EPI imaging of global increase of brain MR signal with breath-hold preceded by breathing O2. Magn Reson Med 1995 Mar;33(3):448-52
Date
03/01/1995Pubmed ID
7760716DOI
10.1002/mrm.1910330322Scopus ID
2-s2.0-0028922844 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
Brain MR signal has been observed to decrease during cessation of breathing due to the increase of deoxyhemoglobin in the blood. However, for both animal and human studies, we have demonstrated that if the subjects breathed 100% oxygen in advance of apnea for a short time, T2*-weighted MR brain signal increased when breathing was stopped for a period of 30-60 s. This demonstrates the possibility of measuring responses to hemodynamic change throughout the entire brain with a single respiratory perturbation in a rapid, reliable, and robust manner.
Author List
Kwong KK, Wanke I, Donahue KM, Davis TL, Rosen BRAuthor
Kathleen M. Schmainda PhD Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsApnea
Brain
Carbon Dioxide
Echo-Planar Imaging
Hemoglobins
Humans
Hypercapnia
Image Enhancement
Magnetic Resonance Imaging
Oximetry
Oxygen
Oxygen Consumption
Rabbits
Respiration
