Faculty Collaboration Database

The effect of hysterectomy on the risk of an abnormal screening Papanicolaou test result. Am J Obstet Gynecol 1999 May;180(5):1104-9

Date

05/18/1999

Pubmed ID

10329862

DOI

10.1016/s0002-9378(99)70601-0

Scopus ID

2-s2.0-0033038831 (requires institutional sign-in at Scopus site)   35 Citations

Abstract

OBJECTIVE: Our aim was to determine the risk of cytologic abnormality on a screening Papanicolaou test for women >/=50 years old with and without a uterine cervix.

STUDY DESIGN: The effect of hysterectomy on abnormal screening Papanicolaou test rates was determined in a cross-sectional analysis of 21,152 women aged >/=50 years who had screening Papanicolaou tests between January and August 1995. We then conducted a nested 1:1 case-control study of 172 case patients and 172 age-matched randomly selected control patients from the cohort. To control for potential confounders, conditional logistic regression was used to assess the effect of hysterectomy status on the risk of an abnormal Papanicolaou test.

RESULTS: Compared with age-matched women with a uterine cervix, those who had a hysterectomy had a 10-fold lower risk of a screening Papanicolaou test abnormality (odds ratio 0.09, 95% confidence interval 0.02-0.24). The risk was further reduced among women taking estrogens (odds ratio 0.02, 95% confidence interval 0.004-0.14) compared with women not using estrogens (odds ratio 0.14, 95% confidence interval 0.04-0.56).

CONCLUSIONS: The reduced risk of Papanicolaou test abnormalities among women aged >/=50 years who have had a hysterectomy should be considered when individual patients are being counseled, screening guidelines are being formulated, and health care resources are being allocated.

Author List

Fox J, Remington P, Layde P, Klein G

MESH terms used to index this publication - Major topics in bold

Aged
Case-Control Studies
Cross-Sectional Studies
Estrogen Replacement Therapy
Female
Humans
Hysterectomy
Logistic Models
Middle Aged
Odds Ratio
Papanicolaou Test
Risk Factors
Uterine Cervical Dysplasia
Uterine Cervical Neoplasms
Vaginal Smears