Doxorubicin cardiomyopathy in children with left-sided Wilms tumor. Med Pediatr Oncol 1982;10(5):483-8
Date
01/01/1982Pubmed ID
6292680Scopus ID
2-s2.0-0020376092 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Two children with Wilms tumor of the left kidney experienced severe anthracycline cardiomyopathy after irradiation to the tumor bed and conventional dosage of doxorubicin. The cardiomyopathy is attributed 1) to the fact that radiation fields for left Wilms tumor include the lower portion of the heart and 2) to the interaction of doxorubicin and irradiation on cardiac muscle. It is recommended that doxorubicin dosage be sharply restricted in children with Wilms tumor of the left kidney who receive postoperative irradiation.
Author List
Pinkel D, Camitta B, Kun L, Howarth C, Tang TMESH terms used to index this publication - Major topics in bold
CardiomyopathiesChild, Preschool
Doxorubicin
Female
Heart
Humans
Kidney Neoplasms
Lung Neoplasms
Nephrectomy
Urography
Wilms Tumor
