Faculty Collaboration Database

Erythromycin lacks colon prokinetic effect in children with functional gastrointestinal disorders: a retrospective study. BMC Gastroenterol 2008 Aug 21;8:38

Date

08/23/2008

Pubmed ID

18718006

Pubmed Central ID

PMC2529327

DOI

10.1186/1471-230X-8-38

Scopus ID

2-s2.0-51349121877 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

BACKGROUND: Motilin, a peptide hormone has a direct excitatory effect on circular smooth muscle strips derived from the human colon. Reduced plasma motilin concentration has been reported in adults with chronic constipation. Erythromycin, a non-peptide motilin receptor agonist, induces phase 3 of the migrating motor complex (MMC) in the antro-duodenum and also reduces oro-cecal transit time. A pediatric study has reported an improvement in clinical symptoms of constipation following erythromycin administration, but the effect on colon motility in children has not been formally evaluated. We used colon manometry to study the effect of intravenous erythromycin lactobionate at 1 mg/kg on colon motility in ten children.

METHODS: We selected patients with normal antroduodenal and colon manometry studies that were performed simultaneously. All studies were performed for clinically indicated reasons. We quantified the effect of erythromycin on colon contraction by calculating the area under the curve (AUC).

RESULTS: The mean (SE of mean) AUC in the colon during the fasting, post-erythromycin and postprandial phases of the study was 2.1 mmHg/sec (0.35), 0.99 mmHg/sec (0.17) and 3.05 mmHg/sec (0.70) respectively. The AUC following erythromycin was significantly less compared to the fasting phase of the study (p < 0.01).

CONCLUSION: Erythromycin lacks colon prokinetic effect in children with chronic constipation evaluated by colon manometry.

Author List

Venkatasubramani N, Rudolph CD, Sood MR

MESH terms used to index this publication - Major topics in bold

Child
Child, Preschool
Colon
Constipation
Dose-Response Relationship, Drug
Erythromycin
Fecal Incontinence
Female
Gastrointestinal Agents
Gastrointestinal Diseases
Gastrointestinal Motility
Humans
Male
Manometry
Muscle Contraction
Muscle, Smooth
Peristalsis
Receptors, Gastrointestinal Hormone
Receptors, Neuropeptide
Retrospective Studies
Treatment Outcome