12/2009       30 Citations
  • Ethylenecarbodiimide-coupled allogeneic antigen presenting cells induce human CD4+ regulatory T cells. (Albert MH, Yu XZ, Magg T) Clin Immunol 2008 Dec;129(3):381-93 PMID: 18819845 PMCID: PMC3033601 SCOPUS ID: 2-s2.0-55549130238 09/30/2008       2 Citations
  • CD28 controls differentiation of regulatory T cells from naive CD4 T cells. (Guo F, Iclozan C, Suh WK, Anasetti C, Yu XZ) J Immunol 2008 Aug 15;181(4):2285-91 PMID: 18684917 PMCID: PMC2688779 SCOPUS ID: 2-s2.0-53149114893 08/08/2008       85 Citations
  • TGF-beta-dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis. (Wang H, Peters T, Sindrilaru A, Kess D, Oreshkova T, Yu XZ, Seier AM, Schreiber H, Wlaschek M, Blakytny R, Röhrbein J, Schulz G, Weiss JM, Scharffetter-Kochanek K) J Clin Invest 2008 Jul;118(7):2629-39 PMID: 18521187 PMCID: PMC2398739 SCOPUS ID: 2-s2.0-46749143803 06/04/2008       52 Citations
  • Beta2 integrins separate graft-versus-host disease and graft-versus-leukemia effects. (Liang Y, Liu C, Djeu JY, Zhong B, Peters T, Scharffetter-Kochanek K, Anasetti C, Yu XZ) Blood 2008 Jan 15;111(2):954-62 PMID: 17928532 PMCID: PMC2200850 SCOPUS ID: 2-s2.0-38349188886 10/12/2007       42 Citations
  • Opposing effects of ICOS on graft-versus-host disease mediated by CD4 and CD8 T cells. (Yu XZ, Liang Y, Nurieva RI, Guo F, Anasetti C, Dong C) J Immunol 2006 Jun 15;176(12):7394-401 PMID: 16751384 SCOPUS ID: 2-s2.0-33744913796 06/06/2006       40 Citations
  • T-cell tolerance or function is determined by combinatorial costimulatory signals. (Nurieva R, Thomas S, Nguyen T, Martin-Orozco N, Wang Y, Kaja MK, Yu XZ, Dong C) EMBO J 2006 Jun 07;25(11):2623-33 PMID: 16724117 PMCID: PMC1478197 SCOPUS ID: 2-s2.0-33745736420 05/26/2006       185 Citations
  • T regulatory cells as an immunotherapy for transplantation. (Albert MH, Anasetti C, Yu XZ) Expert Opin Biol Ther 2006 Apr;6(4):315-24 PMID: 16548760 SCOPUS ID: 2-s2.0-33645791830 03/22/2006       19 Citations
  • Alloantigen affinity and CD4 help determine severity of graft-versus-host disease mediated by CD8 donor T cells. (Yu XZ, Albert MH, Anasetti C) J Immunol 2006 Mar 15;176(6):3383-90 PMID: 16517706 SCOPUS ID: 2-s2.0-33644848095 03/07/2006       23 Citations
  • Memory stem cells sustain disease. (Yu XZ, Anasetti C) Nat Med 2005 Dec;11(12):1282-3 PMID: 16333266 SCOPUS ID: 2-s2.0-28644433207 12/08/2005       4 Citations
  • Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation. (Albert MH, Liu Y, Anasetti C, Yu XZ) Eur J Immunol 2005 Sep;35(9):2598-607 PMID: 16078276 SCOPUS ID: 2-s2.0-26044458206 08/04/2005       72 Citations
  • Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. (Albert MH, Yu XZ, Martin PJ, Anasetti C) Blood 2005 Feb 01;105(3):1355-61 PMID: 15459004 SCOPUS ID: 2-s2.0-12844288851 10/02/2004       19 Citations
