Faculty Collaboration Database

SA11 rotavirus is specifically inhibited by an acetylated sialic acid. J Infect Dis 1990 Jan;161(1):116-9

Date

01/01/1990

Pubmed ID

2153181

DOI

10.1093/infdis/161.1.116

Scopus ID

2-s2.0-0025162148 (requires institutional sign-in at Scopus site)   40 Citations

Abstract

Bovine salivary mucin (BSM) inhibits rotavirus replication in vitro and in vivo. The inhibitory effect of BSM in vitro is abolished by Arthrobacter ureafaciens neuraminidase but not by Clostridia perfringens neuraminidase; it is abolished by mild base deacetylation but not by influenza C acetylesterase. The data suggest that SA11 rotavirus binds to a specific sialic acid structure on BSM different from the sialic acids recognized by other viruses.

Author List

Willoughby RE, Yolken RH

Author

Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acetylation
Animals
Cattle
Chromatography, High Pressure Liquid
Clostridium perfringens
Mucins
N-Acetylneuraminic Acid
Neuraminidase
Neutralization Tests
Receptors, Virus
Rotavirus
Sialic Acids
Virus Replication