Faculty Collaboration Database

The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med 2011 Jun 12;17(7):812-5

Date

06/15/2011

Pubmed ID

21666694

Pubmed Central ID

PMC3374483

DOI

10.1038/nm.2347

Scopus ID

2-s2.0-79960110157 (requires institutional sign-in at Scopus site)   177 Citations

Abstract

Here we report that the transcription factor cyclic AMP-responsive element-binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H-deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance catalyzed by lipoprotein lipase (Lpl), partly due to defective expression of the Lpl coactivators Apoc2, Apoa4 and Apoa5 (encoding apolipoproteins C2, A4 and A5, respectively) and concurrent augmentation of the Lpl inhibitor Apoc3. We identified multiple nonsynonymous mutations in CREB3L3 that produced hypomorphic or nonfunctional CREB-H protein in humans with extreme hypertriglyceridemia, implying a crucial role for CREB-H in human triglyceride metabolism.

Author List

Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH

MESH terms used to index this publication - Major topics in bold

Animals
Apolipoprotein A-V
Apolipoprotein C-II
Apolipoproteins
Apolipoproteins A
Cholesterol, LDL
Cyclic AMP Response Element-Binding Protein
Humans
Hypertriglyceridemia
Lipoprotein Lipase
Mice
Mice, Transgenic
Triglycerides