Hyperautofluorescent ring in autoimmune retinopathy. Retina 2012 Jul;32(7):1385-94
Date
01/06/2012Pubmed ID
22218149Pubmed Central ID
PMC4377132DOI
10.1097/IAE.0b013e3182398107Scopus ID
2-s2.0-84862868352 (requires institutional sign-in at Scopus site) 62 CitationsAbstract
PURPOSE: To report the presence of a hyperautofluorescent ring and corresponding spectral-domain optical coherence tomography (SD-OCT) features seen in patients with autoimmune retinopathy.
METHODS: All eyes were evaluated by funduscopic examination, full-field electroretinography, fundus autofluorescence, and SD-OCT. Further confirmation of the diagnosis was obtained with immunoblot and immunohistochemistry testing of the patient's serum. Humphrey visual fields and microperimetry were also performed.
RESULTS: Funduscopic examination showed atrophic retinal pigment epithelium (RPE) associated with retinal artery narrowing but without pigment deposits. The scotopic and photopic full-field electroretinograms were nondetectable in three patients and showed a cone-rod pattern of dysfunction in one patient. Fundus autofluorescence revealed a hyperautofluorescent ring in the parafoveal region, and the corresponding SD-OCT demonstrated loss of the photoreceptor inner segment-outer segment junction with thinning of the outer nuclear layer from the region of the hyperautofluorescent ring toward the retinal periphery. The retinal layers were generally intact within the hyperautofluorescent ring, although the inner segment-outer segment junction was disrupted, and the outer nuclear layer and photoreceptor outer segment layer were thinned.
CONCLUSION: This case series revealed the structure of the hyperautofluorescent ring in autoimmune retinopathy using SD-OCT. Fundus autofluorescence and SD-OCT may aid in the diagnosis of autoimmune retinopathy and may serve as a tool to monitor its progression.
Author List
Lima LH, Greenberg JP, Greenstein VC, Smith RT, Sallum JM, Thirkill C, Yannuzzi LA, Tsang SHMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Atrophy
Autoantibodies
Autoantigens
Autoimmune Diseases
Female
Fluorescein Angiography
Humans
Male
Middle Aged
Paraneoplastic Syndromes, Ocular
Photoreceptor Cells, Vertebrate
Retina
Retinal Artery
Retinal Diseases
Retinal Pigment Epithelium
Scotoma
Tomography, Optical Coherence
Visual Field Tests
Visual Fields
