Maternal fever and neural tube defects. Teratology 1980 Feb;21(1):105-8
Date
02/01/1980Pubmed ID
6446171DOI
10.1002/tera.1420210114Scopus ID
2-s2.0-0018981512 (requires institutional sign-in at Scopus site) 112 CitationsAbstract
It has been proposed that hyperthermia in the pregnant woman is associated with neural tube defects in her offspring. We analyzed retrospective interview data for a maternal history of probable febrile illness during the first trimester of pregnancy among mothers of infants with anencephaly or spina bifida. There were two control groups--mothers of infants with Down syndrome and mothers of infants with cleft lip or palate. With the Down syndrome group serving as controls, the incidence of febrile illness among mothers of all infants with neural tube defects was significantly elevated. With the cleft group as controls, the fever incidence was not significantly increased in the neural tube defect groups. When the combined cleft and Down syndrome controls were used, only mothers of the spina bifida group had an elevated fever incidence. Epidemiology data suggest an association of maternal fever during pregnancy with neural tube defects in the offspring.
Author List
Layde PM, Edmonds LD, Erickson JDMESH terms used to index this publication - Major topics in bold
AnencephalyCleft Lip
Cleft Palate
Down Syndrome
Female
Fever
Humans
Neural Tube Defects
Pregnancy
Pregnancy Complications
Pregnancy Trimester, First
Retrospective Studies
Spina Bifida Occulta
