Faculty Collaboration Database

Effect of age on red cell membrane sodium -potassium dependent adenosine triphosphatase (Na+-K+ ATPase) activity in healthy men. J Gerontol 1983 Jan;38(1):23-5

Date

01/01/1983

Pubmed ID

6294172

DOI

10.1093/geronj/38.1.23

Scopus ID

2-s2.0-0020681466 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

Decreased cellular thermogenesis may represent a normal aspect of the aging process. Whereas Na+-K+ ATPase appears to be involved directly in body metabolism, enzyme activity on the erythrocyte membrane Na+-K+ ATPase was significantly lower in aged men. In a separate series of experiments, each with representation from the two age groups, red cell membrane Na+-K+ ATPase was also found to be decreased significantly in the aged men. Although mean values were statistically different, one of the elderly men had enzyme activity above that of the mean of the younger men. None of the younger men had enzyme activity below the mean of the older group. Red cell membrane Na+-,+ ATPase activity may be an indicator of physiological aging.

Author List

Gambert SR, Duthie EH Jr

Author

Edmund H. Duthie MD Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aging
Erythrocyte Membrane
Erythrocytes
Humans
Male
Middle Aged
Sodium-Potassium-Exchanging ATPase