Faculty Collaboration Database

Optic chiasm glioma associated with inappropriate secretion of antidiuretic hormone, cerebral ischemia, nonobstructive hydrocephalus and chronic ascites following ventriculoperitoneal shunting. Childs Nerv Syst 1991 Dec;7(8):458-61

Date

12/01/1991

Pubmed ID

1790531

DOI

10.1007/BF00263189

Scopus ID

2-s2.0-0026317599 (requires institutional sign-in at Scopus site)   26 Citations

Abstract

An optic chiasm glioma may cause loss of vision, endocrine disturbances, hydrocephalus and cerebral ischemia due to its proximity to the pituitary, hypothalamus, III ventricle and internal carotids. A 3-month-old infant with optic chiasm glioma developed hypopituitarism and inappropriate secretion of antidiuretic hormone with plasma hypo-osmolality. The cerebrospinal fluid (CSF) protein concentration was markedly elevated. The impairment of fluid absorption via arachnoid villi and peritoneum by the high protein content, and reversed osmotic gradient between protein-rich CSF and hypo-osmolar plasma may have contributed to both nonobstructive hydrocephalus and recurrent ascites following ventriculoperitoneal shunting. Cerebral ischemia from carotid compression may have led to cerebral atrophy.

Author List

Tang TT, Whelan HT, Meyer GA, Strother DR, Blank EL, Camitta BM, Franciosi RA

Authors

Bruce m. Camitta Professor in the Pediatrics department at Medical College of Wisconsin
Harry Whelan MD Emeritus Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Ascites
Astrocytoma
Biopsy
Cerebrospinal Fluid Shunts
Cranial Nerve Neoplasms
Female
Humans
Hydrocephalus
Inappropriate ADH Syndrome
Infant
Optic Chiasm
Postoperative Complications
Reoperation