Faculty Collaboration Database

Sarcoma arising in hyaline-vascular castleman disease of skin and subcutis. Am J Dermatopathol 2005 Aug;27(4):327-32

Date

08/27/2005

Pubmed ID

16121055

DOI

10.1097/01.dad.0000171606.55810.86

Scopus ID

2-s2.0-24144472520 (requires institutional sign-in at Scopus site)   25 Citations

Abstract

We report on a case of a sarcoma arising in the hyaline-vascular variant of Castleman disease (HVCD) of the skin and subcutis. The patient was a 38-year-old man who clinically presented with a subcutaneous non-fixed cyst-like mass on his right shoulder with an unremarkable prior medical history. Histologic sections showed a biphasic tumor with numerous atretic lymphoid follicles located in the deep dermis and subcutis and a spindle-cell neoplasm mainly situated in the deep subcutis and adjacent soft tissue. The atretic lymphoid component fulfilled the criteria for HVCD, whereas the spindle-cell lesion showed all the criteria for sarcoma including nuclear atypia and frequent mitotic figures. The sarcomatous component was diffusely positive for fascin, nerve growth factor receptor, and CD34 with focal weak reactivity for CD21 and CNA.42. Stains for CD23, CD31, CD35, CD99, ALK-1, SMA, ASMA, desmin, factor XIIIa, AE1-AE3, EMA, bcl-2, S-100, Melan-A, HMB-45, Cam 5.2, and factor VIII were negative in the neoplastic spindle cells. No monoclonal population of lymphocytes was detected and we could not identify EBV or HHV-8 virus by PCR. Electron microscopy of the sarcomatous component showed spindle cells with labyrinth-like invaginations of the nucleus and numerous long, slender, interwoven cytoplasmic processes. The sarcomatous component in this case is most consistent with a poorly differentiated follicular dendritic cell sarcoma based upon the morphologic and ultrastructural findings.

Author List

Kazakov DV, Morrisson C, Plaza JA, Michal M, Suster S

MESH terms used to index this publication - Major topics in bold

Adult
Biomarkers, Tumor
Castleman Disease
Humans
Immunohistochemistry
Male
Microscopy, Electron, Transmission
Polymerase Chain Reaction
Sarcoma
Skin Neoplasms
Subcutaneous Tissue