  • CD28 ligation induces transplantation tolerance by IFN-gamma-dependent depletion of T cells that recognize alloantigens. (Yu XZ, Albert MH, Martin PJ, Anasetti C) J Clin Invest 2004 Jun;113(11):1624-30 PMID: 15173889 PMCID: PMC419490 SCOPUS ID: 2-s2.0-85047693292 06/03/2004       55 Citations
  • Lck is required for activation-induced T cell death after TCR ligation with partial agonists. (Yu XZ, Levin SD, Madrenas J, Anasetti C) J Immunol 2004 Feb 01;172(3):1437-43 PMID: 14734719 SCOPUS ID: 2-s2.0-1642526001 01/22/2004       16 Citations
  • CD28 signal enhances apoptosis of CD8 T cells after strong TCR ligation. (Yu XZ, Martin PJ, Anasetti C) J Immunol 2003 Mar 15;170(6):3002-6 PMID: 12626553 SCOPUS ID: 2-s2.0-0037443420 03/11/2003       28 Citations
  • Additive effects of anti-CD3 and anti-CD28 prolongation of allogeneic skin graft survival. (Yu XZ, Nitta Y, Bidwell SJ, Anasetti C) Transplantation 2001 Dec 15;72(11):1862 PMID: 11740406 SCOPUS ID: 2-s2.0-0035892779 12/12/2001       1 Citation
  • Anti-CD3 epsilon F(ab')2 prevents graft-versus-host disease by selectively depleting donor T cells activated by recipient alloantigens. (Yu XZ, Bidwell SJ, Martin PJ, Anasetti C) J Immunol 2001 May 01;166(9):5835-9 PMID: 11313428 SCOPUS ID: 2-s2.0-0035324638 04/21/2001       32 Citations
  • Non-Fc receptor-binding humanized anti-CD3 antibodies induce apoptosis of activated human T cells. (Carpenter PA, Pavlovic S, Tso JY, Press OW, Gooley T, Yu XZ, Anasetti C) J Immunol 2000 Dec 01;165(11):6205-13 PMID: 11086054 SCOPUS ID: 2-s2.0-0034547959 11/22/2000       80 Citations
  • CD28-specific antibody prevents graft-versus-host disease in mice. (Yu XZ, Bidwell SJ, Martin PJ, Anasetti C) J Immunol 2000 May 01;164(9):4564-8 PMID: 10779758 SCOPUS ID: 2-s2.0-0034192104 04/26/2000       78 Citations
  • Enhancement of susceptibility to Fas-mediated apoptosis of TH1 cells by nonmitogenic anti-CD3epsilon F(ab')2. (Yu XZ, Anasetti C) Transplantation 2000 Jan 15;69(1):104-12 PMID: 10653388 SCOPUS ID: 2-s2.0-0034650845 02/01/2000       12 Citations
  • Visualization, fate, and pathogenicity of antigen-specific CD8+ T cells in the graft-versus-host reaction. (Yu XZ, Bidwell S, Martin PJ, Anasetti C) J Immunol 1999 Nov 01;163(9):4780-7 PMID: 10528177 SCOPUS ID: 2-s2.0-0032754034 10/21/1999       14 Citations
  • Role of CD28 in acute graft-versus-host disease. (Yu XZ, Martin PJ, Anasetti C) Blood 1998 Oct 15;92(8):2963-70 PMID: 9763584 SCOPUS ID: 2-s2.0-0032532609 10/09/1998       55 Citations
  • Induction of apoptosis by anti-CD3 epsilon F(ab')2 in antigen receptor transgenic murine T cells activated by specific peptide. (Yu XZ, Zhu L, Davis JE, Tso JY, Hansen JA, Anasetti C) J Immunol 1996 Oct 15;157(8):3420-9 PMID: 8871640 SCOPUS ID: 2-s2.0-0030587902 10/15/1996       18 Citations
  • Cell cycle control of T cell apoptosis induced by activation through the T cell antigen receptor. (Chalupny NJ, Zhu L, Yu XZ, Anasetti C) Adv Exp Med Biol 1996;406:57-67 PMID: 8910671 SCOPUS ID: 2-s2.0-0029908187 01/01/1996    
  • Last update: 02/02/2022