Methods for equivalence and noninferiority testing. Biol Blood Marrow Transplant 2009 Jan;15(1 Suppl):120-7
Date
01/29/2009Pubmed ID
19147090Pubmed Central ID
PMC2701110DOI
10.1016/j.bbmt.2008.10.004Scopus ID
2-s2.0-64749104971 (requires institutional sign-in at Scopus site) 105 CitationsAbstract
Classical hypothesis testing focuses on testing whether treatments have differential effects on outcome. However, sometimes clinicians may be more interested in determining whether treatments are equivalent or whether one has noninferior outcomes. We review the hypotheses for these noninferiority and equivalence research questions, consider power and sample size issues, and discuss how to perform such a test for both binary and survival outcomes. The methods are illustrated on 2 recent studies in hematopoietic cell transplantation.
Author List
Tunes da Silva G, Logan BR, Klein JPAuthor
Brent R. Logan PhD Director, Professor in the Data Science Institute department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Hematopoietic Stem Cell TransplantationHumans
Methods
Odds Ratio
Probability
Research Design
Therapeutic Equivalency
Treatment Outcome
