Faculty Collaboration Database

Inflammatory Cytokine Networks in Gastrointestinal Tract Graft vs. Host Disease. Front Immunol 2019;10:163

Date

03/12/2019

Pubmed ID

30853956

Pubmed Central ID

PMC6395399

DOI

10.3389/fimmu.2019.00163

Scopus ID

2-s2.0-85062722237 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

Graft vs. host disease (GVHD) is the major non-relapse complication associated with allogeneic hematopoietic stem cell transplantation (HSCT). Damage to the gastrointestinal (GI) tract from acute GVHD is a particularly serious event that can result in significant morbidity and mortality. Proinflammatory cytokines play a critical role in the pathophysiology of intestinal GVHD, in part by activating donor T cell populations which subsequently induce tissue damage. In this review, we summarize pre-clinical data derived from experimental murine models that have examined the role of inflammatory cytokine pathways that play critical roles in the pathophysiology of GVHD of the GI tract. Specific areas of focus are on STAT 3-dependent cytokines (e.g., IL-6, IL-23, and IL-21), and members of the IL-1 cytokine family, both of which have been shown to induce pathological damage within the GI tract during this disease. We also review established and ongoing efforts to translate these pre-clinical findings into the clinic in an effort to reduce morbidity and mortality due to this complication.

Author List

Piper C, Drobyski WR

Author

William R. Drobyski MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Cytokines
Disease Models, Animal
Gastrointestinal Diseases
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Inflammation Mediators
Lymphocyte Activation
STAT3 Transcription Factor
T-Lymphocytes
Transplantation, Homologous