Medical College of Wisconsin
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Ze Zheng PhD

Ze Zheng PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Medicine
Division: Endocrinology
Program: Research

Member of the Cardiovascular Center


I am willing to mentor a junior faculty member.
I am willing to collaborate on research projects.


Research Experience

  • Atherosclerosis
  • Circadian Rhythm
  • Fatty Liver
  • Fibrinolysis
  • Lipoproteins
  • Liver Cirrhosis
  • Metabolic Syndrome
  • Obesity
  • Thrombosis
  • Publications (31)

  • Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity. (Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I) J Clin Invest 2020 Aug 03;130(8):4348-4359 PMID: 32657780 PMCID: PMC7410057 SCOPUS ID: 2-s2.0-85089125237 07/14/2020    
  • Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. (Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, Levin LR, Tontonoz P, Schwabe RF, Tabas I) Cell Metab 2020 May 05;31(5):969-986.e7 PMID: 32259482 PMCID: PMC7313619 SCOPUS ID: 2-s2.0-85083861208 04/08/2020       2 Citations
  • Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. (Yurdagul A Jr, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM, Tabas I) Cell Metab 2020 Mar 03;31(3):518-533.e10 PMID: 32004476 PMCID: PMC7173557 SCOPUS ID: 2-s2.0-85080068507 02/01/2020       7 Citations
  • Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. (Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I) Cell Metab 2020 02 04;31(2):406-421.e7 PMID: 31839486 PMCID: PMC7004886 SCOPUS ID: 2-s2.0-85078479595 12/17/2019       10 Citations
  • An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. (Zheng Z, Nayak L, Wang W, Yurdagul A Jr, Wang X, Cai B, Lapping S, Ozcan L, Ramakrishnan R, Pestell RG, Jain MK, Tabas I) Blood 2019 02 14;133(7):743-753 PMID: 30504459 PMCID: PMC6376283 SCOPUS ID: 2-s2.0-85061475922 12/07/2018       3 Citations
  • Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. (Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Blüher M, Czech MP, Tabas I) Nature 2018 03 29;555(7698):673-677 PMID: 29562231 PMCID: PMC6021131 SCOPUS ID: 2-s2.0-85044788933 03/22/2018       66 Citations
  • Interaction between stress responses and circadian metabolism in metabolic disease. (Yang Z, Kim H, Ali A, Zheng Z, Zhang K) Liver Res 2017 Sep;1(3):156-162 PMID: 29430321 PMCID: PMC5805151 SCOPUS ID: 2-s2.0-85051645629 02/13/2018    
  • Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in Mice Fed High-fat Diet by Stimulating Hepatic Autophagy. (Qiu Y, Zheng Z, Kim H, Yang Z, Zhang G, Shi X, Sun F, Peng C, Ding Y, Wang A, Chen LC, Rajagopalan S, Sun Q, Zhang K) Sci Rep 2017 11 24;7(1):16286 PMID: 29176715 PMCID: PMC5701159 SCOPUS ID: 2-s2.0-85034992166 11/28/2017       12 Citations
  • CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis. (Doran AC, Ozcan L, Cai B, Zheng Z, Fredman G, Rymond CC, Dorweiler B, Sluimer JC, Hsieh J, Kuriakose G, Tall AR, Tabas I) J Clin Invest 2017 Nov 01;127(11):4075-4089 PMID: 28972541 PMCID: PMC5663361 SCOPUS ID: 2-s2.0-85032982234 10/04/2017       21 Citations
  • CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis. (Kim H, Zheng Z, Walker PD, Kapatos G, Zhang K) Mol Cell Biol 2017 07 15;37(14) PMID: 28461393 PMCID: PMC5492176 SCOPUS ID: 2-s2.0-85021826450 05/04/2017       16 Citations
  • Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis. (Wang X, Zheng Z, Caviglia JM, Corey KE, Herfel TM, Cai B, Masia R, Chung RT, Lefkowitch JH, Schwabe RF, Tabas I) Cell Metab 2016 12 13;24(6):848-862 PMID: 28068223 PMCID: PMC5226184 SCOPUS ID: 2-s2.0-85003945921 01/10/2017       75 Citations
  • Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin. (Dandekar A, Qiu Y, Kim H, Wang J, Hou X, Zhang X, Zheng Z, Mendez R, Yu FS, Kumar A, Fang D, Sun F, Zhang K) J Biol Chem 2016 10 28;291(44):23149-23158 PMID: 27637329 PMCID: PMC5087733 SCOPUS ID: 2-s2.0-84993982959 10/30/2016       8 Citations
  • CREBH Couples Circadian Clock With Hepatic Lipid Metabolism. (Zheng Z, Kim H, Qiu Y, Chen X, Mendez R, Dandekar A, Zhang X, Zhang C, Liu AC, Yin L, Lin JD, Walker PD, Kapatos G, Zhang K) Diabetes 2016 Nov;65(11):3369-3383 PMID: 27507854 PMCID: PMC5079639 SCOPUS ID: 2-s2.0-84993975770 08/11/2016       24 Citations
  • Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance. (Ozcan L, Ghorpade DS, Zheng Z, de Souza JC, Chen K, Bessler M, Bagloo M, Schrope B, Pestell R, Tabas I) Cell Rep 2016 06 07;15(10):2214-2225 PMID: 27239042 PMCID: PMC5068925 SCOPUS ID: 2-s2.0-84969980373 05/31/2016       19 Citations
