Association between HLA-D region antigens and disease-free survival in childhood non-T, non-B acute lymphocytic leukemia. Blood 1982 Sep;60(3):698-702
Date
09/01/1982Pubmed ID
6954996Scopus ID
2-s2.0-0019975968 (requires institutional sign-in at Scopus site) 9 CitationsAbstract
The frequency of three serologically defined HLA-D region antigens--DR, MB, and MT--was determined in a group of 74 children with non-T, non-B acute lymphocytic leukemia (ALL). Statistically, there were no significant differences in the frequency of any antigen in these ALL patients as compared with a panel of 85 normal controls. However, significant differences in HLA-DR frequencies were observed between patients who relapsed or who remained disease-free during a 30-mo period of chemotherapy. An increased incidence of relapse was associated with DR5, while disease-free remission during chemotherapy was associated with DR7. Life table analysis also demonstrated that DR5 was significantly associated with a decrease in disease-free survival in these patients. These data suggest that HLA-associated genetic factors may influence the responses of ALL patients to chemotherapy.
Author List
Casper JT, Marrari M, Piaskowski V, Lauer SJ, Duquesnoy RJAuthor
James Casper MD Emeritus Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Child
Child, Preschool
Disease Susceptibility
Female
HLA-DR Antigens
Histocompatibility Antigens Class II
Humans
Infant
Leukemia, Lymphoid
Male
