Pyoderma fistulans sinifica (fox den disease): a distinctive soft-tissue infection. Clin Infect Dis 1995 Jul;21(1):162-70
Date
07/01/1995Pubmed ID
7578725DOI
10.1093/clinids/21.1.162Scopus ID
2-s2.0-0029072402 (requires institutional sign-in at Scopus site) 12 CitationsAbstract
Pyoderma fistulans sinifica (PFS, also referred to as fox den disease because its multiple fistulae and sinuses resemble the structure of a fox den) is a distinct chronic infectious disease in which epithelialized tracts form within the subdermal fatty tissue. PFS, which has not been previously described in the English-language literature, must be differentiated from hidradenitis suppurativa, pilonidal sinus, and perianal fistula. The fistulous tracts of PFS are always lined by stratified squamous-cell epithelium but, unlike those of hidradenitis, reach deep into the subcutaneous fat, run epifascially for long distances, and have no relation to skin appendices. We report on 10 men (mean age +/- SD, 36 +/- 5 years) with PFS (mean duration +/- SD, 11 +/- 7 years). Bacterial cultures of affected tissue from these patients yielded a total of 14 facultative and 31 obligate anaerobic species. Treatment consisted of wide en-bloc excision down to the fascia, including all fistulae. Antibiotic therapy temporarily reduced purulent discharge but did not eradicate the infection. Two patients who underwent fistulotomy without wide en-bloc excision developed recurrences.
Author List
Wittmann DH, Schein M, Seoane D, Aprahamian C, Komorowski RA, Georgakas K, Quebbeman EJ, Wallace JR, Condon REMESH terms used to index this publication - Major topics in bold
AbscessAdult
Bacteria, Anaerobic
Bacterial Infections
Cutaneous Fistula
Hidradenitis Suppurativa
Humans
Male
Middle Aged
Pyoderma
Recurrence
Reoperation
Skin
Soft Tissue Infections
