BGRT: biologically guided radiation therapy-the future is fast approaching! Med Phys 2007 Oct;34(10):3739-51
Date
11/08/2007Pubmed ID
17985619DOI
10.1118/1.2779861Scopus ID
2-s2.0-34748922860 (requires institutional sign-in at Scopus site) 58 CitationsAbstract
Rapid advances in functional and biological imaging, predictive assays, and our understanding of the molecular and cellular responses underpinning treatment outcomes herald the coming of the long-sought goal of implementing patient-specific biologically guided radiation therapy (BGRT) in the clinic. Biological imaging and predictive assays have the potential to provide patient-specific, three-dimensional information to characterize the radiation response characteristics of tumor and normal structures. Within the next decade, it will be possible to combine such information with advanced delivery technologies to design and deliver biologically conformed, individualized therapies in the clinic. The full implementation of BGRT in the clinic will require new technologies and additional research. However, even the partial implementation of BGRT treatment planning may have the potential to substantially impact clinical outcomes.
Author List
Stewart RD, Li XAMESH terms used to index this publication - Major topics in bold
Cell DeathDNA Damage
Humans
Models, Statistical
Models, Theoretical
Neoplasms
Phantoms, Imaging
Poisson Distribution
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Computer-Assisted
Radiotherapy, Intensity-Modulated
Treatment Outcome
