Methods of Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III). Semin Nucl Med 2008 Nov;38(6):462-70
Date
04/01/2009Pubmed ID
19331840Pubmed Central ID
PMC2605689DOI
10.1053/j.semnuclmed.2008.06.003Scopus ID
2-s2.0-53149100139 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
In this work, the methods of the Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III) are described in detail. PIOPED III is a multicenter collaborative investigation sponsored by the National Heart, Lung and Blood Institute. The purpose is to determine the accuracy of gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography for the diagnosis of acute pulmonary embolism (PE). A composite reference standard based on usual diagnostic methods for PE is used. All images will be read by 2 blinded and study-certified central readers. Patients with no PE according to the composite reference test will be randomized to undergo gadolinium-enhanced magnetic resonance angiography in combination with venous phase magnetic resonance venography. This procedure will reduce the proportion of patients with negative tests at no loss in evaluation of sensitivity and specificity.
Author List
Stein PD, Gottschalk A, Sostman HD, Chenevert TL, Fowler SE, Goodman LR, Hales CA, Hull RD, Kanal E, Leeper KV Jr, Nadich DP, Sak DJ, Tapson VF, Wakefield TW, Weg JG, Woodard PKMESH terms used to index this publication - Major topics in bold
Acute DiseaseClinical Protocols
Contrast Media
Fibrin Fibrinogen Degradation Products
Gadolinium
Humans
Magnetic Resonance Angiography
National Heart, Lung, and Blood Institute (U.S.)
Phlebography
Prospective Studies
Pulmonary Artery
Pulmonary Embolism
Sensitivity and Specificity
Tomography, Spiral Computed
Ultrasonography
United States
Venous Thrombosis
