Population-based study of islet cell carcinoma. Ann Surg Oncol 2007 Dec;14(12):3492-500
Date
09/27/2007Pubmed ID
17896148Pubmed Central ID
PMC2077912DOI
10.1245/s10434-007-9566-6Scopus ID
2-s2.0-36348967668 (requires institutional sign-in at Scopus site) 293 CitationsAbstract
BACKGROUND: We examine the epidemiology, natural history, and prognostic factors that affect the duration of survival for islet cell carcinoma by using population-based registries.
METHODS: The Surveillance, Epidemiology, and End Results (SEER) Program database (1973-2003 release, April 2006) was used to identify cases of islet cell carcinoma by histology codes and tumor site.
RESULTS: A total of 1310 (619 women and 691 men) cases with a median age of 59 years were identified. The annual age-adjusted incidence in the periods covered by SEER 9 (1973-1991), SEER 13 (1992-1999), and SEER 17 (2000-2003) were .16, .14, and .12 per 100,000, respectively. The estimated 28-year limited duration prevalence on January 1, 2003, in the United States was 2705 cases. Classified by SEER stage, localized, regional, and distant stages corresponded to 14%, 23%, and 54% of cases. The median survival was 38 months. By stage, median survival for patients with localized, regional, and distant disease were 124 (95% CI, 80-168) months, 70 (95% CI, 54-86) months, and 23 (95% CI, 20-26) months, respectively. By multivariate Cox proportional modeling, stage (P < .001), primary tumor location (P = .04), and age at diagnosis (P < .001) were found to be significant predictors of survival.
CONCLUSIONS: Islet cell carcinomas account for approximately 1.3% of cancers arising in the pancreas. Most patients have advanced disease at the time of diagnosis. Despite the disease's reputation of being indolent, survival of patients with advanced disease remains only 2 years. Development of novel therapeutic approaches is needed.
Author List
Yao JC, Eisner MP, Leary C, Dagohoy C, Phan A, Rashid A, Hassan M, Evans DBAuthor
Douglas B. Evans MD Chair, Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Age Distribution
Aged
Aged, 80 and over
Carcinoma, Islet Cell
Child
Child, Preschool
Female
Gastrinoma
Glucagonoma
Humans
Incidence
Infant
Infant, Newborn
Insulinoma
Male
Middle Aged
Neoplasm Staging
Pancreatic Neoplasms
Prognosis
Registries
SEER Program
Survival Rate
United States
Vipoma