  • Transcriptional signatures of unfolded protein response implicate the limitation of animal models in pathophysiological studies. (Zheng Z, Wang G, Li L, Tseng J, Sun F, Chen X, Chang L, Heng H, Zhang K) Environ Dis 2016;1(1):24-30 PMID: 28265594 PMCID: PMC5336312 01/01/2016    
  • A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression (Zhang X, Cai J, Zheng Z, Polin L, Lin Z, Dandekar A, Li L, Sun F, Finley RL, Fang D, Yang ZQ, Zhang K) Cell Discovery 8 September 2015;1 SCOPUS ID: 2-s2.0-84983772454 09/08/2015    
  • Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models. (Zheng Z, Zhang X, Wang J, Dandekar A, Kim H, Qiu Y, Xu X, Cui Y, Wang A, Chen LC, Rajagopalan S, Sun Q, Zhang K) J Hepatol 2015 Dec;63(6):1397-404 PMID: 26220751 PMCID: PMC5003300 SCOPUS ID: 2-s2.0-84951567255 07/30/2015       57 Citations
  • A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. (Zhang X, Cai J, Zheng Z, Polin L, Lin Z, Dandekar A, Li L, Sun F, Finley RL Jr, Fang D, Yang ZQ, Zhang K) Cell Discov 2015;1:15024 PMID: 27462423 PMCID: PMC4860859 01/01/2015    
  • Liver-enriched transcription factor CREBH interacts with peroxisome proliferator-activated receptor α to regulate metabolic hormone FGF21. (Kim H, Mendez R, Zheng Z, Chang L, Cai J, Zhang R, Zhang K) Endocrinology 2014 Mar;155(3):769-82 PMID: 24424044 PMCID: PMC3929740 SCOPUS ID: 2-s2.0-84896838463 01/16/2014       66 Citations
  • Diabetes mellitus is associated with hepatocellular carcinoma: a retrospective case-control study in hepatitis endemic area. (Zheng Z, Zhang C, Yan J, Ruan Y, Zhao X, San X, Mao Y, Sun Q, Zhang K, Fan Z) PLoS One 2013;8(12):e84776 PMID: 24386416 PMCID: PMC3873428 SCOPUS ID: 2-s2.0-84891299084 01/05/2014       16 Citations
  • Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. (Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, Kaufman RJ, Yang WL, Lin HK, Zhang D, Perlman H, Thorp E, Zhang K, Fang D) EMBO J 2013 Sep 11;32(18):2477-90 PMID: 23942232 PMCID: PMC3770952 SCOPUS ID: 2-s2.0-84884292103 08/15/2013       92 Citations
  • Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue. (Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K) Am J Transl Res 2013;5(2):224-34 PMID: 23573366 PMCID: PMC3612517 04/11/2013    
  • Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue (Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K) American Journal of Translational Research 2013;5(2):224-234 SCOPUS ID: 2-s2.0-84875762872 01/01/2013    
  • Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. (Zheng Z, Xu X, Zhang X, Wang A, Zhang C, Hüttemann M, Grossman LI, Chen LC, Rajagopalan S, Sun Q, Zhang K) J Hepatol 2013 Jan;58(1):148-54 PMID: 22902548 PMCID: PMC3527686 SCOPUS ID: 2-s2.0-84871231019 08/21/2012       117 Citations
  • ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. (Wang G, Liu G, Wang X, Sethi S, Ali-Fehmi R, Abrams J, Zheng Z, Zhang K, Ethier S, Yang ZQ) BMC Cancer 2012 Jun 08;12:225 PMID: 22681620 PMCID: PMC3732090 SCOPUS ID: 2-s2.0-84861940241 06/12/2012       20 Citations
  • Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. (Lee JS, Zheng Z, Mendez R, Ha SW, Xie Y, Zhang K) Toxicol Lett 2012 May 20;211(1):29-38 PMID: 22414386 PMCID: PMC3334434 SCOPUS ID: 2-s2.0-84858987289 03/15/2012       86 Citations
  • Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. (Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K) Hepatology 2012 Apr;55(4):1070-82 PMID: 22095841 PMCID: PMC3319338 SCOPUS ID: 2-s2.0-84862828272 11/19/2011       121 Citations
  • Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. (Zheng Z, Zhang C, Zhang K) Methods Enzymol 2011;489:329-48 PMID: 21266239 SCOPUS ID: 2-s2.0-79251525864 01/27/2011       21 Citations
  • Role of unfolded protein response in lipogenesis. (Zheng Z, Zhang C, Zhang K) World J Hepatol 2010 Jun 27;2(6):203-7 PMID: 21160998 PMCID: PMC2999286 12/17/2010    
  • Role of unfolded protein response in lipogenesis (Zheng Z, Zhang C, Zhang K) World Journal of Hepatology 2010;2(6):203-207 SCOPUS ID: 2-s2.0-80052828973 12/01/2010    
  • Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. (Laing S, Wang G, Briazova T, Zhang C, Wang A, Zheng Z, Gow A, Chen AF, Rajagopalan S, Chen LC, Sun Q, Zhang K) Am J Physiol Cell Physiol 2010 Oct;299(4):C736-49 PMID: 20554909 PMCID: PMC2957267 SCOPUS ID: 2-s2.0-77957673495 06/18/2010       110 Citations
  • Last update: 09/09/2020
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