Halothane diminishes changes in cardiac fiber action potential duration induced by hypocarbia and hypercarbia. Anesthesiology 1984 Sep;61(3):245-53
Date
09/01/1984Pubmed ID
6433748DOI
10.1097/00000542-198409000-00003Scopus ID
2-s2.0-0021277609 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
Both halothane (HAL) and acid-base changes produce cardiac arrhythmias in humans. The authors' aim was to determine if HAL alters the effects of hypercapnic acidosis and hypocapnic alkalosis on action potential (AP) properties of ventricular muscle fibers. They superfused the paced right ventricle of 15 guinea pig hearts with non-HCO3- buffered salt solution and recorded transmembrane APs with 3 M KCl microelectrodes in 35 subendocardial cells. Random changes in the fractions of HAL were made during low (12% CO2 in O2), normal (5% CO2 in O2), and high (0% CO2 in O2) pH. Compared with controls at pH 7.44, AP duration (APD) and effective refractory period (ERP) significantly decreased by 7 and 4% at pH 8.08 and increased by 7 and 9% at pH 7.09. At pH 7.44, 0.7-2.1% HAL produced no change in APD; but 2.1% increased ERP, while 3.5% HAL decreased ERP. At pH 8.08, the decrease in ERP induced with alkalosis alone was converted to an increase with 1.4 and 2.1% HAL. At pH 7.09, 0.7-1.4% HAL had no additional effect on the acidosis-induced increases in APD and ERP, but 2.1 and 2.8% HAL greatly reduced these responses. At HAL fractions greater than 1.4% the marked inverse changes in APD and ERP, induced alone by acidosis and alkalosis, were no longer significantly different from control. This study shows that the opposing effects of alkalosis to shorten and of acidosis to lengthen APD and ERP were attenuated at low levels and abolished at high levels of HAL.(ABSTRACT TRUNCATED AT 250 WORDS)
Author List
Stowe DF, Bosnjak ZJ, Kampine JPMESH terms used to index this publication - Major topics in bold
AcidosisAction Potentials
Alkalosis
Animals
Carbon Dioxide
Depression, Chemical
Guinea Pigs
Halothane
Hydrogen-Ion Concentration
In Vitro Techniques
Membrane Potentials
Myocardial Contraction
