Expression of CD30 (Ber-H2) in nasopharyngeal carcinoma, undifferentiated type and lymphoepithelioma-like carcinoma. A comparison study with anaplastic large cell lymphoma. Histopathology 2006 Jun;48(7):855-61
Date
05/26/2006Pubmed ID
16722935DOI
10.1111/j.1365-2559.2006.02449.xScopus ID
2-s2.0-33744496007 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
AIMS: Undifferentiated nasopharyngeal non-keratinizing carcinoma (UNPC), formerly known as lymphoepithelioma, frequently metastasizes at an early stage to regional lymph nodes and, thus, may be difficult to distinguish from Hodgkin's lymphoma (HL) or anaplastic large cell lymphoma (ALCL). CD30 expression is a useful diagnostic stain in both HL and ALCL, but its expression in UNPC deserves clarification. The aim of this study was to evaluate CD30 expression in UNPC and lymphoepithelioma-like carcinoma (LELC) from other anatomic locations and compare it with ALCL and squamous cell carcinoma (SCC).
METHODS AND RESULTS: CD30 immunoreactivity was examined in 38 cases of primary or metastatic UNPC, six cases of LELC, 10 cases of SCC and seven cases of ALCL. CD30 immunoreactivity was observed in four of 38 (10.5%) cases of UNPC. CD30 staining was absent in all cases of LELC (0/6) and SCC (0/10). All cases of ALCL (7/7) were strongly positive for CD30.
CONCLUSIONS: The majority of cases of UNPC are immunohistochemically negative for CD30; however, a small subset of cases expresses CD30 antigen. These findings provide additional evidence that CD30 expression is not restricted to neoplasms of lymphoid origin. This should be taken into consideration when interpreting CD30 immunohistology and the possibility of UNPC.
Author List
Kneile JR, Tan G, Suster S, Wakely PE JrMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Carcinoma
Carcinoma, Squamous Cell
Female
Humans
Immunohistochemistry
Ki-1 Antigen
Lymphoma, Large-Cell, Anaplastic
Male
Middle Aged
Nasopharyngeal Neoplasms
