Neonatal alloimmune thrombocytopenia after maternal immunization with paternal mononuclear cells: successful treatment with intravenous gamma globulin. Am J Perinatol 1992;9(5-6):448-51
Date
09/01/1992Pubmed ID
1418154DOI
10.1055/s-2007-999286Scopus ID
2-s2.0-0026497824 (requires institutional sign-in at Scopus site) 25 CitationsAbstract
We report a case of neonatal alloimmune thrombocytopenia and intracranial hemorrhage in an infant whose mother received immunizations of paternal mononuclear cells. This therapy is designed to prevent unexplained first trimester miscarriages. No previous cases of platelet autoimmunization associated with maternal immunization with paternal mononuclear cells has been reported. Treatment with antenatal maternal infusions of intravenous gamma globulin (IVGG) did not prevent fetal thrombocytopenia, but IVGG may become the treatment of choice for postnatal, antibody-mediated thrombocytopenia of the newborn.
Author List
Pearlman SA, Meek RS, Cowchock FS, Smith JB, McFarland J, Aster RHMESH terms used to index this publication - Major topics in bold
Abortion, HabitualAdult
Cerebral Hemorrhage
Female
Humans
Immunization
Immunoglobulin G
Immunoglobulins, Intravenous
Infant, Newborn
Maternal-Fetal Exchange
Monocytes
Pregnancy
Prenatal Exposure Delayed Effects
Thrombocytopenia
