Faculty Collaboration Database

Differential effect of ventrolateral medullary cooling on respiratory muscles of goats. J Appl Physiol (1985) 1995 May;78(5):1859-67

Date

05/01/1995

Pubmed ID

7649923

DOI

10.1152/jappl.1995.78.5.1859

Scopus ID

2-s2.0-0029037027 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

The objective was to determine whether there is an inhomogeneous response of respiratory muscles during cooling-induced ventrolateral medullary (VLM) neuronal dysfunction in anesthetized and awake goats. Thermodes for cooling were chronically implanted on all or portions of rostral, intermediate, and caudal areas of the VLM of 16 adult goats. Electromyograms (EMGs) were obtained from chronically implanted wires in the diaphragm (di), transversus abdominis (TA), and triangularis sterni (TS) muscles. During some periods of cooling in 9 of 16 anesthetized airway-intubated goats, complete cessation of EMGdi coincided with a reduced yet sustained inspiratory flow. In six awake tracheotomized goats, VLM cooling decreased (P < 0.05) EMGdi duration and minute activity more than inspiratory duration and minute ventilation. Cooling thus decreased activation of the diaphragm more than activation of other respiratory muscles. On the other hand, during VLM cooling in 3 of 10 airway-intact awake goats, cessation of inspiratory flow coincided with sustained EMGdi, suggesting that cooling decreased stimulation of the upper airway muscles more than stimulation of the diaphragm. Finally, VLM cooling in a majority of goats decreased EMGTA and EMGTS more than EMGdi. We conclude that VLM neuronal dysfunction has a differential effect on respiratory muscles of adult anesthetized and awake goats.

Author List

Forster HV, Lowry TF, Ohtake PJ, Pan LG, Korducki MJ, Forster AL

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anesthesia
Animals
Blood Gas Analysis
Cold Temperature
Diaphragm
Electromyography
Goats
Medulla Oblongata
Respiratory Function Tests
Respiratory Muscles