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Effects of NaCl on renin and aldosterone responses to potassium depletion. Am J Physiol 1983 Feb;244(2):E164-9

Date

02/11/1983

Pubmed ID

6337502

DOI

10.1152/ajpendo.1983.244.2.E164

Scopus ID

2-s2.0-0020712997 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

We have previously suggested that renin secretion is inversely related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Potassium depletion inhibits chloride transport at this site in the nephron. Consequently, we studied the effects of varying sodium and chloride intakes on the renin and aldosterone responses to potassium depletion. Potassium depletion prevented suppression of plasma renin activity (PRA) by dietary NaCl loading and augmented the PRA response to NaCl deprivation. PRA was stimulated (P less than 0.01) by selective chloride (without sodium) deprivation, and potassium depletion did not augment this response. Potassium depletion did not interfere with suppression of PRA by albumin-induced volume expansion. Plasma aldosterone was suppressed by potassium depletion, and the effect of potassium depletion on aldosterone was augmented by NaCl deprivation. In conclusion, the magnitude of PRA stimulation and aldosterone suppression by potassium depletion is modulated by dietary NaCl intake. The results are consistent with the hypothesis that potassium depletion stimulates renin release by inhibiting chloride transport in the loop of Henle.

Author List

Kotchen TA, Guthrie GP Jr, Galla JH, Luke RG, Welch WJ

MESH terms used to index this publication - Major topics in bold

Aldosterone
Animals
Chlorides
Desoxycorticosterone
Hematocrit
Male
Potassium
Rats
Rats, Inbred Strains
Renin
Sodium
Sodium Chloride