Renin and aldosterone responses to short-term NaCl or NaHCO3 loading in man. J Lab Clin Med 1982 Aug;100(2):261-8
Date
08/01/1982Pubmed ID
6284847Scopus ID
2-s2.0-0019965742 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
We compared the effects of 500 ml of 0.15M NaCl or 750 ml of 0.15M NaHCO2, infusions on PRA and PAC in 16 normal NaCl-restricted men. More positive sodium balance, greater natriuresis, and lower serum chloride, potassium, and hydrogen ion concentrations were observed after NaHCO3 infusion. PRA decreased (13.8 +/- 1.0 ng/ml angiotensin I per hour to 6.6 +/- 0.70) and PAC did not change (98 +/- 15 ng/dl to 86 +/- 15) after NaCl infusion. Conversely, PRA did not change (9.9 +/- 1.6 to 10.1 +/- 1.6) and PAC decreased (85 +/- 9 to 44 +/- 5) after NaHCO3 infusion. Plasma cortisol declined in both groups. These results suggest that in sodium-restricted man chloride is more important than sodium for the suppression of PRA by NaCl loading and that potassium or hydrogen ion is a more sensitive modulator of aldosterone secretion than is renin.
Author List
Julian BA, Galla JH, Guthrie GP Jr, Kotchen TAMESH terms used to index this publication - Major topics in bold
AdultAldosterone
Bicarbonates
Chlorides
Diuresis
Electrolytes
Humans
Hydrocortisone
Male
Renin
Renin-Angiotensin System
Sodium Bicarbonate
Sodium Chloride
