Faculty Collaboration Database

[Differences by age in clinical features of inflammatory bowel disease]. Rev Med Chil 2015 Jun;143(6):689-96

Date

08/01/2015

Pubmed ID

26230551

DOI

10.4067/S0034-98872015000600001

Scopus ID

2-s2.0-84938545791 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

BACKGROUND: Approximately, 15% of patients with Inflammatory Bowel Disease (IBD) are diagnosed at 60 years of age or more.

AIM: To characterize and compare clinical variables between patients with IBD aged 60 years or more and their younger counterparts.

MATERIAL AND METHODS: Retrospective study based on a registry of IBD patients diagnosed between the years 1976 and 2014.

RESULTS: Four hundred and nine IBD patients were included. Among them, 294 had Ulcerative Colitis (UC), 104 had Crohn's Disease (CD) and eleven had an indeterminate IBD. Forty-six patients (11.2%) were older than 60 years and 16 (3.9%) had been diagnosed after this age. When comparing patients by age, those aged 60 years or more had a higher frequency of CD and indeterminate IBD (p < 0.01) and a lower ileocolic location in CD (p = 0.02). Both groups were similar in terms of hospitalization due to IBD flare, surgery, use of steroids, immunosuppressive or biological therapies and drug-related adverse events. When analyzing age at diagnosis of IBD, patients diagnosed at ages of 60 years or more had a lower frequency of UC (p < 0.01), a higher frequency of exclusive colonic involvement (p = 0.01), and lower use of mesalamine (p < 0.01). There were no differences in drug-related adverse events, hospitalizations due to IBD flares and surgery according to age at diagnosis.

CONCLUSIONS: In this population, clinical features of IBD in older patients were similar to those in younger patients.

Author List

Simian D, Estay C, Kronberg U, Yarur A, Castro M, Lubascher J, Acuña R, Quera R

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Age Factors
Aged
Cohort Studies
Colitis, Ulcerative
Crohn Disease
Diagnosis, Differential
Female
Humans
Immunosuppressive Agents
Inflammatory Bowel Diseases
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Young Adult