Gender disparities in liver transplant candidates with nonalcoholic steatohepatitis. Clin Transplant 2018 Aug;32(8):e13297
Date
05/29/2018Pubmed ID
29804305DOI
10.1111/ctr.13297Scopus ID
2-s2.0-85050650950 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is the fastest growing indication for liver transplantation (LT). Data from the UNOS database were used to compare rates of listing and LT between men and women with NASH.
METHODS: The study population consisted of 76 149 patients listed for LT between 2005 and 2012, 5 492 (7.2%) of who were listed for NASH. Patient characteristics and outcomes were compared by gender.
RESULTS: Nonalcoholic steatohepatitis was a more frequent indication for transplant listing in women than men throughout the study period. Women had lower serum creatinine levels at listing (1.18 ± 0.76 mg/dL vs 1.28 ± 0.79 mg/dL, P < .001) and were less likely to be listed with exception points (17.7% vs 24.9%, P < .001). Transplantation was less common among women than men with NASH (52.4% vs 64.3%), and women were more likely to experience death on the waiting list (17.1% vs 11.4%) In multivariable analysis adjusting for covariates, the rate of LT remained lower for women with NASH (aHR 0.81 95% CI: 0.75-0.88).
CONCLUSIONS: Women with NASH cirrhosis had a higher risk of death on the LT waiting list and were less likely to receive LT compared to men.
Author List
Loy VM, Joyce C, Bello S, VonRoenn N, Cotler SJMESH terms used to index this publication - Major topics in bold
FemaleFollow-Up Studies
Humans
Liver Transplantation
Male
Middle Aged
Non-alcoholic Fatty Liver Disease
Prognosis
Retrospective Studies
Risk Factors
Sex Factors
Survival Rate
Tissue and Organ Procurement
Waiting Lists
