Histopathological features and p53 nuclear protein staining as predictors of survival and tumor recurrence in patients with transitional cell carcinoma of the renal pelvis. J Urol 1995 Oct;154(4):1342-7
Date
10/01/1995Pubmed ID
7544836Scopus ID
2-s2.0-0029118201 (requires institutional sign-in at Scopus site) 32 CitationsAbstract
PURPOSE: We determine which histopathological features are predictive of recurrence and cause-specific survival in renal pelvic transitional cell carcinoma.
MATERIALS AND METHODS: Univariant and multivariant analysis was done on material from 67 patients.
RESULTS: Univariate and multivariate analysis identified lamina propria invasion, grade 3 tumors and capillary-lymphatic invasion as predictors of disease-specific survival. Multicentric disease was the sole independent predictor of recurrence. Multicentric disease and lamina propria invasion were independent predictors of recurrence-free survival. Also, p53 over-expression was not statistically associated with any of the studied prognostic factors.
CONCLUSIONS: Histopathological features remain the cornerstone of prognostic assessment for renal pelvic transitional cell carcinoma.
Author List
Terrell RB, Cheville JC, See WA, Cohen MBAuthor
William See MD Emeritus Professor in the Urology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Carcinoma, Transitional Cell
Female
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms
Kidney Pelvis
Male
Middle Aged
Multivariate Analysis
Neoplasm Recurrence, Local
Predictive Value of Tests
Retrospective Studies
Staining and Labeling
Survival Rate
Tumor Suppressor Protein p53
