Hypoventilation in ponies after carotid body denervation. J Appl Physiol 1976 Feb;40(2):184-90
Date
02/01/1976Pubmed ID
2576DOI
10.1152/jappl.1976.40.2.184Scopus ID
2-s2.0-0017260979 (requires institutional sign-in at Scopus site) 52 CitationsAbstract
Seven ponies were subjected to carotid body denervation (CD) and two ponies were sham operated (S). Measurement of arterial blood gases and arterial blood and cerebrospinal fluid (CSF) acid-base balance were made prior to and 1,2,4,9, and 17 wks after surgery in unanesthetized animals. Resting ventilation and ventilatory responsiveness to hypoxia and NaCN infusion were assessed prior to and 2,9, and 17 wks after surgery. Alveolar hypoventilation in the CD ponies was marked 1-2 wk after surgery when VE and VA were reduced 40% and 10%, respectively, from control and PaCO2 was 12-15 mmHg above control. However, the effect was not nearly as great 4, 9, and 17 wk after surgery when the PaCO2 stabilized at approximately 6 mmHg above control PaCO2. Arterial blood pH was normal in the hypercapnic CD ponies, but CSF pH remained acid relative to normal throughout the 17-wk period. Changes in ventilatory responsiveness to hypoxia and NaCN tended to parallel changes in resting ventilation. These findings suggest: 1) the carotid bodies are essential in ponies to maintain normal ventilation: 2) in CD ponies peripheral chemosensitivity is partially regained at some unestablished locus; and 3) pH compensating mechanisms in chronically hypercapnic ponies function relatively better in blood than in CSF.
Author List
Bisgard GE, Forster HV, Orr JA, Buss DD, Rawlings CA, Rasmussen BAuthor
Hubert V. Forster PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acid-Base EquilibriumAnimals
Aorta
Blood Gas Analysis
Carbon Dioxide
Carotid Body
Cyanides
Denervation
Horses
Hydrogen-Ion Concentration
Hypoxia
Lactates
Oxygen
Respiration
