Late-onset sporadic progressive subcortical gliosis. J Neurol Sci 1998 May 07;157(2):143-7
Date
06/10/1998Pubmed ID
9619636DOI
10.1016/s0022-510x(98)00063-xScopus ID
2-s2.0-0032493135 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
We report two sporadic cases of progressive subcortical gliosis (PSG) with onset after age 60. The presentation included slowly progressive dementia with memory loss, geographic disorientation, and personality change. Both were diagnosed clinically as Alzheimer's disease (AD) and both met NINCDS-ADRDA criteria for probable AD. Autopsy revealed generalized atrophy, predominantly involving the white matter of the frontal and temporal lobes. Microscopically, prominent fibrillary astrocytosis was present in the subcortical white matter and in the subpial and deep layers of the overlying cerebral cortex. Mild cortical neuron loss accompanied the gliosis, but no myelin loss was evident. Amyloid deposits and neuronal cytoskeletal inclusions were absent.
Author List
Lanska DJ, Markesbery WR, Cochran E, Bennett D, Lanska MJ, Cohen MAuthor
Elizabeth J. Cochran MD Adjunct Professor in the Pathology and Laboratory Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAged, 80 and over
Alzheimer Disease
Cerebral Cortex
Diagnosis, Differential
Frontal Lobe
Gliosis
Humans
Male
Substantia Nigra
Temporal Lobe
