Faculty Collaboration Database

Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma. Med Phys 2004 Sep;31(9):2449-53

Date

10/19/2004

Pubmed ID

15487724

DOI

10.1118/1.1781332

Scopus ID

2-s2.0-4644341544 (requires institutional sign-in at Scopus site)   79 Citations

Abstract

We have implemented a three-dimensional dose calculation technique accounting for dose inhomogeneity within the liver and tumor of a patient treated with 90Y microspheres. Single-photon emission computed tomography (SPECT) images were used to derive the activity distribution within liver. A Monte Carlo calculation was performed to create a voxel dose kernel for the 90Y source. The activity distribution was convolved with the voxel dose kernel to obtain the three-dimensional (3D) radiation absorbed dose distribution. An automated technique was developed to accurately register the computed tomography (CT) and SPECT scans in order to display the 3D dose distribution on the CT scans. In addition, dose-volume histograms were generated to fully analyze the tumor and liver doses. The calculated dose-volume histogram indicated that although the patient was treated to the nominal whole liver dose of 110 Gy, only 16% of the liver and 83% of the tumor received a dose higher than 110 Gy. The mean tumor and liver doses were 163 and 58 Gy, respectively.

Author List

Sarfaraz M, Kennedy AS, Lodge MA, Li XA, Wu X, Yu CX

MESH terms used to index this publication - Major topics in bold

Body Burden
Brachytherapy
Carcinoma, Hepatocellular
Coated Materials, Biocompatible
Humans
Image Interpretation, Computer-Assisted
Imaging, Three-Dimensional
Injections, Intra-Arterial
Liver
Liver Neoplasms
Microspheres
Organ Specificity
Radiometry
Radiopharmaceuticals
Radiotherapy Dosage
Relative Biological Effectiveness
Tomography, Emission-Computed, Single-Photon
Yttrium Radioisotopes