Medical College of Wisconsin
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Effects of neuraminidase on the regulation of erythropoiesis. Blood 1984 Apr;63(4):784-8

Date

04/01/1984

Pubmed ID

6608380

DOI

10.1182/blood.v63.4.784.784

Scopus ID

2-s2.0-0021351193 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

In this article, we present evidence that sialic acid-containing surface components play a role in the regulation of erythropoiesis. A 1-hr exposure of mouse bone marrow cells to high concentrations of neuraminidase reduced erythroid colony formation. Coculture of 10(6) untreated thymocytes with neuraminidase-treated bone marrow cells restored erythroid colony growth. Neuraminidase-treated thymocytes retained their ability to suppress erythroid colony formation by untreated marrow cells, but lost their ability to enhance erythroid colony formation. Continuous exposure to low concentrations of neuraminidase enhanced erythroid bone marrow cell colony growth in response to a suboptimal dose of erythropoietin.

Author List

LaRussa VF, Sieber F, Sensenbrenner LL, Sharkis SJ

Author

Fritz Sieber PhD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Bone Marrow Cells
Cell Communication
Colony-Forming Units Assay
Erythropoiesis
Female
Hematopoietic Stem Cells
Mice
Mice, Inbred Strains
Neuraminidase
T-Lymphocytes